DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42534 and Nfkb2

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_001170841.1	Gene:	Nfkb2 / 18034	MGIID:	1099800	Length:	900	Species:	Mus musculus

Alignment Length:	438	Identity:	105/438 - (23%)
Similarity:	154/438 - (35%)	Gaps:	114/438 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 MPGSSQDTDAAAEAAVDVPETDPDPAQLTVSQSQSSSTVARRRLAEGCTSLMYACQRGDIVQVLA 141
            |.||.:||||...|  :.|.|.|:..|   .:.|:..|:.|.|
Mouse   407 MAGSRRDTDAGEGA--EEPRTPPEAPQ---GEPQALDTLQRAR---------------------- 444

  Fly   142 QMREKPELLRQRDRSHRNALHYCAAQDSEGSKDLVAAASIAIAAPELLESADEDGFTPLHLAVIQ 206
              .....|.....||.|..|.|....|         |.::......||.:.||:|.||||||:|.
Mouse   445 --EYNARLFGLAQRSARALLDYGVTAD---------ARALLAGQRHLLMAQDENGDTPLHLAIIH 498

  Fly   207 GNLAMVNLLL-----ANKADVNAVDNEGHSV-VHWATVCGEVESLRAVLAAGASVAKPDANGGTP 265
            |...::..:.     |....|..:.|..|.. :|.|.:.|:...:..:|..||.....|.:|.:.
Mouse   499 GQTGVIEQIAHVIYHAQYLGVINLTNHLHQTPLHLAVITGQTRVVSFLLQVGADPTLLDRHGDSA 563

  Fly   266 LHYAAQMCGASKQDSKQQASSSNSSRLSLEILGILLSHPQSSVDVQDKDGRQPLLWAASAGSAKA 330
            ||.|.:                                                   |.|.:.:.
Mouse   564 LHLALR---------------------------------------------------AGAAAPEL 577

  Fly   331 VIALVKAGAR-----VESSDKDGLTALHCAGSRGHTECIDTLIGLCGAPTDLID-SNGCTALHYA 389
            :.||:::||.     :...|.:||..:|.|......||:|.|:. |||..:..: ..|.||||.|
Mouse   578 LQALLRSGAHAVPQILHMPDFEGLYPVHLAVHARSPECLDLLVD-CGAEVEAPERQGGRTALHLA 641

  Fly   390 VTLGHADATARLL-DLEADPNRQDRKGRTPAHCGCSKGQFETLKLLKERGANLWLRNAKGDLPLH 453
            ..:........|: .|.|:.|.:...|.||.|.....|.....:||.:.||::...|.:...||.
Mouse   642 TEMEELGLVTHLVTKLHANVNARTFAGNTPLHLAAGLGSPTLTRLLLKAGADIHAENEEPLCPLP 706

  Fly   454 EAAASGRRELLEWLLAQRPKQVN---------TTSNDGRSLLHIAAAN 492
            ..:.||.....|.  .:|..|.|         |.|...::||..||.|
Mouse   707 SPSTSGSDSDSEG--PERDTQRNFRGHTPLDLTCSTKVKTLLLNAAQN 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	23/103 (22%)
		ANK	193..335	CDD:238125	29/147 (20%)
		ANK repeat	195..226	CDD:293786	11/35 (31%)
		Ank_5	214..269	CDD:290568	14/60 (23%)
		ANK repeat	228..259	CDD:293786	7/31 (23%)
		ANK repeat	314..345	CDD:293786	6/35 (17%)
		Ank_2	319..412	CDD:289560	28/99 (28%)
		ANK	345..468	CDD:238125	37/124 (30%)
		ANK repeat	347..379	CDD:293786	11/31 (35%)
		ANK repeat	381..412	CDD:293786	10/31 (32%)
		ANK	409..538	CDD:238125	26/93 (28%)
		ANK repeat	414..479	CDD:293786	19/73 (26%)
		ANK repeat	419..445	CDD:293786	6/25 (24%)
		Ank_2	420..511	CDD:289560	22/82 (27%)
		ANK repeat	481..511	CDD:293786	5/12 (42%)
		Ank_2	486..>545	CDD:289560	4/7 (57%)
		ANK repeat	516..542	CDD:293786
Nfkb2	NP_001170841.1	RHD-n_NFkB2	38..221	CDD:143650
		IPT_NFkappaB	228..327	CDD:238582
		Nuclear localization signal. /evidence=ECO:0000255	337..341
		GRR	346..377
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	403..434		12/31 (39%)
		PHA03095	459..>705	CDD:222980	71/306 (23%)
		ANK repeat	487..524	CDD:293786	11/36 (31%)
		ANK 1	487..516		10/28 (36%)
		ANK repeat	526..557	CDD:293786	7/30 (23%)
		ANK 2	526..555		7/28 (25%)
		ANK 3	559..590		10/81 (12%)
		ANK repeat	559..586	CDD:293786	8/77 (10%)
		ANK repeat	599..630	CDD:293786	11/31 (35%)
		ANK 4	599..628		11/29 (38%)
		ANK repeat	633..665	CDD:293786	10/31 (32%)
		ANK 5	633..663		9/29 (31%)
		ANK repeat	667..698	CDD:293786	9/30 (30%)
		ANK 6	667..696		9/28 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	698..734		9/37 (24%)
		ANK 7	729..755		7/24 (29%)
		Death_NFkB2_p100	774..849	CDD:176776
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000