DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42534 and Nfkb1

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_032715.2	Gene:	Nfkb1 / 18033	MGIID:	97312	Length:	971	Species:	Mus musculus

Alignment Length:	610	Identity:	129/610 - (21%)
Similarity:	193/610 - (31%)	Gaps:	224/610 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 PAQLTVSQSQSSSTVARRRLAEGCTSLMYACQRGDIVQVLAQMREKPELLRQRD----------- 154
            |.....|..:.|.|:..:.......||..||.:.:.:.:.:.|.:|.:.:..:|
Mouse   441 PKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALASTMEDKEQDMGFQDNLFLEKALQLA 505

  Fly   155 RSHRNAL-----------------HYCAAQDSEGS---------------KDLVAAASIAIAAPE 187
            |.|.|||                 |..|.||..|.               :||:...| .:.:.:
Mouse   506 RRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTS-GLISDD 569

  Fly   188 LLESADEDGFTPLHLAVIQGNLAMVNLLLANKADVNAVDNEGHSVVHWATVCGEVESLRAVLAAG 252
            ::...::...||||||||.....:|..||...||::.:|..|:||:|.|...|....|..:|
Mouse   570 IINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAKEGHDRILSILL--- 631

  Fly   253 ASVAKPDANGGTPLHYAAQMCGASKQDSKQQASSSNSSRLSLEILGILLSHPQSSVDVQDKDGRQ 317
                                      .|::.|.              |:.||..       :|..
Mouse   632 --------------------------KSRKAAP--------------LIDHPNG-------EGLN 649

  Fly   318 PLLWAASAGSAKAVIALVKAGARVESSD-KDGLTALHCAGSRGHTECIDTLIGLCGAPTDLIDSN 381
            .:..|..:.|...::.||.|||.|.:.: |.|.||||.|                 ...|.|...
Mouse   650 AIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSGRTALHLA-----------------VEYDNISLA 697

  Fly   382 GCTALHYAVTLGHADATARLLDLEADPNRQDRKGRTPAHCGCSKGQFETLKLLKERGANLWLRN- 445
            ||..|...   .|.|:|.             ..|.||.|....:|......|||..||:..:.|
Mouse   698 GCLLLEGD---AHVDSTT-------------YDGTTPLHIAAGRGSTRLAALLKAAGADPLVENF 746

  Fly   446 -------------------AKGDLPLHEAAASGRRELLEW----LLAQRPKQVNTTSNDGRSLLH 487
                               ..|..||..||        .|    :|..:|.:...||:|   :|.
Mouse   747 EPLYDLDDSWEKAGEDEGVVPGTTPLDMAA--------NWQVFDILNGKPYEPVFTSDD---ILP 800

  Fly   488 IAAANDYTD-----MCKLL---------------LDYGADVNAV-------------YRNSRGLV 519
            .......|:     :||||               |..|...||.             |..|.|.:
Mouse   801 QGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTI 865

  Fly   520 LTPLDGALQRGHRSTAKFLQANGGQPANKVRLSSRRTGNPFHETNATDMVRPLKYVEKEELHDL- 583
            ...::...|.|:....:.:||                   ...|.||....|   |...::|.|
Mouse   866 KELMEALQQMGYTEAIEVIQA-------------------AFRTPATTASSP---VTTAQVHCLP 908

  Fly   584 ---RSSKKYVVYLKRSDS--DNGNE 603
               .|:::::..|:.|||  |:|.|
Mouse   909 LSSSSTRQHIDELRDSDSVCDSGVE 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	32/141 (23%)
		ANK	193..335	CDD:238125	30/141 (21%)
		ANK repeat	195..226	CDD:293786	13/30 (43%)
		Ank_5	214..269	CDD:290568	13/54 (24%)
		ANK repeat	228..259	CDD:293786	8/30 (27%)
		ANK repeat	314..345	CDD:293786	9/30 (30%)
		Ank_2	319..412	CDD:289560	23/93 (25%)
		ANK	345..468	CDD:238125	32/147 (22%)
		ANK repeat	347..379	CDD:293786	7/31 (23%)
		ANK repeat	381..412	CDD:293786	6/30 (20%)
		ANK	409..538	CDD:238125	37/185 (20%)
		ANK repeat	414..479	CDD:293786	19/88 (22%)
		ANK repeat	419..445	CDD:293786	7/25 (28%)
		Ank_2	420..511	CDD:289560	28/134 (21%)
		ANK repeat	481..511	CDD:293786	10/49 (20%)
		Ank_2	486..>545	CDD:289560	17/91 (19%)
		ANK repeat	516..542	CDD:293786	5/25 (20%)
Nfkb1	NP_032715.2	RHD-n_NFkB1	40..241	CDD:143651
		IPT_NFkappaB	248..349	CDD:238582
		Nuclear localization signal. /evidence=ECO:0000255	358..363
		GRR	370..392
		Interaction with CFLAR. /evidence=ECO:0000250	433..971		129/610 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..470		6/28 (21%)
		ANK repeat	538..575	CDD:293786	4/37 (11%)
		Ank_4	539..598	CDD:290365	13/59 (22%)
		ANK	572..701	CDD:238125	47/195 (24%)
		ANK repeat	577..608	CDD:293786	13/30 (43%)
		Ank_2	582..676	CDD:289560	34/143 (24%)
		Essential for interaction with HIF1AN. /evidence=ECO:0000250	646..680		9/33 (27%)
		ANK repeat	646..677	CDD:293786	9/30 (30%)
		Ank_5	666..722	CDD:290568	25/88 (28%)
		ANK repeat	680..712	CDD:293786	13/51 (25%)
		Death_NFkB1_p105	812..886	CDD:260063	13/73 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000