DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42534 and mlt-4

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_507912.2	Gene:	mlt-4 / 180329	WormBaseID:	WBGene00013835	Length:	624	Species:	Caenorhabditis elegans

Alignment Length:	483	Identity:	136/483 - (28%)
Similarity:	197/483 - (40%)	Gaps:	113/483 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 AEGCTSLMYACQRGD--IVQVLAQMREKPELLR----QRDRSHRNALHYCAAQ------------ 167
            :|..|.|..|..:.|  |:::..::.:.|:::.    .:|:..|:.|||.|.:
Worm   129 SESVTPLHIAATKQDTKILKIFVEILKTPKVMELFSIVKDKRDRSPLHYAACKVNLEALRILLFV 193

  Fly   168 DSEGSKD---------------LVAAASI----AIAAPELLES--------ADEDGFTPLHLAVI 205
            |..|..|               |:.|..:    ||.....||.        .:.||.|.||:||.
Worm   194 DPNGGPDFGFTVDQRDKFGIIPLMCAVGVNLPQAIPVIRFLEKKKPVSKTRQNRDGMTALHIAVA 258

  Fly   206 QGNLAMVNLLLANKADVNAVDNEGHSVVHWATVCGEVESLRAVLAAGASVAKPDANGGTPLHYAA 270
            ..||..|.||:...:.|:.||||..:.:|:|...|..|.::.:|..||..:..|..|.||.||||
Worm   259 ARNLEAVQLLIELGSSVDLVDNEQRTPLHYAAEQGYPEIVKFLLCNGARNSTRDHIGATPAHYAA 323

  Fly   271 QMCGASKQDSKQQASSSNSSRLSLEILGILLSHPQSSVDVQDKDGRQPLLWAASAGSAKAVIALV 335
            |                    .|:|.|.||.:..:.: :|.|.:||..|:||..||:.:.:..|:
Worm   324 Q--------------------FSVECLKILFAESKIT-EVNDNEGRSCLMWAVCAGNIEVINYLI 367

  Fly   336 KA--GARVESSDKDGLTALHCAGSRGHTECIDTLIGLCGAPTDLIDSNGCTALHYAVTLGHADAT 398
            :.  ..:..:.||:|.||||.|...|| |.:..::...|......|::..||||.|...||.|..
Worm   368 QREDAPKRAACDKNGYTALHLAAMVGH-EKVCKILTNQGWSLSERDNHSNTALHLASGRGHTDVL 431

  Fly   399 ARLLDLEADPNRQDRKGRTPAHCGCSKGQFETLK-LLKERGANLWLRNA----------KGDLPL 452
            ..|:...|:.|..|..|||.....|..||..||. ::||.|.. |..:.          .|...|
Worm   432 RCLVASGANMNDVDEVGRTAVFWACMGGQAHTLHCMIKELGFE-WRTSGSVNTRPKCDKNGRTAL 495

  Fly   453 HEAAA----------SGRRE-------LLEWLLAQRPKQVNTTSNDGRSLLHIAAANDYTDMCKL 500
            |.||.          |..:|       |:.||           ..:|.:.||.|......|....
Worm   496 HAAAVESSACINVLLSIEKEDNFLSSPLVGWL-----------DKNGETALHEACLASRIDCILS 549

  Fly   501 LLDYGADVNAVYRNSRGLVLTPLDGALQ 528
            ||:.|:.|||..|..|    ||||.|:|
Worm   550 LLNGGSAVNAFGRPQR----TPLDCAMQ 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	33/143 (23%)
		ANK	193..335	CDD:238125	47/141 (33%)
		ANK repeat	195..226	CDD:293786	13/30 (43%)
		Ank_5	214..269	CDD:290568	19/54 (35%)
		ANK repeat	228..259	CDD:293786	8/30 (27%)
		ANK repeat	314..345	CDD:293786	8/32 (25%)
		Ank_2	319..412	CDD:289560	30/94 (32%)
		ANK	345..468	CDD:238125	46/150 (31%)
		ANK repeat	347..379	CDD:293786	10/31 (32%)
		ANK repeat	381..412	CDD:293786	11/30 (37%)
		ANK	409..538	CDD:238125	43/148 (29%)
		ANK repeat	414..479	CDD:293786	22/92 (24%)
		ANK repeat	419..445	CDD:293786	9/26 (35%)
		Ank_2	420..511	CDD:289560	29/118 (25%)
		ANK repeat	481..511	CDD:293786	10/29 (34%)
		Ank_2	486..>545	CDD:289560	18/43 (42%)
		ANK repeat	516..542	CDD:293786	7/13 (54%)
mlt-4	NP_507912.2	Ank_2	52..152	CDD:393464	6/22 (27%)
		ANK repeat	88..128	CDD:293786
		ANKYR	115..314	CDD:223738	47/184 (26%)
		ANK repeat	133..168	CDD:293786	6/34 (18%)
		ANK repeat	170..246	CDD:293786	14/75 (19%)
		PHA03095	201..>452	CDD:222980	82/272 (30%)
		ANK repeat	248..279	CDD:293786	13/30 (43%)
		ANK repeat	281..312	CDD:293786	8/30 (27%)
		ANK repeat	346..379	CDD:293786	8/32 (25%)
		ANKYR	358..559	CDD:223738	58/213 (27%)
		ANK repeat	381..412	CDD:293786	10/31 (32%)
		ANK repeat	414..445	CDD:293786	11/30 (37%)
		ANK repeat	490..528	CDD:293786	10/48 (21%)
		ANK repeat	530..561	CDD:293786	11/30 (37%)
		ANK repeat	563..597	CDD:293786	7/15 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000