DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42534 and nphp-2

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_001300226.1	Gene:	nphp-2 / 178671	WormBaseID:	WBGene00021304	Length:	834	Species:	Caenorhabditis elegans

Alignment Length:	791	Identity:	207/791 - (26%)
Similarity:	342/791 - (43%)	Gaps:	119/791 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 IVQVLAQMREKPELLRQRDRSHRNALHYCAAQDSEGSKDLVAAASIAIAAPELLESADEDGFTPL 200
            ::|.:  :.|.||...|.:...:.|:||.||     |.||.....:.:|...||:..|..|.|||
Worm    17 VIQKI--LEEHPEEASQPNEEKKVAIHYAAA-----SGDLKTLKLVFLADRSLLDVKDATGQTPL 74

  Fly   201 HLAVIQGNLAMVNLLLANKADVNAVDNEGHSVVHWATVCGEVESLRAVLAAGASV-AKPDANGGT 264
            ..|::.|.:...:.|....||....|.:|.:.:|||.|||:::||...:.....| ||......|
Worm    75 LCALMAGKIENADFLANTGADAECHDEQGRNALHWAVVCGQLDSLNWAINKNVEVNAKDQYQRCT 139

  Fly   265 PLHYAAQMCGASKQDSKQQASSSNSSRLSLEILGILLSHPQSSVDVQDKDGRQPLLWAASAGSAK 329
            |||||.             .|...:..:|..||..||.| .:..:..|.|.|.|:.|.:|.|:.:
Worm   140 PLHYAT-------------CSEDIAPEVSQAILITLLKH-GADPNAIDADDRTPIHWCSSNGNLE 190

  Fly   330 AVIALVKAGARVESSDKDGLTALHCAGSRGHTECIDTLIGLCGAP-TDLIDSNGCTALHYAVTLG 393
            |:.||..:|..:...||:.||.||||.|.|:.|.|:..:.....| .|.||..|.|||.||::.|
Worm   191 AIKALYNSGGDLLCRDKEHLTILHCAASHGYHEVIEFALKHVNKPFIDEIDRAGHTALFYAISFG 255

  Fly   394 HADATARLLDLEADPNRQDRKGRTPAHCGCSKGQFETLKLLKERGANLWLRNAKGDLPLHEAAAS 458
            |.::..:||...|:||.||::..|.||...||||...|||||:..|:..::|.:||||.|||..:
Worm   256 HYESALKLLQNNANPNHQDQRLATAAHSAASKGQMRMLKLLKQFNASFDIQNYRGDLPFHEAVQA 320

  Fly   459 GRRELLEWLLAQRPKQVNTTSNDGRSLLHIAAANDYTDMCKLLLDYGADVNAVYRNSRGLVLTPL 523
            |.::::|||||.....::..:::||:.:|:||:....:|..||......|:.:....:. :.|||
Worm   321 GSKDVVEWLLAVDESVLDIPNHNGRTAIHLAASVGNLEMVILLCTKKCFVDPLCSREKE-IFTPL 384

  Fly   524 DGALQRGHRSTAKFLQANGGQPANKVRLSSRRTGNPFHETNATDMVRPLKYVEKEELHDLRSSKK 588
            |.|.::.|....::|          .:|...::...|                         |.:
Worm   385 DLATKQNHVVVVEYL----------TKLCRAKSSKEF-------------------------SPE 414

  Fly   589 YVVYLKRSDSDNGNENGKADVGDGDCSCSEQTYRKEQRLRHVCRRHKRRQLRRRTSSCGESKHER 653
            |:        :|...|.:|.|.:.            :|.|:..:..:::| ||.::|.|..:.||
Worm   415 YI--------ENWKTNFEAMVAEA------------RRKRNELKAEQKKQ-RRPSTSDGIVETER 458

  Fly   654 CSEICRSKSNIEIRRRKSRERYASSSEWEEE-SAEDSCENCCYHKRQ----KDRVVNRKRSTSSR 713
            ..||.....|...|..||.:..|...::.:. |..:..|.....|::    |:.:.|.::.....
Worm   459 KKEIADVGVNTSQRSIKSADSNAPKRKYSKSTSVTNLTEIPSIPKKELEALKESIENGQKFVDDD 523

  Fly   714 KSKNRDSSDPDEKNHSENHSSPEKGSRKPLAVNGDHQADNGKDQ--------TSTKERPPSASRH 770
            ...:.|..|.|::  .||.......|....:.:.|.:.|...|:        ..||...|.|:..
Worm   524 AEDHLDILDVDDE--FENLPPISDLSESSTSTDNDSEEDKSDDEDVERKVTVQETKATVPLAAAK 586

  Fly   771 QTPPTKEGTFIKSPTQSAKSEKSGQMDNLLVEESHAVELTDEEQEAAKSVVTQVDVHHDAEEIQT 835
            :   |::...|:|.:...|...|....|:::......|:..:..:        ||::.|.:
Worm   587 K---TRKEVRIESGSNKKKKSASKSRGNVVMRVRREPEVGSDTGD--------VDIYDDGD---- 636

  Fly   836 SKSSEEAPQAEENGKEKESEQEVKLQLSE-----EETQLVSKEVEQ-VIIIA---ATALSSESKS 891
            .:.|::..:.:.|.||..|....:..:.|     |.|.|...:::. .::||   |.||......
Worm   637 GRPSDDEEEKKPNDKETASTPTNRRYIHERAIFQELTHLKRMQIQYGKVLIARKNARALFRNYYH 701

  Fly   892 SSEEKSVEKEL 902
            ...|:..||.|
Worm   702 PGTEQVQEKVL 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	26/89 (29%)
		ANK	193..335	CDD:238125	45/142 (32%)
		ANK repeat	195..226	CDD:293786	9/30 (30%)
		Ank_5	214..269	CDD:290568	20/55 (36%)
		ANK repeat	228..259	CDD:293786	12/31 (39%)
		ANK repeat	314..345	CDD:293786	10/30 (33%)
		Ank_2	319..412	CDD:289560	36/93 (39%)
		ANK	345..468	CDD:238125	55/123 (45%)
		ANK repeat	347..379	CDD:293786	12/32 (38%)
		ANK repeat	381..412	CDD:293786	13/30 (43%)
		ANK	409..538	CDD:238125	45/128 (35%)
		ANK repeat	414..479	CDD:293786	27/64 (42%)
		ANK repeat	419..445	CDD:293786	12/25 (48%)
		Ank_2	420..511	CDD:289560	34/90 (38%)
		ANK repeat	481..511	CDD:293786	9/29 (31%)
		Ank_2	486..>545	CDD:289560	14/58 (24%)
		ANK repeat	516..542	CDD:293786	7/25 (28%)
nphp-2	NP_001300226.1	ANK repeat	39..67	CDD:293786	11/32 (34%)
		PHA02874	46..>361	CDD:165205	117/328 (36%)
		ANK repeat	69..100	CDD:293786	9/30 (30%)
		ANK repeat	103..133	CDD:293786	11/29 (38%)
		ANK repeat	135..173	CDD:293786	13/51 (25%)
		ANK repeat	175..206	CDD:293786	10/30 (33%)
		Ank_2	180..274	CDD:372319	36/93 (39%)
		ANK repeat	208..241	CDD:293786	12/32 (38%)
		ANK repeat	243..274	CDD:293786	13/30 (43%)
		ANK repeat	276..307	CDD:293786	13/30 (43%)
		ANK repeat	343..377	CDD:293786	9/33 (27%)
		PTZ00108	<414..650	CDD:240271	50/273 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BHF1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto19070
orthoMCL	1	0.900	-	-		OOG6_114780
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17007
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.700