DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42534 and mib-1

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_499452.2	Gene:	mib-1 / 176558	WormBaseID:	WBGene00012933	Length:	765	Species:	Caenorhabditis elegans

Alignment Length:	688	Identity:	151/688 - (21%)
Similarity:	246/688 - (35%)	Gaps:	164/688 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 VQVLAQMREKPELLRQRDRSHRNALHYCAAQD-SEGSKDLVA-------AASIAIAAPELLESAD 193
            |:|...:.:.|||.:.......:||.:....| |:|  ||||       ..:|.|.|.:
Worm    71 VRVYYAVPQNPELFKLSTEWPLDALEFPQCIDHSKG--DLVAITRGDPEKTTIGIVATK------ 127

  Fly   194 EDGFTPLHLAVIQGNLAMV----NLLLANKADVNAVDNEGHSVVHWATVCGEVESLRAVLAAGAS 254
                .||:|..|..:|..:    |..:..:..|....|.|     |.....::...........|
Worm   128 ----EPLNLGGIPKHLVQLKSASNPTITREIQVAVNANTG-----WTDERRDIFLCPVYSGPRLS 183

  Fly   255 VAKPDANGGTPLHYAAQMCGASKQDSKQQASSSNSSRLSLEIL-GILLSHPQSSVDVQDKDGRQP 318
            :...|.|..:...|...:.|.:.....|..::.....||..:| ..:.|.||....:  .||:.|
Worm   184 MIARDNNEPSVHTYKHTIHGYTPDTLMQVIANWGEDALSYALLVESIRSDPQQVRTL--FDGQLP 246

  Fly   319 LLWAASAGSAKAVIALVKAGARVESSDKDGLTALHCAGSRGHTECIDTLIGLCGAPTDLID--SN 381
            |..|.:......|:.||..||...:.|.:..|.:|.|..||..:.:||::.|  .|.|:..  :|
Worm   247 LFRAVADDLRNVVVMLVALGADRTARDSENRTIIHVAAERGLDKMLDTVMLL--LPKDINSQAAN 309

  Fly   382 GCTALHYAVTLGHADATARLLD----LEADPNRQDRKGRTPAHCGC-----SKGQFETLKLLKER 437
            |.|.||.|....||....|||.    :...||   ..|.|..|..|     |..:....::|...
Worm   310 GLTPLHLAARHAHAACIDRLLGTSTCIPCVPN---NFGDTLLHEVCRLPESSNKKAAISRILTNT 371

  Fly   438 GANLWLRNAKGDLPLHEAAASGRRELLEWLLAQRPKQVNTTSNDGRSLLHIAAANDYTDMCKLLL 502
            .||:...|.....|:..|..||....:|.||..|....||||..|.|.||.|||:.:.::...|:
Worm   372 RANIHHVNNSNMTPIQIAIMSGHVSTVEQLLLLRASYRNTTSKTGMSALHFAAASGHANVVNKLI 436

  Fly   503 DYGADVNAVYRNSRGLVLTPLD---GALQRG-HRSTAKFLQANGGQPANKVRLSSRRTGNPFHET 563
            ..|.:|:...:..||::...|:   |..::. :|..|.......|.|:|.:.|:.        :|
Worm   437 SLGLEVHRRDKFGRGVLHYALEKWTGEAEKDCNRLAAIQALVKAGAPSNIIDLNG--------QT 493

  Fly   564 NATDMVRPLKYVEKEELHDLRSSKKY---------------------------------VVYLKR 595
            ....::|.:          |.:|::|                                 :.:|..
Worm   494 PVFQLIREM----------LSNSEQYPASLVPVCAQLVRTNLNLDEMASRLRPMWQLATICFLVA 548

  Fly   596 SDSD-NGNENGKADVGDGDCSCSEQTYRKEQRLRHVCRRHKRRQLRRRTSSCGESKHER------ 653
            :.:| |..:.....|.|   .|.|.::|  ..:.|:.:. |:||:.....:..|.|.:.
Worm   549 NGADLNVKDRRGMTVMD---LCEESSFR--SIIVHIAQT-KQRQVMPMMMAMSEDKFDSTEVTMC 607

  Fly   654 ------------------------CSE--------ICRSKSN---------IEIRRR----KSRE 673
                                    |:|        :||...|         ::|..|    ...:
Worm   608 TFSCLNSVATVKLDPCGHRVACVDCTEKVAIRRCPVCRQFINEAHDQDGKPVQIGSRCHEPSDGD 672

  Fly   674 RYASSSEWEEESAEDSCENCCYH-KRQKDRVVN--RKR 708
            |...|:|..::.|:|:....... :|:|...:|  |||
Worm   673 RQQVSAEVRKQIADDAAREAKIEVEREKQNELNQLRKR 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	24/100 (24%)
		ANK	193..335	CDD:238125	28/146 (19%)
		ANK repeat	195..226	CDD:293786	7/34 (21%)
		Ank_5	214..269	CDD:290568	7/54 (13%)
		ANK repeat	228..259	CDD:293786	3/30 (10%)
		ANK repeat	314..345	CDD:293786	10/30 (33%)
		Ank_2	319..412	CDD:289560	31/98 (32%)
		ANK	345..468	CDD:238125	38/133 (29%)
		ANK repeat	347..379	CDD:293786	10/31 (32%)
		ANK repeat	381..412	CDD:293786	13/34 (38%)
		ANK	409..538	CDD:238125	38/137 (28%)
		ANK repeat	414..479	CDD:293786	19/69 (28%)
		ANK repeat	419..445	CDD:293786	6/30 (20%)
		Ank_2	420..511	CDD:289560	29/95 (31%)
		ANK repeat	481..511	CDD:293786	10/29 (34%)
		Ank_2	486..>545	CDD:289560	15/62 (24%)
		ANK repeat	516..542	CDD:293786	6/29 (21%)
mib-1	NP_499452.2	ANK repeat	242..273	CDD:293786	10/30 (33%)
		Ank_2	247..>313	CDD:289560	20/67 (30%)
		ANK repeat	275..307	CDD:293786	10/33 (30%)
		ANK	341..459	CDD:238125	35/120 (29%)
		ANK repeat	343..379	CDD:293786	8/35 (23%)
		Ank_4	344..402	CDD:290365	14/57 (25%)
		Ank_4	382..436	CDD:290365	19/53 (36%)
		ANK repeat	384..413	CDD:293786	10/28 (36%)
		ANK	410..579	CDD:238125	37/191 (19%)
		ANK repeat	415..446	CDD:293786	10/30 (33%)
		Ank_2	420..>494	CDD:289560	18/81 (22%)
		ANK repeat	448..488	CDD:293786	9/39 (23%)
		ANK repeat	490..557	CDD:293786	8/84 (10%)
		zf-C3HC4_3	611..650	CDD:290631	4/38 (11%)
		zf-C3HC4_3	717..760	CDD:290631
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000