DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42534 and AgaP_AGAP011932

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	XP_320601.4	Gene:	AgaP_AGAP011932 / 1280737	VectorBaseID:	AGAP011932	Length:	1186	Species:	Anopheles gambiae

Alignment Length:	895	Identity:	197/895 - (22%)
Similarity:	315/895 - (35%)	Gaps:	226/895 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 EAADKVIAMPGSSQDT-DAAAEAAVDVPE---TDPDPAQLTVSQSQSSSTVARRRLAEGCTSL-- 127
            |..|.|:|.|.|.:.| :......|..|.   .|..|.|..|..           ..:.|:.|
Mosquito   313 EDHDIVVAYPSSHRWTFNPTVLTIVSSPMMLLADNQPQQFAVGD-----------FVKICSDLER 366

  Fly   128 MYACQRGD------IVQVLAQMREKPELLRQRDRSHRNALHYC-------------AAQDSEGSK 173
            :...|||.      :|..|.::....::....|..    :..|             .|..|:|:.
Mosquito   367 IKILQRGHGEWAEAMVPTLGKVGRVQQVYHDNDLK----VEVCNTSWTYNPLAVTKVASSSDGAT 427

  Fly   174 DLVA-AASIAIAAPELLE-SADEDGFTPLHLAVIQGNLAMVNLLLANKADVNAVDNEGHSVVHWA 236
            .:.. ...::....:|.| .|..|....|..|...|:.|.|...|...|....|.....|....|
Mosquito   428 AVTTNGERLSAILKKLFEPHASGDTTEELVKAAANGDKAKVEEFLIGSAGGQNVAPSSSSAAGAA 492

  Fly   237 TVCGEVESLRAVLAAGASVAKPDANGGTPLHYAAQMCGASKQDSKQQASSSNSSRLSLEILGILL 301
            ...||.:          ||.|.|.||....|.|.            ||:|.|.   .||::.:||
Mosquito   493 ASLGESQ----------SVVKVDVNGVFAGHTAL------------QAASQNG---HLEVIEVLL 532

  Fly   302 SHPQSSVDVQDKDGRQPLLWAASAGSAKAVIALVKAGARVESSDKDGLTALHCAGSRGHTECIDT 366
            .| .:.|:::||||.:.:..||.......:..|.||||.:.:.:|...||||.|.::||...:.|
Mosquito   533 RH-NADVEIEDKDGDRAVHHAAFGDEPGVMGMLAKAGADLNARNKRRQTALHIAVNKGHFNVVKT 596

  Fly   367 LIGLCGAPTDLIDSNGCTALHYAVTLGHADATARLLDLEADPNRQDRKGRTPAHCGCSKGQFETL 431
            |:.|...|: |.||.|.||||.|::..|.:..|.|||..||....:..|....|....||....:
Mosquito   597 LLELNCHPS-LQDSEGDTALHDAISKEHDNMLALLLDNGADITLTNNNGFNALHHAALKGNPSAM 660

  Fly   432 KLLKERGANLWLRNAKGD---LPLHEAAASGRRELLEWLLAQRPKQVNTTSNDGRSLLHIAAAND 493
            |:|..:...||:...|.|   ..||.||.:...|:.|.|:......::..:.:.::.||:|....
Mosquito   661 KVLLTKTNRLWIVEEKKDDGYTALHLAALNNHVEIAELLVRMGKANMDCQNVNLQTALHLAVERQ 725

  Fly   494 YTDMCKLLLDYGADVNAVYRNSRGLVLTPLDGAL-----------------------------QR 529
            :..:.|||:..||::|...::..    |||..||                             ::
Mosquito   726 HVQIVKLLVREGANLNIPDKDGD----TPLHEALRHHTLSQLRQLQDVEGFGKILMGLRNNTDKK 786

  Fly   530 GHRSTAKFLQANGGQPANKVRLSSRRTGNP----------------FHETNATDM---------- 568
            ...|.|.||.|||..    :.:.:|:...|                ::|....||
Mosquito   787 ASASIACFLAANGAD----LTIKNRKLQTPLDLCPDPNLCKTLIKCYNERKTEDMDSMTLGMASH 847

  Fly   569 -------VRPLK---YVEKEE-------------------LHDLRSSKKYVVYLKRSDSDNGNEN 604
                   ..||:   |...:|                   |:..:.....::.|.:. |...|..
Mosquito   848 TGGGGGPTMPLRRGGYRPPDEPIASTSAGNPGTSGLGSGGLNHAQIDANLLMGLSKM-SIQPNAA 911

  Fly   605 GKADVGDG------DC-SCSEQTYRKEQRLRHVCRRHKRRQLRRRT--SSCGESKHERCSEIC-- 658
            |:|:....      :| .||:|                    :|.|  ..||   |..|.|.|
Mosquito   912 GEANTNPAVSGPLDECLLCSDQ--------------------KRDTVFKPCG---HVVCCENCGP 953

  Fly   659 RSKSNIEIRRR-KSRERYASSSEWEEESAE---------DSCENC------CYHKR-QKDRVVNR 706
            |.|..:..|.. .|||:........:..|.         .:||:|      |...| |.:::|..
Mosquito   954 RIKKCLICRESVLSREKIDECLVCSDRKASVFFKPCGHMVACEHCAPIMKKCVQCRTQLEQMVPL 1018

  Fly   707 KRSTSSRKS--KNRDSSDPDEKNHSENHSSPEKGSRKPLAVNGDHQADNGKDQTSTKERPPSASR 769
            ...:..:.|  ..:...:..:|:...||::.::..::.|  .|.::|..|....:|..  |:||.
Mosquito  1019 SVCSGGQGSVINIQHPVEDGKKDLLHNHNASQQQQQQLL--QGTNKAGLGVAMNNTMS--PNASA 1079

  Fly   770 HQTPPTKEGTFIKSPTQ----SAKSEKSGQMDNLLVEESHAVELTDEEQE 815
            ........|..:.:..|    ::.|..|...:..|:...:.:.|.|:.|:
Mosquito  1080 LAAGSGSGGVALGNNGQAVGGASSSTGSSNTNASLIVSPNNLNLVDDFQK 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	22/121 (18%)
		ANK	193..335	CDD:238125	37/141 (26%)
		ANK repeat	195..226	CDD:293786	8/30 (27%)
		Ank_5	214..269	CDD:290568	14/54 (26%)
		ANK repeat	228..259	CDD:293786	7/30 (23%)
		ANK repeat	314..345	CDD:293786	9/30 (30%)
		Ank_2	319..412	CDD:289560	35/92 (38%)
		ANK	345..468	CDD:238125	44/125 (35%)
		ANK repeat	347..379	CDD:293786	12/31 (39%)
		ANK repeat	381..412	CDD:293786	13/30 (43%)
		ANK	409..538	CDD:238125	33/160 (21%)
		ANK repeat	414..479	CDD:293786	17/67 (25%)
		ANK repeat	419..445	CDD:293786	7/25 (28%)
		Ank_2	420..511	CDD:289560	25/93 (27%)
		ANK repeat	481..511	CDD:293786	9/29 (31%)
		Ank_2	486..>545	CDD:289560	21/87 (24%)
		ANK repeat	516..542	CDD:293786	10/54 (19%)
AgaP_AGAP011932	XP_320601.4	MIB_HERC2	38..94	CDD:284184
		ZZ_Mind_bomb	106..150	CDD:239079
		MIB_HERC2	177..241	CDD:284184
		ANK repeat	512..575	CDD:293786	23/78 (29%)
		Ank_4	512..564	CDD:290365	18/67 (27%)
		Ank	512..543	CDD:278452	12/46 (26%)
		Ank_2	550..641	CDD:289560	35/91 (38%)
		ANK	572..700	CDD:238125	44/128 (34%)
		ANK repeat	577..608	CDD:293786	12/31 (39%)
		ANK repeat	610..641	CDD:293786	13/30 (43%)
		ANK repeat	643..677	CDD:293786	8/33 (24%)
		Ank_2	648..744	CDD:289560	25/95 (26%)
		ANK	678..826	CDD:238125	31/155 (20%)
		ANK repeat	679..711	CDD:293786	7/31 (23%)
		ANK repeat	713..744	CDD:293786	9/30 (30%)
		Ank_2	718..806	CDD:289560	21/95 (22%)
		ANK repeat	746..806	CDD:293786	12/67 (18%)
		zf-C3HC4_3	925..968	CDD:290631	15/65 (23%)
		zf-C3HC4_3	970..1015	CDD:290631	7/44 (16%)
		zf-C3HC4_3	1139..1182	CDD:290631
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
TreeFam	0	0.000	Not matched by this tool.
	1	1.000