DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42534 and AgaP_AGAP004499

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	XP_003436828.1	Gene:	AgaP_AGAP004499 / 1274645	VectorBaseID:	AGAP004499	Length:	669	Species:	Anopheles gambiae

Alignment Length:	452	Identity:	91/452 - (20%)
Similarity:	145/452 - (32%)	Gaps:	154/452 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 RRLAEGCTSLMYACQRGDIVQVLAQMREKPELLRQRDRSHRNALHYCAAQDSEGSKDLVAAASIA 182
            :|.::||:.|..||:||::...        |.|          :..|.| ||| .|.|.
Mosquito    71 KRTSDGCSPLFIACRRGNVYIT--------EYL----------ITVCEA-DSE-QKGLY------ 109

  Fly   183 IAAPELLESADEDGFTPLHLAVIQGNLAMVNLLLANKADVNAVDNEGHSVVHWATVCGEVESLRA 247
                |:.|.......|||..|.:.|.|.:|..|:...:::||:.:.|.:.:..|.....::.::.
Mosquito   110 ----EVPEDRSVHCVTPLWCACVSGKLPVVKCLVRLGSNINALSDTGSTPLRSACFMTHIDIVQF 170

  Fly   248 VLAAGASVAKPDANGGTPLHYAAQMCGASKQDSKQQASSSNSSRLSLEILGILLSHPQSSVDVQD 312
            ::..||.:.||:.||||.|..:.|                     |:.:...|:|.
Mosquito   171 LVEHGADIRKPNYNGGTCLINSVQ---------------------SVTLCTYLISK--------- 205

  Fly   313 KDGRQPLLWAASAGSAKAVIALVKAGARVESSDKDGLTALHCAGSRGHTECIDTLIGLCGAPTDL 377
                                                                       ||..:.
Mosquito   206 -----------------------------------------------------------GADVNA 211

  Fly   378 IDSNGCTALHYAVTLGHADATARLLDLEADPNRQDRKGRTPAHCGCSKGQFETLKLLKERGANLW 442
            .|....||||||:.....:....||:..|||..:...|.......|.||.:.....||:| .|.
Mosquito   212 RDIQNKTALHYAIQEHRLETAQLLLEHGADPFAKSHYGDDALQTACLKGAYHIFDYLKKR-INY- 274

  Fly   443 LRNAKGDLPLHEAAAS--------GRRELLEWLLAQ----RPKQVNTTSNDGRSLLHIAAANDYT 495
              :|:.....||...|        .|..:|.|.:|.    |..:..|.............|:::|
Mosquito   275 --SAERLADAHELFGSTLIDDLNVTRGAVLHWRMAHQIRLREAEYITKKPPVEPRAAYGFASEFT 337

  Fly   496 DMCKLLLDYGADVNA-------VYRNSRGLVLTPLDGALQRGHRSTAKFLQANGGQPANKVR 550
            .:.: |.:..||::|       :|....|:           .||.|...|...|...|:..|
Mosquito   338 TIPE-LDNIAADMDAMRVQSLLIYERILGI-----------DHRDTLFRLMFRGASYADAHR 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	26/98 (27%)
		ANK	193..335	CDD:238125	25/141 (18%)
		ANK repeat	195..226	CDD:293786	10/30 (33%)
		Ank_5	214..269	CDD:290568	14/54 (26%)
		ANK repeat	228..259	CDD:293786	5/30 (17%)
		ANK repeat	314..345	CDD:293786	0/30 (0%)
		Ank_2	319..412	CDD:289560	14/92 (15%)
		ANK	345..468	CDD:238125	29/130 (22%)
		ANK repeat	347..379	CDD:293786	2/31 (6%)
		ANK repeat	381..412	CDD:293786	11/30 (37%)
		ANK	409..538	CDD:238125	29/147 (20%)
		ANK repeat	414..479	CDD:293786	18/76 (24%)
		ANK repeat	419..445	CDD:293786	7/25 (28%)
		Ank_2	420..511	CDD:289560	23/109 (21%)
		ANK repeat	481..511	CDD:293786	6/36 (17%)
		Ank_2	486..>545	CDD:289560	13/65 (20%)
		ANK repeat	516..542	CDD:293786	5/25 (20%)
AgaP_AGAP004499	XP_003436828.1	Ank_2	<67..147	CDD:289560	27/105 (26%)
		ANK repeat	75..149	CDD:293786	28/103 (27%)
		ANK	121..236	CDD:238125	34/203 (17%)
		Ank_2	123..245	CDD:289560	37/210 (18%)
		ANK repeat	152..182	CDD:293786	5/29 (17%)
		ANK repeat	184..213	CDD:293786	11/117 (9%)
		ANK repeat	215..245	CDD:293786	11/29 (38%)
		ANK	<558..635	CDD:238125
		ANK repeat	578..611	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
TreeFam	0	0.000	Not matched by this tool.
	1	1.000