DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42534 and invs

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	XP_002939636.1	Gene:	invs / 100487895	XenbaseID:	XB-GENE-1221137	Length:	1004	Species:	Xenopus tropicalis

Alignment Length:	1061	Identity:	252/1061 - (23%)
Similarity:	378/1061 - (35%)	Gaps:	295/1061 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 HPPQQEKQEQQQQQQQRQEAADKVIAMPGSSQDTDAAAEAAVDVPETDPDPAQLTVSQSQSSSTV 115
            :|||........|..........::.:.|||             ||......||..:....|...
Frog     3 NPPQGSSLASPVQAAAVTGDKATLLKLIGSS-------------PELIDQEDQLGRTPLMYSVLG 54

  Fly   116 ARRRLAE---------------GCTSLMYACQRG---------------------DIVQVLAQMR 144
            .||..||               |.|:|..|.|.|                     ||..|....|
Frog    55 DRRNCAEALLKHGAQVNRSDRSGRTALHLAAQTGNHRLLKLLLSRKADCTHRDLRDITAVHLSTR 119

  Fly   145 EK-------------PELLRQRDRSHRNALHYCA-------------------AQDSEGS----- 172
            .:             |..:..:|:..:.|||:.|                   ..|:||.
Frog   120 HQDTRCLALLLKYTPPGQVDAQDQRKQTALHWSAYYNRPRHVRLLVRHGSNIGIPDTEGKIPLHW 184

  Fly   173 ----KDLVAAASIAI---AAP--ELLESADEDGFTPLHLAVIQGNLAMVNLLLANK-ADVNAVDN 227
                ||..||.::..   |||  .||...|.:|.|||||||..||..:|.||.:.: .:|...||
Frog   185 AAGHKDPEAALTVRCLLEAAPTESLLNWQDYEGRTPLHLAVGDGNQEVVRLLTSYRGCNVAPYDN 249

  Fly   228 EGHSVVHWATVCGEVESLRAVLAAGASVAKP-DANGGTPLHYAAQMCGASKQDSKQQASSSNSSR 291
            ...:.:|||.:.|.......:|....|...| |:.|.||||||||               .|..
Frog   250 LFRTPLHWAALLGHTPIAHLLLERNNSPNIPSDSQGATPLHYAAQ---------------GNCP- 298

  Fly   292 LSLEILGILLSHPQSSVDVQDKDGRQPLLWAASAGSAKAVIALVKAGARVE--SSDKDGLTALHC 354
               :.:.:||||| |..|..|.:||...:|||..||.:.|..:::....:|  .:||.|.||||.
Frog   299 ---DTVRVLLSHP-SVRDEADLEGRTAFMWAAGKGSDEVVRTMLELDHELEVNRTDKYGGTALHA 359

  Fly   355 AGSRGHTECIDTLIGLCGAPTDLIDSNGCTALHYAVTLGHADATARLLDLEADPNRQDRKGRTPA 419
            |...|....:..|:. .||..|.:|....|.|..|..:||.:..|.|:...|..:..|:.||:|.
Frog   360 ASLSGQITTVRILLE-NGAQVDAVDVMKHTPLFRACEMGHREVIATLVKGGAKVHLVDKDGRSPL 423

  Fly   420 HCGCSKGQFETLKLLKERGANLWLRNAKGDLPLHEAAASGRRELLEWLLAQRPKQVNTTSNDGRS 484
            |.....|.....::|.|...|...::.:|..||..||..|....:| :|.:.....|....:||:
Frog   424 HWAALGGNANVCQILIENNINPDAQDYEGRTPLQCAAYGGYIGCME-VLMENKADPNIQDKNGRT 487

  Fly   485 LLHIAAANDYTDMCKLLLDYGADVNAVYRNSRGLVLTPLDGALQRGHRSTAKFLQANGGQPANKV 549
            .||.:..|.|.|..||||.|.|..|.:......  .||||.||..||:...:|:..:|.
Frog   488 ALHWSCNNGYLDAVKLLLGYSAFPNQMENTEER--YTPLDYALLGGHQEVIQFMLEHGA------ 544

  Fly   550 RLSSRRTGNPFHETNATDMVRPLKYVEKEELHDLRSSKKYVVY----LKRSDSDNGNENGKADVG 610
                                     :....:.|:.:||...||    ::|:..:..|
Frog   545 -------------------------LSIAAIQDIAASKIQAVYKGHKVRRAFQERKN-------- 576

  Fly   611 DGDCSCSEQTYRKEQRLRHVCRRHKRRQLRRRTSSCGESKHE-RCSEI-CRSK-SNIEIRRRKSR 672
                     ...|.::||......||.         |:::|: |..:. |:.: .|:..|:.||.
Frog   577 ---------LLMKHEQLRKGAAAKKRE---------GDNRHKVRVGQTECKQRDENLMERQNKSN 623

  Fly   673 ERYASS--SEWEEESAEDSCENCCYH----KRQKDRVVNRKRSTSSRKSKNR------DSSDPDE 725
            ::..:.  .||..|:..:|.:..|.|    |..:.:.:......|....||:      .||.|:.
Frog   624 QQITNEIVHEWHGEAVGNSEDRECDHQVDNKNIEPKHLKHLEQNSKPTGKNQRRTACVQSSPPEN 688

  Fly   726 KN-----------HSENHSSPEKGSRKPLAVNGDHQADNGKDQTSTKERPPSASRHQTPPT---- 775
            :|           .:.|..|...|:..|:.:|.|   || .....|:.|..|..|.::|..
Frog   689 ENINSVQTRISPSGTSNAQSSSLGNETPIEMNWD---DN-PSHKHTQNRRISRHRMESPDVVVHR 749

  Fly   776 ------KEGTFIKSPTQSAKSEKSGQMDNLLVEESHAVELTDEEQEAAKSVVTQVDVHHDAEEIQ 834
                  ||     |..:|.:.|:.|....   .||....|...|:|.:.||:       ..||.:
Frog   750 IEDLIQKE-----SRKKSHREERKGSHRQ---RESSDNRLCVSERETSNSVI-------QTEEER 799

  Fly   835 TSKSSEEAPQ-AEENGKEKESEQEVKLQLSEEETQLVSKEVEQVIIIAATALSSESKSSSEEKSV 898
            ..|.:::..: |....|.....:.|:|..||:|:::       ||...|..::|
Frog   800 KKKGTKKGRRIATGTSKTGACSEGVRLSQSEKESRV-------VIQGRADCITS----------- 846

  Fly   899 EKELPKEGQAPG----ENHDEEVKEHQNPPTPYAPPAQPSTPPPPPKEEAAKPPSAAEQPQPNAN 959
                |:..:.|.    |......|:.|.|.|                 |..|||..|.|
Frog   847 ----PEPCETPSRVCREKKSSSAKKEQRPLT-----------------ETHKPPGMAYQ------ 884

  Fly   960 TVEGMESAAAEPASVGKKTEQ 980
                  |::|..:|:.:.|.|
Frog   885 ------SSSALKSSMSRHTRQ 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	41/166 (25%)
		ANK	193..335	CDD:238125	51/143 (36%)
		ANK repeat	195..226	CDD:293786	14/31 (45%)
		Ank_5	214..269	CDD:290568	18/56 (32%)
		ANK repeat	228..259	CDD:293786	7/31 (23%)
		ANK repeat	314..345	CDD:293786	9/32 (28%)
		Ank_2	319..412	CDD:289560	29/94 (31%)
		ANK	345..468	CDD:238125	38/122 (31%)
		ANK repeat	347..379	CDD:293786	11/31 (35%)
		ANK repeat	381..412	CDD:293786	8/30 (27%)
		ANK	409..538	CDD:238125	40/128 (31%)
		ANK repeat	414..479	CDD:293786	17/64 (27%)
		ANK repeat	419..445	CDD:293786	5/25 (20%)
		Ank_2	420..511	CDD:289560	28/90 (31%)
		ANK repeat	481..511	CDD:293786	14/29 (48%)
		Ank_2	486..>545	CDD:289560	22/58 (38%)
		ANK repeat	516..542	CDD:293786	9/25 (36%)
invs	XP_002939636.1	ANKYR	<2..135	CDD:223738	26/144 (18%)
		ANK repeat	12..41	CDD:293786	6/41 (15%)
		ANK repeat	44..74	CDD:293786	5/29 (17%)
		ANK repeat	76..142	CDD:293786	11/65 (17%)
		ANK repeat	146..175	CDD:293786	4/28 (14%)
		PHA03095	161..>456	CDD:222980	96/315 (30%)
		ANK repeat	177..214	CDD:293786	11/36 (31%)
		ANK repeat	216..248	CDD:293786	14/31 (45%)
		ANK repeat	250..282	CDD:293786	7/31 (23%)
		ANK repeat	284..312	CDD:293786	16/47 (34%)
		ANK repeat	317..344	CDD:293786	8/26 (31%)
		ANK repeat	352..383	CDD:293786	11/31 (35%)
		ANK repeat	385..416	CDD:293786	8/30 (27%)
		ANK repeat	418..449	CDD:293786	8/30 (27%)
		Ank_2	423..513	CDD:372319	27/90 (30%)
		ANK repeat	451..482	CDD:293786	9/31 (29%)
		ANK repeat	484..512	CDD:293786	13/27 (48%)
		Ank_2	489..>565	CDD:372319	27/108 (25%)
		ANK repeat	517..544	CDD:293786	9/28 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000