DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42534 and nfkb1

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	XP_002934805.3	Gene:	nfkb1 / 100486083	XenbaseID:	XB-GENE-985746	Length:	955	Species:	Xenopus tropicalis

Alignment Length:	685	Identity:	135/685 - (19%)
Similarity:	229/685 - (33%)	Gaps:	233/685 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 NDHPPQQEKQEQQQQQQQRQEAADKVIAMPGSSQDTDAAAEAAVDVPETDPDPAQLTVSQSQSSS 113
            ::..||.|..::..:....|:|.::|:.:   ..||         |.|.:..||
Frog   427 HESQPQCEANQKHVETMNIQDAPNEVVCL---CFDT---------VQENEEAPA----------- 468

  Fly   114 TVARRRLAEGCTSLMYACQRGDIVQVLAQMREKPELLRQRDRSH-RNAL-----HYCAAQDSEGS 172
                                          ||:.|..:..|.:. ||||     |..:..|...:
Frog   469 ------------------------------REEREFCKLHDCNFPRNALQLTKRHAASLFDYAVT 503

  Fly   173 KDLVAAASIAIAAPELLES-ADEDGFTPLHLAVIQGNLAMVNLLLANKA-----DVNAVDNEGHS 231
            .|:    .:.:|....|.| .||:|...|||::|..:.|:|.:.|....     |:..|.|:.:.
Frog   504 GDV----RMLLAVQRHLASIQDENGDNILHLSIIHQHSALVRIFLDITQGPVCDDIINVRNDLYQ 564

  Fly   232 V-VHWATVCGEVESLRAVLAAGASVAKPDANGGTPLHYAAQMCGASKQDSKQQASSSNSSRLSLE 295
            . :|.|.:..:.::::.::.||......|.:|.:.||.|.:...||
Frog   565 TPLHLAVITQQPDTVQDIIKAGGDPLCLDRDGNSVLHLACKEGDAS------------------- 610

  Fly   296 ILGILLSHPQS--SVDVQDKDGRQPLLWAASAGSAKAVIALVKAGARVESSD-KDGLTALHCAGS 357
            .|.|||.|.::  .:::.:.||..|:..|..:.....:..|:.|.|.|.:.: |.|.:|||.|
Frog   611 TLSILLKHKKTLEIINLPNNDGLNPIHVAVLSNCVLCLRLLISARADVNAQEQKSGKSALHLA-- 673

  Fly   358 RGHTECIDTLIGLCGAPTDLIDSNGCTALHYAVTLGHADATARLLDLEADPNRQDRKGRTPAHCG 422
                           ...|.|...||.                ||:.:|..:.....|.||.|..
Frog   674 ---------------VEQDNISLAGCL----------------LLEGDACVDNTTYDGNTPLHIA 707

  Fly   423 CSKGQFETLKLLKERGANLWLRN--------------------AKGDLPLHEAAASGRRELLEWL 467
            ..:|..:...|||..||:.::.|                    ..|..||..|.:.   |:|| :
Frog   708 VGRGSTKLTALLKAAGADSFVENFEPLLRFEDTQDEDDVDEGIVPGTKPLDIATSD---EVLE-I 768

  Fly   468 LAQRPKQVNTTSNDG------RSLLHIAAANDYT-----DMCK----LLLDYGAD-VNAVYRNS- 515
            |..:|.:......|.      ::|........||     |:.|    |....|.. :|..:|.|
Frog   769 LNGKPYKSEVAPEDSLPQGDMKNLSGEVKQRLYTLLESRDLDKNWVTLAQKLGLGMLNNAFRLSP 833

  Fly   516 ------------RGLVLTPLDGALQRGHRSTA--------KFLQANG-GQPANKVRLSSRRTGNP 559
                        .|..:|.|..||:..|.:.|        ..|:.:| ..|:::..|.::|..:|
Frog   834 HPSKTLLDNFEVSGGTMTELLDALKLMHYTEAVEAIEQSQAILKLSGTSTPSSEALLPAQRRDSP 898

  Fly   560 FHETNATDMVRPLKYVEKEELHDLRSSKKYVVYLKRSDSDNGNENGKADVGDGDCSCSEQTYRKE 624
            ..:                           |.|||..|:|:            .|....:|..::
Frog   899 MFD---------------------------VGYLKLQDTDS------------TCDSGVETSFQK 924

  Fly   625 QRLRHVCRRHKRRQLRRRTSSCGE-SKHERCSEIC 658
            ..|.:      ...|:...:.|.: |:...|:.||
Frog   925 LSLSY------SESLKETETVCPKFSQEPDCTLIC 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	25/110 (23%)
		ANK	193..335	CDD:238125	33/149 (22%)
		ANK repeat	195..226	CDD:293786	9/35 (26%)
		Ank_5	214..269	CDD:290568	12/60 (20%)
		ANK repeat	228..259	CDD:293786	4/31 (13%)
		ANK repeat	314..345	CDD:293786	8/30 (27%)
		Ank_2	319..412	CDD:289560	18/93 (19%)
		ANK	345..468	CDD:238125	31/143 (22%)
		ANK repeat	347..379	CDD:293786	6/31 (19%)
		ANK repeat	381..412	CDD:293786	5/30 (17%)
		ANK	409..538	CDD:238125	38/185 (21%)
		ANK repeat	414..479	CDD:293786	20/84 (24%)
		ANK repeat	419..445	CDD:293786	7/25 (28%)
		Ank_2	420..511	CDD:289560	26/126 (21%)
		ANK repeat	481..511	CDD:293786	9/45 (20%)
		Ank_2	486..>545	CDD:289560	18/90 (20%)
		ANK repeat	516..542	CDD:293786	8/33 (24%)
nfkb1	XP_002934805.3	RHD-n	41..239	CDD:415490
		IPT_NFkappaB	246..347	CDD:238582
		Ank_2	509..593	CDD:403870	20/83 (24%)
		ANK repeat	523..560	CDD:293786	10/36 (28%)
		ANK repeat	564..593	CDD:293786	4/28 (14%)
		Ank_2	567..661	CDD:403870	24/112 (21%)
		ANK repeat	595..629	CDD:293786	11/52 (21%)
		ANK repeat	631..662	CDD:293786	8/30 (27%)
		Ank_2	636..725	CDD:403870	27/121 (22%)
		ANK repeat	665..697	CDD:293786	12/64 (19%)
		ANK repeat	699..730	CDD:293786	10/30 (33%)
		Death_NFkB1_p105	796..871	CDD:260063	16/74 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000