DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3339 and DNAH11

DIOPT Version :9

Sequence 1:	NP_001036762.2	Gene:	CG3339 / 43295	FlyBaseID:	FBgn0039510	Length:	4842	Species:	Drosophila melanogaster
Sequence 2:	NP_001264044.1	Gene:	DNAH11 / 8701	HGNCID:	2942	Length:	4516	Species:	Homo sapiens

Alignment Length:	4920	Identity:	2128/4920 - (43%)
Similarity:	2968/4920 - (60%)	Gaps:	518/4920 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AAAMASSDEEGLPAGSTSGRQRVQRDYSDARLERVAAYTTTTMRLKPDKWTKMMACDDLRRIVVE 68
            |..:...:|....|.:...|...|    |||:..:.......:....:||::.:..:|.|:::.|
Human    32 AVELEEEEENEEEAAARRARSFAQ----DARVRFLGGRLAMMLGFTEEKWSQYLESEDNRQVLGE 92

  Fly    69 WQHGHRRVLVMTLSPGGDLVPRSCLSDLYLPYSVQSARGSIPSAMLPAEDEAMATVTAAVSAVVS 133
            :                                                             :.|
Human    93 F-------------------------------------------------------------LES 96

  Fly   134 ATPGALLIPLPPASSSFTTLDGVPRG---KCAYFVRRNTSDGPLTASNFAESVLYGDFPVHSKIE 195
            .:|..|:... .||........:||.   |..:..::.|..  :..::|::.||:|:.|..| :.
Human    97 TSPACLVFSF-AASGRLAASQEIPRDANHKLVFISKKITES--IGVNDFSQVVLFGELPALS-LG 157

  Fly   196 TMSLLFDDVLQPLLEQAQS--QWPAIVRKDLQARIKEVRNTLTEIKGKTNNRTILSLLVSPTIVE 258
            .:|...|::|.|:|....:  .|.....:|::..|:.::..:...:||.:.||:|.:   ||:..
Human   158 HVSAFLDEILVPVLSNKNNHKSWSCFTSQDMEYHIEVMKKKMYIFRGKMSRRTLLPI---PTVAG 219

  Fly   259 EVFAHVSQGHLRPALDPK-FRNLLEEMFINWTTQMHDIVLERSECQPLGSTTQSAGHQPKYITLV 322
            ::....:....:|..:.: ..:.:|.:.|.|:.|:.:|: ||...|.|.:....:
Human   220 KMDLDQNCSENKPPSNERIILHAIESVVIEWSHQIQEII-ERDSVQRLLNGLHLS---------- 273

  Fly   323 SLPAQEIGFWTNRKLNLQNIYEQLRESTHKTLAQILERIESVYYEPYATAFRKLVAAWLEAQDVS 387
              |..|:.||..|:.||..||:||:......:.:||...:|.|:......|..:..|.||||||.
Human   274 --PQAELDFWMMRRENLSCIYDQLQAPVVLKMVKILTTKQSSYFPTLKDIFLAVENALLEAQDVE 336

  Fly   388 LWLQPLLRQTAAFNSVQFSNGHDLVAPLVHIVHLVWSNARYYRSTQRMSVLLRCICNMLVHRAAE 452
            |:|:||.|........:|.....|:|||.|.:.|:||::::|.:..|:.|||:..||:.:::|..
Human   337 LYLRPLRRHIQCLQETEFPQTRILIAPLFHTICLIWSHSKFYNTPARVIVLLQEFCNLFINQATA 401

  Fly   453 DLELQLLFQGDADEGLLKINRTIAVLELFKQRMLDYKERYAGSQVLLPALSEGAAAVASSPSPDD 517
            .|..:.|.:|:.:|.|.|:...:.:|:.||....:|:::.|            :..:.....|.|
Human   402 YLSPEDLLRGEIEESLEKVQVAVNILKTFKNSFFNYRKKLA------------SYFMGRKLRPWD 454

  Fly   518 QQQLWRFCHEDVFGQTLDGFSLQLLELRQVFEAAVQFQQLEKLEVGGLRGKILTERVREIFGEFK 582
            .|....||..|.|   ||    :|:::..:|...::|::||:||.||.:|.||..:|.|:..|..
Human   455 FQSHLVFCRFDKF---LD----RLIKIEDIFATTLEFEKLERLEFGGTKGAILNGQVHEMSEELM 512

  Fly   583 ---VLFEQWSNVDIDLTATVASKWKCFRREQTLFFSRMQLLEQKLATVLLQAFEQCHSWMHLLRL 644
               .||:|.:....|.|...      |..:...|.|:....:::|.|::.:||..|:......:|
Human   513 ELCKLFKQSTYDPSDCTNME------FESDYVAFKSKTLEFDRRLGTIICEAFFNCNGLEAAFKL 571

  Fly   645 TLMFGSLLQREAVRPELARVLPHILFIYDTEME---QL-EDSVGEVLLGYEIRGLAALPLANNFP 705
            ..:||:.|::..|....:.....::.:::||::   || .:.:.::..|:.:       |..|.|
Human   572 LTIFGNFLEKPVVMEIFSLHYSTLVHMFNTELDVCKQLYNEHMKQIECGHVV-------LNKNMP 629

  Fly   706 PIANAMMWLEQHISRCDEFGAKELSQLVEQLLKEKSELQTLPIQWNSLLSRRNI----------- 759
            ..:..|.|.:|                         .||.|.:.|::..|.|.:
Human   630 FTSGNMKWAQQ-------------------------VLQRLQMFWSNFASLRYLFLGNPDHALVY 669

  Fly   760 -----LTTKLSNLQMKIWISWHECVDKLIIQGLDESVLSRSQDLSQLHLNFSQVLFTLLKETKYL 819
                 :||.|...:.:|:..|...||::....|::.::..|.....|.:||...|..:|:|.|||
Human   670 QKYVEMTTLLDQFESRIYNEWKSNVDEICEFNLNQPLVKFSAINGLLCVNFDPKLVAVLREVKYL 734

  Fly   820 LALQATGSLSGDLFQLPEPLLTLYGHRDAYWERRIRLIKIGEFYNGIRSGECAAAELQLIRNDLA 884
            |.|:..        .:|:..|.::..|:...:....|..:.:.||.::. .....|..||.::|.
Human   735 LMLKKQ--------DIPDSALAIFKKRNTILKYIGNLDLLVQGYNKLKQ-TLLEVEYPLIEDELR 790

  Fly   885 SIDEHVEVACQQLTWRNYNDELVAGIFEQSRDLFARLQQSHGNLDAILASMRRWSREPLHQRSLY 949
            :|||.:..|...|||::.....:..:...:.:|..|::::..|:..|..:||.|:|..|..|..:
Human   791 AIDEQLTAATTWLTWQDDCWGYIERVRAATSELEHRVERTQKNVKVIQQTMRGWARCVLPPRREH 855

  Fly   950 GRN-LLDLRHQQD--RVRLRLLQCDETKMLLNRLLIANFCLFFNYESQEFQLYSRDLSVQEFIRE 1011
            .|. ...|..:.|  ..:.:|:|.|.             |...|...:..:|:..:.|:.
Human   856 RREAAFTLEDKGDLFTKKYKLIQGDG-------------CKIHNLVEENRKLFKANPSLD----- 902

  Fly  1012 FPEEQRRQYNKYLASVDELICREVREAMRISLEYLYKEMTATATATTTPTAPPVDPGCSAGMARL 1076
                   .:..|:..:|:::.....:|:...|::..|.           |...:.|
Human   903 -------TWKIYVEFIDDIVVEGFFQAIMHDLDFFLKN-----------TEKQLKP--------- 940

  Fly  1077 VLQQITTPQATSTAGAGASGAPPTANDAPLFEVKLELTETEIRFSPAFDASVENNFQQIVEQLLL 1141
                                       ||.|:.::.|...||.|.|:.|....:.|..:||::|.
Human   941 ---------------------------APFFQAQMILLPPEIVFKPSLDREAGDGFYDLVEEMLC 978

  Fly  1142 DIKQTCDCMPRIVADNAPSEDDEDDDTATVDYEQELRWEPREDRAQELQERKKKDLELEQEQGDP 1206
            :..:....|.||..                                        .||::..|.|
Human   979 NSFRMSAQMNRIAT----------------------------------------HLEIKNYQND- 1002

  Fly  1207 KPQAVQFNLLAAAKAYSQKMECTADGLEMLERAIRDALADTVAAASAYAAKFQAYAFLWTQQSSE 1271
                 ..|:|               ||..:.:.|.:.:.:.:.....:....:.:.:||....:|
Human  1003 -----MDNML---------------GLAEVRQEIMNRVVNVINKVLDFRNTLETHTYLWVDDRAE 1047

  Fly  1272 VLAACMQTAREQTHHVSAGGYAI-------------------METFKKEIENYNEVHDAIDQCEN 1317
            .:           .|....|:|:                   :|.||::|:.|..::..:.:.|:
Human  1048 FM-----------KHFLLYGHAVSSDEMDAHANEEIPEQPPTLEQFKEQIDIYEALYVQMSKFED 1101

  Fly  1318 RECINGWLALDIKPLKYGLLNLACKWSHMCKKWLLRYVQGTLKELNAFIARGFETLQLHIARQDF 1382
            ....:.|..:|:||.|..||.:..|||.|.::.|||:|..:|.||..||......||..:...|.
Human  1102 FRVFDSWFKVDMKPFKVSLLTIIKKWSWMFQEHLLRFVIDSLNELQEFIKETDSGLQRELNEGDH 1166

  Fly  1383 ATLLRVLAIMSEIREREPYADNVFKPLKEIMGLLKTYNVEFEPQLLRGIEQLPQQWQQLKH-SST 1446
            ..|:.::..:..:|.|:...|.:|:||||.:.||::|..:...|:...:|:||::|:..|. ::|
Human  1167 DGLVDIMVHLLAVRSRQRATDELFEPLKETITLLESYGQKMPEQVYIQLEELPERWETTKKIAAT 1231

  Fly  1447 VKQEALQDTRFHQQQRVTALIGLHTCHL------------QHYARQFQKMPF-FRVPCPQVYDVC 1498
            |:.|.   :..|..: ||.:  ...|.|            :|||      |. |....|  |...
Human  1232 VRHEV---SPLHNAE-VTLI--RKKCILFDAKQAEFRERFRHYA------PLGFNAENP--YTAL 1282

  Fly  1499 DEVYLRLHRFRRQQRLYTRWARLLDIQPPDPATLQFCEVELRRVKQLWDFVRVIESCIVAWHATP 1563
            |:....|.....:........||.::..|:...::.|..|::.:|.|||.:..:...|..|..|.
Human  1283 DKANEELEALEEEMLQMQESTRLFEVALPEYKQMKQCRKEIKLLKGLWDVIIYVRRSIDNWTKTQ 1347

  Fly  1564 WLLIDTDDMEHECKKFTRDLRTLDKCIREWAPYVHIVGVLRELVASLRAITELQNPAITERHWME 1628
            |..|..:.|:.|.::|.:::.:|:|.:|.|..|..:.|.::::.||||||||||:||:.:|||.:
Human  1348 WRQIHVEQMDVELRRFAKEIWSLNKEVRVWDAYTGLEGTVKDMTASLRAITELQSPALRDRHWHQ 1412

  Fly  1629 LMQLTKLSYKCNKSTRLAQLLTLQLQHHEEDIKNTVDRAIKEMTVTKVLDEIKATWAHLEFELEQ 1693
            ||:...:.:..|::|.||.||.|:|...|:|::..||:|:||:...||:.||..|||.::|..|.
Human  1413 LMKAIGVKFLINEATTLADLLALRLHRVEDDVRRIVDKAVKELGTEKVITEISQTWATMKFSYEV 1477

  Fly  1694 HHTRPHIQLLKVSEELIETLDDNQMQLQNISTSKHIEYLLDKLTHWQKVLGGIDTLIVNWFEVQR 1758
            |: |..|.|||..|:|.|||:.||:|||.:..||::||.::::..||..|...|.:|..|.||||
Human  1478 HY-RTGIPLLKSDEQLFETLEHNQVQLQTLLQSKYVEYFIEQVLSWQNKLNIADLVIFTWMEVQR 1541

  Fly  1759 KWIYLECIFIGSADIRAQLPADAANFERIDEDFTALLAKVQEVRVVMQVVLRHDDVLAQLLQLQH 1823
            .|.:||.||:.|.|||.||..||..|:.:|.:|..|:.|..:|..|::...| .::..:|..||.
Human  1542 TWSHLESIFVCSEDIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCR-PNLYEKLKDLQS 1605

  Fly  1824 RLAVCEKALNDYLETKRLAFPRFYFISAADLLDILSNGNNPQVIDRHLIKLFDSILRLQYETN-- 1886
            ||::|||||.:||||||:|||||||:|:||||||||.|..|:.:..||.||||||..||:|.|
Human  1606 RLSLCEKALAEYLETKRIAFPRFYFVSSADLLDILSKGAQPKQVTCHLAKLFDSIADLQFEDNQD 1670

  Fly  1887 --TPNALGMHSKENDEYVPFVSFDPDQPAFIVCGGRVELWLRAIIQQMRSTLHELFRRALRVFGE 1949
              ...|:||:|||. |||||       .|...|.|.||.||..:.|.|:.|:......|:..:.|
Human  1671 VSAHRAVGMYSKEK-EYVPF-------QAECECVGHVETWLLQLEQTMQETVRHSITEAIVAYEE 1727

  Fly  1950 KPRELWLYDWPAQVALCCSQISWTADVNRSFGCMEEGYEGVMKELHKRQIAQLNALINLLLGELS 2014
            ||||||::|:||||||..|||.||.||..:|..:|||||..:|:.||:||:|||.||.||||||.
Human  1728 KPRELWIFDFPAQVALTSSQIWWTTDVGIAFSRLEEGYETALKDFHKKQISQLNTLITLLLGELP 1792

  Fly  2015 PGDRQKIMTICTIDVHSRDVVGKIIASKVDNSLAFQWQSQLRHRWDDDQAGSSSGRASTAISCGG 2079
            ||||||||||||||||:||||.|:|:.||.:..||.|.|||||||:|.|
Human  1793 PGDRQKIMTICTIDVHARDVVAKLISQKVVSPQAFTWLSQLRHRWEDTQ---------------- 1841

  Fly  2080 GDEDCFANICDAEFRYAYEYLGNTSRLVITPLTDRCYITLTQSLRLRLAGATAGPAGTGKTETTK 2144
              :.||.|||||:|:|.||||||:.|||||||||||||||||||.|.::||.|||||||||||||
Human  1842 --KHCFVNICDAQFQYFYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTK 1904

  Fly  2145 DLGRALGVMVYVFNCSEQMDYKSCGNIYKGLAQTGAWGCFDEFNRICVEVLSVVAVQVKTIQEAI 2209
            |||||||:|||||||||||||||.|||||||.||||||||||||||.||||||||||||.|.:||
Human  1905 DLGRALGMMVYVFNCSEQMDYKSIGNIYKGLVQTGAWGCFDEFNRISVEVLSVVAVQVKMIHDAI 1969

  Fly  2210 KMHKTQFIFMGERISLEPSVGIFITMNPGYAGRTELPENLKTLFRPCAMIVPDFALICEIMLMAE 2274
            :..|.:|:|:||.|:|:||||||||||||||||||||||||.|||||||:.||..|||||:|:||
Human  1970 RNRKKRFVFLGEAITLKPSVGIFITMNPGYAGRTELPENLKALFRPCAMVAPDIELICEILLVAE 2034

  Fly  2275 GFQDARLLARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGTLKRDDHSRPEDQVLMRALRD 2339
            ||.|||.|||||||||||||||||||||||||||||||||||||:|||.|.:|||||||||||||
Human  2035 GFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLMRALRD 2099

  Fly  2340 FNIPKIVTEDVPIFMGLIGDLFPALDVPRKRVFEFEKTIRRAVNEIKLQPEEGFLMKVVQLQELL 2404
            ||:|||||:|:|:|:||:|||||||||||:|...||:.:|::..|::|||||.|::|||||:|||
Human  2100 FNMPKIVTDDIPVFLGLVGDLFPALDVPRRRKLHFEQMVRQSTLELRLQPEESFILKVVQLEELL 2164

  Fly  2405 DVRHSVFIVGNAGTGKTKIWQTLRETYRIQKLKPVCHVLNPKALSNDELFGIVNPTTREWKD--- 2466
            .||||||:||||||||:||.:||..||...|.|||.:.|||||::.|||||.::..||||||
Human  2165 AVRHSVFVVGNAGTGKSKILRTLNRTYVNMKQKPVWNDLNPKAVTTDELFGFIHHATREWKDGKI 2229

  Fly  2467 ------GLFSSIMREQANMPPGNPKWIVLDGDIDPMWIESLNTLMDDNKILTLASNERISLKREM 2525
                  ||||||:|||||:....||||||||||||||||||||:|||||:|||||||||:|...|
Human  2230 VYSYFIGLFSSILREQANLKHDGPKWIVLDGDIDPMWIESLNTVMDDNKVLTLASNERIALTPFM 2294

  Fly  2526 RLLFEVGHLKAATPATVSRAGILYINPQDLGWSPYVSSWLETRVDMIERGILNALFEKYFP-CLM 2589
            |||||:.||::|||||||||||||:|||||||:|||:||::.|....|:..|..||:||.| ||.
Human  2295 RLLFEIHHLRSATPATVSRAGILYVNPQDLGWNPYVASWIDRRRHQSEKANLTILFDKYVPACLD 2359

  Fly  2590 QRQRDFRRITPITDMAMIQMTCHLLECLLDSDEGNADGRGRGSATGGAANPHSLHHGELSHEAMV 2654
            :.:..|:.||.|.:.:::|..|.||||||..:...:|            :|..::
Human  2360 KLRTSFKTITSIPESSLVQTLCVLLECLLTPENVPSD------------SPKEVY---------- 2402

  Fly  2655 MALETIFVYATVWSFGSALSQDVIIDWHREFHKWWIGEFKDIKLPSQGTVFDYQLNVQTLKFQPW 2719
               |..||:|.:|:||..|.||.|.|:..:|.:||..|.|.:|.|||||:|||.::.:|.|..||
Human  2403 ---EVYFVFACIWAFGGTLLQDQISDYQADFSRWWQKEMKAVKFPSQGTIFDYYVDHKTKKLLPW 2464

  Fly  2720 SELAAHQSLEGQIDSETPLQNVLISTAETIRLAYFLKLLIDRNLACMLVGNSGCGKGAIFRQLFG 2784
            ::..|..::    |.:.|||.||:.|.||.||.||::||:::....|||||:|.|| .:|
Human  2465 ADKIAQFTM----DPDVPLQTVLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGK-TVF----- 2519

  Fly  2785 QYANDQELLEVAVSAATAGDSSHQQQSGNPAGAVVVRRKASSSATPLLTTVQATHFNFYTSSEIF 2849
                             .||:                 .||.|...:::.|.   ||:||:|...
Human  2520 -----------------VGDT-----------------LASLSEDYIVSRVP---FNYYTTSTAL 2547

  Fly  2850 QKMLDRPLEKKSGRCYAPSGPKRRLIYFVNDLNMPEVDAYGTVQPHTIMRQFMDYRQWYDRQRLQ 2914
            ||:|::|||||:|..|.|.|.| :||||::|:||||||.||||||||::||.:||..|||||::.
Human  2548 QKILEKPLEKKAGHNYGPGGNK-KLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVM 2611

  Fly  2915 LKDIRHCQFAACMNPTAGSFTIDPRLQRHFCVFSVAPPGEDTLHHIYGSILSSHLESPSQGFTKE 2979
            ||:|.:||:.|||||..|||||:|||||||.||:...|..|.|:.|||.|.|.|.:  .|.|...
Human  2612 LKEIHNCQYVACMNPMVGSFTINPRLQRHFTVFAFNFPSLDALNTIYGQIFSFHFQ--QQAFAPS 2674

  Fly  2980 IRSIGSLLVRVGIALHRRVEYAFLPTALKFHYLFNLRDLTGIYQGLMNSVGAPASAGGGGASGFG 3044
            |...|..|::..||.|:.:...|||||:||||:||||||:.::||::                |.
Human  2675 ILRSGPTLIQATIAFHQTMMCNFLPTAIKFHYIFNLRDLSNVFQGIL----------------FA 2723

  Fly  3045 GTICSR-PSELMRLYVHEAFRVYHDRLVDPYDIKSFKSSIRDIFKKDFEDFDEDFVFAEPLIYSH 3108
            ...|.: |.:|:.|::||:.|||.|:|:|..|...|:..:.:...|.||..|...:..:||||.|
Human  2724 SPECLKGPLDLIHLWLHESARVYGDKLIDKKDCDLFQRRMLETAYKYFEGIDSHMLLQQPLIYCH 2788

  Fly  3109 FAQSLVDQKYMPLKSWDSLYQLLIEAQASYNEVVGYMNLVLFEDAMIHVCRINRILESPRGNALL 3173
            ||....|..|||:|.|:.|..:|.|...:|||:...|:||||||||.|||||:|||.:|:|.|||
Human  2789 FADRGKDPHYMPVKDWEVLKTILTETLDNYNELNAAMHLVLFEDAMQHVCRISRILRTPQGCALL 2853

  Fly  3174 IGVGGSGKQTLARLAAFISSLNVSQIQIKRGFGLLDMREEIGNLYMKVGLKNLASVFLISDAQIP 3238
            :||||||||:|:||||::..|.|.||.:..|:|:.::|.::.|||::.|.||:.:|||::|||:.
Human  2854 VGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAKNMPTVFLLTDAQVL 2918

  Fly  3239 DESILMLINDLLASGEIPELFNDDQLDTITNGIRNEVKQSGTLDTKENCWRYFVEKVRRLLKVVL 3303
            |||.|:||||||||||||:||:|:.:|.|.:||.|||...|.:|::||||::|:.:||..||::|
Human  2919 DESFLVLINDLLASGEIPDLFSDEDVDKIISGIHNEVHALGMVDSRENCWKFFMARVRLQLKIIL 2983

  Fly  3304 CFSPVGQTLRVRARKFPAIISRTAIDWFHEWPKSALESVSQKFLNEINGILEPALVPPIGCFMAY 3368
            ||||||:||||||||||||::.|||||||.||:.||.|||::|:.|..|| ||.....|..|||:
Human  2984 CFSPVGRTLRVRARKFPAIVNCTAIDWFHAWPQEALVSVSRRFIEETKGI-EPVHKDSISLFMAH 3047

  Fly  3369 VHGTVNQISRIYLQNEKRYNYTTPKTFLEYIFLYRKLLVDKNGEFAERIARLQSGMSKLAECARQ 3433
            ||.|||::|..|.|||:|:||||||:|||.|.|::.||..|..|.:|:..||.:|:.||...|.|
Human  3048 VHTTVNEMSTRYYQNERRHNYTTPKSFLEQISLFKNLLKKKQNEVSEKKERLVNGIQKLKTTASQ 3112

  Fly  3434 VDTLKHQLAIQEVQLAAKNAAADKLIVIVSAESEKVKRERYIASEEEKRVRIIEEDVSIKTKMCE 3498
            |..||.:||.||.:|..:|..|:.||..:..::|||.||:.||..||::|..|:.:|..|.:.||
Human  3113 VGDLKARLASQEAELQLRNHDAEALITKIGLQTEKVSREKTIADAEERKVTAIQTEVFQKQRECE 3177

  Fly  3499 EDLRQAEPALVAAQAALNTLNKNNLTELKSFGSPPKAVVNVCAAVMVLLASNGKIPRDRSWKASK 3563
            .||.:||||||||.|||||||:.||:|||:|.:||.||.||.||||||||..|::|:||||||:|
Human  3178 ADLLKAEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLAPRGRVPKDRSWKAAK 3242

  Fly  3564 LMMVRVDQFLNDLLNYNKDNIHPNIIETLQE-YLKDPEFNPDKVVQKSVAAAGLCAWVINLHRYH 3627
            :.|.:||.||..|:||:|::|..|.::.:.| |||||||||:.:..||.|||||||||||:.:::
Human  3243 VFMGKVDDFLQALINYDKEHIPENCLKVVNEHYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFY 3307

  Fly  3628 QVFLIVGPKQQALQDSHQELLEARERLQYLKAKINNLEAKLAEIQAEFENAVGEKQRCQREADKT 3692
            :|:..|.||:|||..::.||..|.|:|:.::.|:.:|:..|:.:.|.||.|..||.|||.|.::|
Human  3308 EVYCDVEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQT 3372

  Fly  3693 AFTIDLAHRLVNGLANENVRWKESVQSLLAKIGTLPGDILLISSFLSYVGCFTRRYREELQHKMW 3757
            ..||.||:|||..|..:.:||.:|::|..|:..||.||:||.::|:||||.|||:||:||.|..|
Human  3373 NKTIKLANRLVKELEAKKIRWGQSIKSFEAQEKTLCGDVLLTAAFVSYVGPFTRQYRQELVHCKW 3437

  Fly  3758 LPNFRKIDPHIPHTEGVDTLALFSDDAQIAAWNNEGLPMDRMSTENATILQYSTRWPLMIDPQLQ 3822
            :| |.:....||.|||:|.:::.:|||.||||||||||.||||||||.||.:..||||:||||.|
Human  3438 VP-FLQQKVSIPLTEGLDLISMLTDDATIAAWNNEGLPSDRMSTENAAILTHCERWPLVIDPQQQ 3501

  Fly  3823 GIKWIKNRFGTDLVVLRLRQKGFLEALEKSISQGDTVLIEQIEESMDTVLEPLLSRALIKKGRYL 3887
            |||||||::|.||.|..|.|||||.|:|.:::.||.:|||.:||::|.||:|||.|..||||:|:
Human  3502 GIKWIKNKYGMDLKVTHLGQKGFLNAIETALAFGDVILIENLEETIDPVLDPLLGRNTIKKGKYI 3566

  Fly  3888 RIGDKEIEFHASFRLILHTKMANPHYKPEMQAQTTLINFTVTPDGLEEQLLAEVVKIERPDLEQM 3952
            ||||||.||:.:||||||||:||||||||:||||||:|||||.||||.|||||||.|||||||::
Human  3567 RIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAEVVSIERPDLEKL 3631

  Fly  3953 KTEVTVQQNKFKISLKALEDELLARLASSGENVLDDHALVINLENTKRTVDEIEAKVREARVTTL 4017
            |..:|..||.|||.||.|||:||.||:::..:.|||..||..||.||.||.|||.||.||:....
Human  3632 KLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEIEHKVIEAKENER 3696

  Fly  4018 QIDDTRNIYRSAAKRAAILYFVLTDLSRINPIYKFSLKSFMNVFRQAIAMAAESKNYEKRVLHLV 4082
            :|::.|..||..|.||::||||:.||.:|||:|:||||:|..:|.:||..|.:.::.:.|:..|:
Human  3697 KINEARECYRPVAARASLLYFVINDLQKINPLYQFSLKAFNVLFHRAIEQADKVEDMQGRISILM 3761

  Fly  4083 ESITLQTYRYTLRGLFEADKLTFTSHMTLRILIAAEQVAKDETDFLLRFPHDPTTLSPLDFVGRS 4147
            ||||...:.||.:.|||.|||||.|.|..:||:..:::...|.||||||..:.|.|||:||:...
Human  3762 ESITHAVFLYTSQALFEKDKLTFLSQMAFQILLRKKEIDPLELDFLLRFTVEHTHLSPVDFLTSQ 3826

  Fly  4148 AWGGIKSLTLIEHFYGIDKDMENYTKRWRKFMASDTPEREQFPGEWKHRTPLQKLCIIRSLRPDR 4212
            :|..||::.::|.|.|||:|:|...|:|||::.|:.||:|:.|.|||.::.:|||.::|::||||
Human  3827 SWSAIKAIAVMEEFRGIDRDVEGSAKQWRKWVESECPEKEKLPQEWKKKSLIQKLILLRAMRPDR 3891

  Fly  4213 MTYAMRQFVEQTMGRSYAEIQTPPFGAIFQELNAATPAFFILSPGVDPIRDVERYGQRQGFHSES 4277
            ||||:|.|||:.:|..|.|.........|:|.:.|||.|||||||||.::|:|..|:|.||..:|
Human  3892 MTYALRNFVEEKLGAKYVERTRLDLVKAFEESSPATPIFFILSPGVDALKDLEILGKRLGFTIDS 3956

  Fly  4278 DTLVNISLGQGQELLAEQAIIGALESGQQWVILQNIHLVVNWLPTLEKLIERIVLQSESKG-ESN 4341
            ....|:|||||||.:||.|:..|.:.| .||||||:|||..||.|||||:||.     |:| ..:
Human  3957 GKFHNVSLGQGQETVAEVALEKASKGG-HWVILQNVHLVAKWLGTLEKLLERF-----SQGSHRD 4015

  Fly  4342 FRLFISAEPAPDPQYHVIPQGILESSLKVVNEPPSGMAANLHKAWDNFSQDALETCTQEAEFKSI 4406
            :|:|:|||.||.|..|:||||:||:|:|:.||||:||.||||.|..||.||.||.|::|.|||||
Human  4016 YRVFMSAESAPTPDEHIIPQGLLENSIKITNEPPTGMLANLHAALYNFDQDTLEICSKEQEFKSI 4080

  Fly  4407 LFALCYFHAVAGERRKFGPQGWNKVYPFNIGDLTISSNVLHNYLEGSNRIPWEDLRYLFGEIMYG 4471
            ||:||||||....|.:||||||::.||||.|||||.::||:||||.::::|||||||||||||||
Human  4081 LFSLCYFHACVAGRLRFGPQGWSRSYPFNPGDLTICASVLYNYLEANSKVPWEDLRYLFGEIMYG 4145

  Fly  4472 GHITDDWDRRLCQTYLEELLQQDLIDGDFELCPGFPAPPNLDFEGYHSYITEMLPEESPLLYGLH 4536
            |||||||||:||:.||||.:...|.:.:..|.|||.|||.||:.|||.||.||||.|||.|||||
Human  4146 GHITDDWDRKLCRVYLEEFMNPSLTEDELMLAPGFAAPPYLDYAGYHQYIEEMLPPESPALYGLH 4210

  Fly  4537 PNAEIGFLTTASEQLLRTIFELQPRESELSSHCGAPREELVKIMIDDFLDKLQDEFNLQALLNRV 4601
            |||||.|||..|..|.||:.|:|||.:......|...||.||.::||.|:||.:|||:..::.:.
Human  4211 PNAEIEFLTVTSNTLFRTLLEMQPRNALSGDELGQSTEEKVKNVLDDILEKLPEEFNMAEIMQKN 4275

  Fly  4602 ERKTPFVVVALQECERMNALIREIKRSLRELMLGLRGELTITQEMERLDHAIFYDHVPAAWARLA 4666
            ..::|:|:|..|||||||.|||||:.||.:|.|.|:|||.::..:|....|:.||.||..|::||
Human  4276 SNRSPYVLVCFQECERMNILIREIRISLEQLDLSLKGELALSPAVEAQQFALSYDTVPDTWSKLA 4340

  Fly  4667 YPSMLGLQSWFADLLHRIKELAGWLNDFKLPCAIWLGGLFNPQSFLTAIMQESARKHDLPLDRML 4731
            |||..||..||.|||.|.:||..|..|..||..:||.|.||||||||||||..|||::.|||:..
Human  4341 YPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWLSGFFNPQSFLTAIMQTMARKNEWPLDKTR 4405

  Fly  4732 ISCDVTKKQKDDVTLPPMEGAFVHDLYMDGASWDCQLNSIVALRPKEMLCAMPVIYIKSIVQEKQ 4796
            ::.|||||.|:|...||.|||::|.|:|:||.||.|..:||..|.||:.|.||||:.|:...::|
Human  4406 LTADVTKKTKEDYGHPPREGAYLHGLFMEGARWDTQAGTIVEARLKELACPMPVIFAKATPVDRQ 4470

  Fly  4797 ELQRVYECPLYKTRSRGNTYVWTFNLKTRERPSRWILGGVALLLQ 4841
            |.::.||||:|:|:.||.:|:|||.||:.|:.::|:|.||||||:
Human  4471 ETKQTYECPVYRTKLRGPSYIWTFRLKSEEKTAKWVLAGVALLLE 4515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3339	NP_001036762.2	DHC_N1	276..903	CDD:285571	161/650 (25%)
		DHC_N2	1535..1944	CDD:285579	179/412 (43%)
		P-loop_NTPase	2095..2324	CDD:304359	193/228 (85%)
		P-loop_NTPase	2409..2544	CDD:304359	97/143 (68%)
		P-loop_NTPase	2731..3061	CDD:304359	139/330 (42%)
		P-loop_NTPase	3138..3406	CDD:304359	159/267 (60%)
		MT	3419..3759	CDD:289543	173/340 (51%)
		AAA_9	3789..4001	CDD:289547	142/211 (67%)
		Dynein_heavy	4142..4832	CDD:281078	372/690 (54%)
DNAH11	NP_001264044.1	Stem. /evidence=ECO:0000250	1..1854		596/2158 (28%)
		DHC_N1	239..812	CDD:285571	161/651 (25%)
		DHC_N2	1319..1722	CDD:285579	179/412 (43%)
		P-loop_NTPase	1855..2084	CDD:304359	193/228 (85%)
		AAA 1. /evidence=ECO:0000250	1855..2076		186/220 (85%)
		AAA 2. /evidence=ECO:0000250	2136..2366		145/229 (63%)
		P-loop_NTPase	2169..2313	CDD:304359	97/143 (68%)
		P-loop_NTPase	2471..2741	CDD:304359	139/335 (41%)
		AAA 3. /evidence=ECO:0000250	2472..2719		132/296 (45%)
		AAA 4. /evidence=ECO:0000250	2817..3066		147/249 (59%)
		P-loop_NTPase	2818..3085	CDD:304359	159/267 (60%)
		Stalk. /evidence=ECO:0000250	3072..3403		163/330 (49%)
		MT	3097..3441	CDD:289543	174/344 (51%)
		AAA 5. /evidence=ECO:0000250	3459..3686		152/226 (67%)
		AAA_9	3468..3680	CDD:289547	142/211 (67%)
		Dynein_heavy	3820..4506	CDD:281078	372/691 (54%)
		AAA 6. /evidence=ECO:0000250	3896..4122		128/231 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11693
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56441
OrthoDB	1	1.010	-	-		D1463at33208
OrthoFinder	1	1.000	-	-		FOG0000396
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	1	1.100	-	-	O	PTHR10676
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.830