Protein Alignment CG3339 and DYNC1H1

DIOPT Version :9

• Sequence 1: NP_001036762.2
• Gene: CG3339 / 43295
• FlyBaseID: FBgn0039510
• Length: 4842
• Species: Drosophila melanogaster
• Sequence 2: NP_001367.2
• Gene: DYNC1H1 / 1778
• HGNCID: 2961
• Length: 4646
• Species: Homo sapiens
• Alignment Length: 5072
• Identity: 1252/5072 - (24%)
• Similarity: 2190/5072 - (43%)
• Gaps: 967/5072 - (19%)

  Fly   183 VLYGDFPVHSKIETMSLLFD---DVLQPLLEQAQSQ-WPAIVRK-------------DLQARIKE 230
            |:..|.||.|::..::|..|   :.|...:..|.:. :.:.:|:             .::.:|.|
Human   124 VIDADKPVSSQLRVLTLSEDSPYETLHSFISNAVAPFFKSYIRESGKADRDGDKMAPSVEKKIAE 188

  Fly   231 VRNTLTEIKGKTNNRTI--LSLLVSPTIVEEVFAHVSQGHLRPAL--------DPKFRNLLEEMF 285
            :...|..::   .|..|  :||.:.|.|.........:|. :|.:        ||.|.|.|:...
Human   189 LEMGLLHLQ---QNIEIPEISLPIHPMITNVAKQCYERGE-KPKVTDFGDKVEDPTFLNQLQSGV 249

  Fly   286 INWTTQMHDIV-LERSECQPLGSTTQSAGHQPKYITLVSLPAQEIGFWTNRKLNLQNIYEQLRES 349
            ..|..::..:. |:|   .|...|.                .|||.||.|.:..|..|.|: |||
Human   250 NRWIREIQKVTKLDR---DPASGTA----------------LQEISFWLNLERALYRIQEK-RES 294

  Fly   350 T---------------HKT--------LAQILERIESVYYEPYATAFRKLVAAWLEAQDVSLWLQ 391
            .               |.|        |.|.||.:..  |.|....|.               |.
Human   295 PEVLLTLDILKHGKRFHATVSFDTDTGLKQALETVND--YNPLMKDFP---------------LN 342

  Fly   392 PLLRQTAAFNSVQFSNGHDLVAPLVHIVHLVWSNARYYRSTQRMSVLLRCICNMLVHRAAEDLEL 456
            .||..|......|     .|||...|:..:  .|.:|  ..||   .||     ||...:.||..
Human   343 DLLSATELDKIRQ-----ALVAIFTHLRKI--RNTKY--PIQR---ALR-----LVEAISRDLSS 390

  Fly   457 QLL-------FQGDADEGLLKINRTIAVLELFKQRMLDYKERYAGSQVLLPALSEGAAAVASSPS 514
            |||       ....|.|...|:  .:|..|:|:    .:.:.|...||||       ..:.....
Human   391 QLLKVLGTRKLMHVAYEEFEKV--MVACFEVFQ----TWDDEYEKLQVLL-------RDIVKRKR 442

  Fly   515 PDDQQQLWRF--CHEDVFGQTLDGFSLQLLELRQVFEAAVQFQQLEKLEVGGLRGKILT------ 571
            .::.:.:||.  .|..:..: ||    |:.:.|:      |.:||..:.|..||.::..
Human   443 EENLKMVWRINPAHRKLQAR-LD----QMRKFRR------QHEQLRAVIVRVLRPQVTAVAQQNQ 496

  Fly   572 --------ERVREI---------FGEFKVLFEQWSNVD-IDLTATVASKWKCFRREQTLFFSRMQ 618
                    .:|.|:         ..|..:.:|....|| :|::......|:...:.   :..|:.
Human   497 GEVPEPQDMKVAEVLFDAADANAIEEVNLAYENVKEVDGLDVSKEGTEAWEAAMKR---YDERID 558

  Fly   619 LLEQKLATVLLQAFEQCHSWMHLLRLTLMFGSLLQREAVRPELARVLPHILFIYDTEMEQLEDSV 683
            .:|.::...|........:...:.|:...|.:|..|..:|..:......::.....::|.|.|
Human   559 RVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGAIREYQTQLIQRVKDDIESLHD-- 621

  Fly   684 GEVLLGYEIRGLAALPLANNFPPIANAMMWLEQ-------HISRCDEFGAKELSQLVE-QLLKE- 739
             :..:.|.......:....:.||::.:::|.:|       ::.|.::...|.....|| |.||:
Human   622 -KFKVQYPQSQACKMSHVRDLPPVSGSIIWAKQIDRQLTAYMKRVEDVLGKGWENHVEGQKLKQD 685

  Fly   740 ----KSELQTLPI--QWNSLLSRRNILTTKLSNLQMKIWISWHECVDKLIIQGLDESVLSRSQDL 798
                :.:|.|..|  .|...:.:||:      .:..:|:     .::...::|       |:.::
Human   686 GDSFRMKLNTQEIFDDWARKVQQRNL------GVSGRIF-----TIESTRVRG-------RTGNV 732

  Fly   799 SQLHLNFSQVLFTLLKETKYLLALQATGSLSGDLFQLPEPLLTLYGHRDAYWERRIRLIKIGEFY 863
            .:|.:||...:.||.||.:.|..|.         |::|..::......:..:...|.||:....|
Human   733 LKLKVNFLPEIITLSKEVRNLKWLG---------FRVPLAIVNKAHQANQLYPFAISLIESVRTY 788

  Fly   864 NGIRSGECAAAELQLIRNDLASIDEHVEVACQQLTWRNYNDELVAGIFEQSRDLFARLQQSHGNL 928
                                       |..|:::..||....||||:.::.:.|.|
Human   789 ---------------------------ERTCEKVEERNTISLLVAGLKKEVQALIA--------- 817

  Fly   929 DAILASMRRWSREPLHQRSLYGRNLLDLRHQQDRVRLRLLQCDETKMLLNRLLIANFCLFFNYES 993
            :.|......:..:|..||  ....:.:.:.:.|    .||..:|...|..|.|  ..|:   |:.
Human   818 EGIALVWESYKLDPYVQR--LAETVFNFQEKVD----DLLIIEEKIDLEVRSL--ETCM---YDH 871

  Fly   994 QEF-QLYSRDLSVQEFIREFPEEQRRQYNKYLASVDELICREVREAMRISLEYLYKEMTATATAT 1057
            :.| ::.:|   ||:.:.:.   ....|:.....|::| ..|:...:.:.|:
Human   872 KTFSEILNR---VQKAVDDL---NLHSYSNLPIWVNKL-DMEIERILGVRLQ------------- 916

  Fly  1058 TTPTAPPVDPGCSAGMARLVLQQITTPQATSTAGAGASGAPPTANDAPLFEVKLELTETEIRFSP 1122
                         ||:.  ...|:...||...|                 ||.::....::...|
Human   917 -------------AGLR--AWTQVLLGQAEDKA-----------------EVDMDTDAPQVSHKP 949

  Fly  1123 AFDASVENNFQQIVEQLLLDIKQTCDCMPRIVADNAPSEDDEDDDTATVDYEQELRWEPREDRAQ 1187
            ..:..::|    :|.:|.:        ..:::..|.|.|                  |.|....|
Human   950 GGEPKIKN----VVHELRI--------TNQVIYLNPPIE------------------ECRYKLYQ 984

  Fly  1188 ELQERKKKDLELEQEQGDPKPQAVQFNLLAAAKAYSQKMECTADGLEMLERAIRDALADTVAAAS 1252
            |:...|...|.|.:.|.......|.:.|....|.|...:....||...||.:. .|:...|:...
Human   985 EMFAWKMVVLSLPRIQSQRYQVGVHYELTEEEKFYRNALTRMPDGPVALEESY-SAVMGIVSEVE 1048

  Fly  1253 AYAAKFQAYAFLWTQQSSEV-------------LAACMQTAREQTHHVSAGGYAIMETFKKE--- 1301
            .|...:..|..||..|:..:             |...::.||        |.:...|| |||
Human  1049 QYVKVWLQYQCLWDMQAENIYNRLGEDLNKWQALLVQIRKAR--------GTFDNAET-KKEFGP 1104

  Fly  1302 -IENYNEVHDAIDQCENRECINGWLALDIKPLKYGLLNLACKWSHMCKKWLLRYVQ---GTLKEL 1362
             :.:|.:|...::                  |||.      .|.   |:.|.::.|   ..:.|.
Human  1105 VVIDYGKVQSKVN------------------LKYD------SWH---KEVLSKFGQMLGSNMTEF 1142

  Fly  1363 NAFIARGFETLQLH----IARQDFATLLR-VLAIMSEIREREPYADNVFKPLKEI------MGLL 1416
            ::.|::..:.|:.|    .:..|..|.:. |.::..:|::.|          |::      ..||
Human  1143 HSQISKSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQFE----------KQVELYRNGQRLL 1197

  Fly  1417 KTYNVEFEPQLLRGIEQLPQQW------QQLKHSSTVKQEALQDTRFHQ-----QQRVTALI--- 1467
            :....:|.|..|. |:.:..:|      .:.|.|:..:|.|....:..|     :.|.|.|:
Human  1198 EKQRFQFPPSWLY-IDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKIVQEDRAVESRTTDLLTDW 1261

  Fly  1468 --------------GLHTCHLQHYARQFQKMPFFRVPCPQVYDVCDEVYLRLHRFRRQQRLYTRW 1518
                          .|..  |..|..:|.::...|..|.:..:..:
Human  1262 EKTKPVTGNLRPEEALQA--LTIYEGKFGRLKDDREKCAKAKEALE------------------- 1305

  Fly  1519 ARLLD--IQPPDPATLQFCEVELRRVKQLWDFVRVIESCIVAWHATPWLLIDTDDMEHECKKFTR 1581
              |.|  :.......:|....||:.:|.:|..:..:...|......||:.:....:.........
Human  1306 --LTDTGLLSGSEERVQVALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQPRKLRQNLDALLN 1368

  Fly  1582 DLRTLDKCIREWAPYVHIVGVLRELVASLRAITELQNPAITERHWMELMQLTKLSYKCNKSTRLA 1646
            .|::....:|::|.|..:..:|:..:.....:.||::.|:.:|||.:||:...:::..::.| |.
Human  1369 QLKSFPARLRQYASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLMKRLHVNWVVSELT-LG 1432

  Fly  1647 QLLTLQLQHHEEDIKNTVDRAIKEMTVTKVLDEIKATWAHLEFELEQHHTRPHIQLLKVSEELIE 1711
            |:..:.||.:|..:|:.:..|..||.:.:.|.:|:..|...|.:|..:..:  .:|::..::|..
Human  1433 QIWDVDLQKNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNK--CRLIRGWDDLFN 1495

  Fly  1712 TLDDNQMQLQNISTSKHIEYLLDKLTHWQKVLGGIDTLIVNWFEVQRKWIYLECIFIGSADIRAQ 1776
            .:.::...:..:..|.:.:...:....|:..|..|..|...|.:|||:|:|||.||.|||||:..
Human  1496 KVKEHINSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGIFTGSADIKHL 1560

  Fly  1777 LPADAANFERIDEDFTALLAKVQEVRVVMQVVLRHDDVLAQLLQLQHRLAVCEKALNDYLETKRL 1841
            ||.:...|:.|..:|.||:.||.:..:||. ||....|...|.:|...|...:|||.:|||.:|.
Human  1561 LPVETQRFQSISTEFLALMKKVSKSPLVMD-VLNIQGVQRSLERLADLLGKIQKALGEYLERERS 1624

  Fly  1842 AFPRFYFISAADLLDILSNGNNPQVIDRHLIKLFDSILRLQYETNTPNALGMHSKENDEYVPFVS 1906
            :||||||:...|||:|:.|..|...:.:|..|:|..:..:....:....||:.|:|.:|    |.
Human  1625 SFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILNEDNSVVLGISSREGEE----VM 1685

  Fly  1907 FDPDQPAFIVCGGRVELWLRAIIQQMRSTLHELFRRA---LRVFGE----KPRE--LWLYDWPAQ 1962
            |  ..|..|....::..||..:.::||.||.:|...:   :.:||:    .|..  .|:..:.||
Human  1686 F--KTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNTYITWIDKYQAQ 1748

  Fly  1963 VALCCSQISWTADVNRSFGCMEEGYEGVMKELH---KRQIAQLNALINLLLGELSPGDRQKIMTI 2024
            :.:..:||:|:.:|..:...|..|  |....||   ......||.|.:.:|.|..|..|:|:..:
Human  1749 LVVLSAQIAWSENVETALSSMGGG--GDAAPLHSVLSNVEVTLNVLADSVLMEQPPLRRRKLEHL 1811

  Fly  2025 CTIDVHSRDVVGKIIASKVDNSLAFQWQSQLRHRWDDDQAGSSSGRASTAISCGGGDEDCFANIC 2089
            .|..||.|||...:|.||:||:.:|:|.||:|..:|..|....              :.....:.
Human  1812 ITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVL--------------QQLSIQMA 1862

  Fly  2090 DAEFRYAYEYLGNTSRLVITPLTDRCYITLTQSLRLRLAGATAGPAGTGKTETTKDLGRALGVMV 2154
            :|:|.|.:||||...:||.||||||||:|:||:|..||.|:..|||||||||:.|.||..||..|
Human  1863 NAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALGHQLGRFV 1927

  Fly  2155 YVFNCSEQMDYKSCGNIYKGLAQTGAWGCFDEFNRICVEVLSVVAVQVKTIQEAIKMH------K 2213
            .||||.|..|:::.|.|:.||.|.|||||||||||:...:||.|:.||:.||||::.|      |
Human  1928 LVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQEALREHSNPNYDK 1992

  Fly  2214 TQ----FIFMGERISLEPSVGIFITMNPGYAGRTELPENLKTLFRPCAMIVPDFALICEIMLMAE 2274
            |.    ...:.:::.:.|.:.||||||||||||:.||:|||.|||..||..||..||.::||.::
Human  1993 TSAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLAMTKPDRQLIAQVMLYSQ 2057

  Fly  2275 GFQDARLLARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGTLKRD---------------- 2323
            ||:.|.:||.|.:..:.||.|.||.|.|||:||||:|||||.||.:||:
Human  2058 GFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSAGNVKRERIQKIKREKEERGEAV 2122

  Fly  2324 -----DHSRPEDQVLMRALRDFNIPKIVTEDVPIFMGLIGDLFPALDVPRKRVFEFEKTIRRAVN 2383
                 ..:.||.::|::::.:..:||:|.||:|:...|:.|:||.:...|..:....:.:::...
Human  2123 DEGEIAENLPEQEILIQSVCETMVPKLVAEDIPLLFSLLSDVFPGVQYHRGEMTALREELKKVCQ 2187

  Fly  2384 EIKLQPEEG------FLMKVVQLQELLDVRHSVFIVGNAGTGKTKIWQT-LRETYRIQKLKPVCH 2441
            |:.|...:|      ::.||:||.::..:.|.:.:||.:|:||:..|:. |:...|::.::.|.|
Human  2188 EMYLTYGDGEEVGGMWVEKVLQLYQITQINHGLMMVGPSGSGKSMAWRVLLKALERLEGVEGVAH 2252

  Fly  2442 VLNPKALSNDELFGIVNPTTREWKDGLFSSIMREQANMPPG---NPKWIVLDGDIDPMWIESLNT 2503
            :::|||:|.|.|:|.::|.||||.||||:.::|:..:...|   ..:|||.|||:||.|:|:||:
Human  2253 IIDPKAISKDHLYGTLDPNTREWTDGLFTHVLRKIIDSVRGELQKRQWIVFDGDVDPEWVENLNS 2317

  Fly  2504 LMDDNKILTLASNERISLKREMRLLFEVGHLKAATPATVSRAGILYINPQDLGWSPYVSSWLETR 2568
            ::||||:|||.:.||:||...:|::|||..||.||.|||||.|:::.:...|.
Human  2318 VLDDNKLLTLPNGERLSLPPNVRIMFEVQDLKYATLATVSRCGMVWFSEDVLS------------ 2370

  Fly  2569 VDMIERGILNALFEKYFPCLMQRQRDFRRITPITDMAMIQMTCHLLECLLDSDEGNADGRGRGSA 2633
                                             |||........|....||..|..|..|.:|..
Human  2371 ---------------------------------TDMIFNNFLARLRSIPLDEGEDEAQRRRKGKE 2402

  Fly  2634 TGG--AANP-----------------------HSLHHG-ELSH---------------------- 2650
            ..|  ||:|                       .:|.|. :|.|
Human  2403 DEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFQLEHIMDLTRLRCLGSLFSMLHQACR 2467

  Fly  2651 ----------------EAMVMALETIFVYATVWSFGSALSQDVIIDWHREFHKWWIGEFKDIKLP 2699
                            |.:...::...|||.:||    ||.|..:....|..: :|.....:.||
Human  2468 NVAQYNANHPDFPMQIEQLERYIQRYLVYAILWS----LSGDSRLKMRAELGE-YIRRITTVPLP 2527

  Fly  2700 SQGT--VFDYQLNVQTLKFQPWSELAAHQSLEGQIDSET---PLQNVLISTAETIRLAYFLKLLI 2759
            :...  :.||::::.. ::.||      |:...||:.||   ...:|::.|.:|:|....|...:
Human  2528 TAPNIPIIDYEVSISG-EWSPW------QAKVPQIEVETHKVAAPDVVVPTLDTVRHEALLYTWL 2585

  Fly  2760 DRNLACMLVGNSGCGKG-AIFRQLFGQYANDQELLEVAVSAATAGDSSHQQQSGNPAGAVVVRRK 2823
            ..:...:|.|..|.||. .:|..|  :...|.|::.:..|:||
Human  2586 AEHKPLVLCGPPGSGKTMTLFSAL--RALPDMEVVGLNFSSAT---------------------- 2626

  Fly  2824 ASSSATPLLTTVQATHFNFYTSSEIFQKMLDRPLEKK---SGRCYAPSGPKRRLIYFVNDLNMPE 2885
                 ||                |:..|..|...|.:   :|...||....:.|:.|.:::|:|:
Human  2627 -----TP----------------ELLLKTFDHYCEYRRTPNGVVLAPVQLGKWLVLFCDEINLPD 2670

  Fly  2886 VDAYGTVQPHTIMRQFMDYRQWY---DRQRLQLKDIRHCQFAACMNPTA--GSFTIDPRLQRHFC 2945
            :|.|||.:..:.:||.:::..:|   |:..::|:.|   ||....||..  |...:..|..||..
Human  2671 MDKYGTQRVISFIRQMVEHGGFYRTSDQTWVKLERI---QFVGACNPPTDPGRKPLSHRFLRHVP 2732

  Fly  2946 VFSVAPPGEDTLHHIYGSILSSHLE-SPSQGFTKEIRSIGSLLVRVGIALHRRVEYAFLPTALKF 3009
            |..|..||..:|..|||:...:.|. .||      :|:....|....:..:...:..|.... :.
Human  2733 VVYVDYPGPASLTQIYGTFNRAMLRLIPS------LRTYAEPLTAAMVEFYTMSQERFTQDT-QP 2790

  Fly  3010 HYLFNLRDLT----GIYQGLMNSVGAPASAGGGGASGFGGTICSRPSE------LMRLYVHEAFR 3064
            ||:::.|::|    ||::.|                        ||.|      |:|::.|||.|
Human  2791 HYIYSPREMTRWVRGIFEAL------------------------RPLETLPVEGLIRIWAHEALR 2831

  Fly  3065 VYHDRLVDPYDIKSFKSSIRDIFKKDFEDFDEDFVFAEPLIYSHFAQSLVDQKYMPLKSWDSLYQ 3129
            ::.||||:..:.:....:|..:..|.|.:.|.:...:.|::||::    :.:.|:|:...:....
Human  2832 LFQDRLVEDEERRWTDENIDTVALKHFPNIDREKAMSRPILYSNW----LSKDYIPVDQEELRDY 2892

  Fly  3130 LLIEAQASYNEVVGYMNLVLFEDAMIHVCRINRILESPRGNALLIGVGGSGKQTLARLAAFISSL 3194
            :....:..|.|.:. :.||||.:.:.||.||:||...|:|:.|||||.|:||.||:|..|:::.|
Human  2893 VKARLKVFYEEELD-VPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGL 2956

  Fly  3195 NVSQIQIKRGFGLLDMREEIGNLYMKVGLKNLASVFLISDAQIPDESILMLINDLLASGEIPELF 3259
            :|.||::.|.:...|..|::..:..:.|.||....|::.::.:.|...|..:|.|||:||:|.||
Human  2957 SVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVLDSGFLERMNTLLANGEVPGLF 3021

  Fly  3260 NDDQLDTITNGIRNEVKQSG-TLDTKENCWRYFVEKVRRLLKVVLCFSPVGQTLRVRARKFPAII 3323
            ..|:..|:....:...::.| .||:.|..:::|..:|.|.|.||...:|..:.|:.||...||:.
Human  3022 EGDEYATLMTQCKEGAQKEGLMLDSHEELYKWFTSQVIRNLHVVFTMNPSSEGLKDRAATSPALF 3086

  Fly  3324 SRTAIDWFHEWPKSALESVSQKFLNEIN----GILEPALVPPI----------------GCFMAY 3368
            :|..::||.:|...||..|.::|.::::    ..:.|..:|.:                .|  .:
Human  3087 NRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNYIVPDYMPVVYDKLPQPPSHREAIVNSC--VF 3149

  Fly  3369 VHGTVNQISRIYLQNEKRYNYTTPKTFLEYIFLYRKLLVDKNGEFAERIARLQSGMSKLAECARQ 3433
            ||.|::|.:....:...|....||:.:|::|..|..|..:|..|..|:...|..|:.|:.|...|
Human  3150 VHQTLHQANARLAKRGGRTMAITPRHYLDFINHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQ 3214

  Fly  3434 VDTLKHQLAIQEVQLAAKNAAA-DKLIVIVSAESEKVKRERYIASEEEKRVRIIEEDVSIKTKMC 3497
            |:.|:..|.|:..:|..||||| |||..:|. :.::.::::.::.|.::::...:|.::.|....
Human  3215 VEELRRDLRIKSQELEVKNAAANDKLKKMVK-DQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSV 3278

  Fly  3498 EEDLRQAEPALVAAQAALNTLNKNNLTELKSFGSPPKAVVNVCAAVMVLLASNGKIPRDRSWKAS 3562
            :|||.:.|||::.||.|:.::.|.:|.|::|..:||.||.....::.:||   |:...|  ||..
Human  3279 KEDLDKVEPAVIEAQNAVKSIKKQHLVEVRSMANPPAAVKLALESICLLL---GESTTD--WKQI 3338

  Fly  3563 KLMMVRVDQFLNDLLNYNKDNIHPNIIETLQE-YLKDPEFNPDKVVQKSVAAAGLCAWVINLHRY 3626
            :.:::| :.|:..::|::.:.|...|.|.::: |:.:|.:|.:.|.:.|:|...:..|.|....|
Human  3339 RSIIMR-ENFIPTIVNFSAEEISDAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNY 3402

  Fly  3627 HQVFLIVGPKQQALQDSHQELLEARERLQYLKAKINNLEAKLAEIQAEFENAVGEKQRCQREADK 3691
            ..:...|.|.:..||....:..:.:::...::..|.:|||.:|..:.|:...:.|.|..:.:...
Human  3403 ADMLKRVEPLRNELQKLEDDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAA 3467

  Fly  3692 TAFTIDLAHRLVNGLANENVRWKESVQSLLAKIGTLPGDILLISSFLSYVGCFTRRYREEL---- 3752
            ....::.:..|:..|:.|..||:::.::...::.|:.||.||.::|::|.|.|.::.|:.|
Human  3468 VEAKVNRSTALLKSLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTW 3532

  Fly  3753 QHKMWLPN--FRKIDPHIPHTEGVDTLALFSDDAQIAAWNNEGLPMDRMSTENATILQYSTRWPL 3815
            .|.:...|  ||        |:...|..|.:.|.:: .|....||.|.:.||||.:|:...|:||
Human  3533 SHHLQQANIQFR--------TDIARTEYLSNADERL-RWQASSLPADDLCTENAIMLKRFNRYPL 3588

  Fly  3816 MIDPQLQGIKWIKNRFGTDLVVLR--LRQKGFLEALEKSISQGDTVLIEQIEESMDTVLEPLLSR 3878
            :|||..|..::|.|.: .|..:.|  .....|.:.||.::..|:.:|::.: ||.|.||.|:|:|
Human  3589 IIDPSGQATEFIMNEY-KDRKITRTSFLDDAFRKNLESALRFGNPLLVQDV-ESYDPVLNPVLNR 3651

  Fly  3879 ALIKKGR--YLRIGDKEIEFHASFRLILHTKMANPHYKPEMQAQTTLINFTVTPDGLEEQLLAEV 3941
            .:.:.|.  .:.:||::|:...||.:.|.|:.....:.|::.::.|.:|||||...|:.|.|.||
Human  3652 EVRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEV 3716

  Fly  3942 VKIERPDLEQMKTEVTVQQNKFKISLKALEDELLARLASSGENVLDDHALVINLENTKRTVDEIE 4006
            :|.||||:::.::::...|.:|::.|:.||..||..|......:|||..::..|||.||...|:.
Human  3717 LKAERPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEVT 3781

  Fly  4007 AKVREARVTTLQIDDTRNIYRSAAKRAAILYFVLTDLSRINPIYKFSLKSFMNVFRQAIAMAAES 4071
            .||.|..:...:::.....|...:...:.:||.:..|.:|:.:|::||:.|::::...:......
Human  3782 RKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLDIYHNVLYENPNL 3846

  Fly  4072 K---NYEKRVLHLVESITLQTYRYTLRGLFEADKLTFTSHMTLRILIAAEQV--AKDETDFLLRF 4131
            |   ::.:|:..:.:.:....:....||:...|      |:|..:|:|..::  ...|..:...|
Human  3847 KGVTDHTQRLSIITKDLFQVAFNRVARGMLHQD------HITFAMLLARIKLKGTVGEPTYDAEF 3905

  Fly  4132 PH-----------------DPTTLSPLDFVGR-SAWGGIKSL---TLIEHFYGIDKDMENYTKRW 4175
            .|                 ...|:...:.|.| |.....|.|   ...:..:||          |
Human  3906 QHFLRGNEIVLSAGSTPRIQGLTVEQAEAVVRLSCLPAFKDLIAKVQADEQFGI----------W 3960

  Fly  4176 RKFMASDTPEREQFPGEWKHRTP-------LQKLCIIRSLRPDRMTYAMRQFVEQTMGRSYAEIQ 4233
               :.|.:|| :..|..|...||       :.:|.:|::.||||:......||...:|.|:..|.
Human  3961 ---LDSSSPE-QTVPYLWSEETPATPIGQAIHRLLLIQAFRPDRLLAMAHMFVSTNLGESFMSIM 4021

  Fly  4234 TPPFG---AIFQELNAATPAFFILSPGVDPIRDVERYGQRQGFHSESDTLVNISLGQGQEL-LAE 4294
            ..|..   .:..|:...||......||.|....||.....|     :..:.:|::|..:.. .|:
Human  4022 EQPLDLTHIVGTEVKPNTPVLMCSVPGYDASGHVEDLAAEQ-----NTQITSIAIGSAEGFNQAD 4081

  Fly  4295 QAIIGALESGQQWVILQNIHLVVNWLPTLEKLIERIVLQSESKGESNFRLFISAEPAPDPQYHVI 4359
            :||..|::|| :||:|:|:||...||..|||.:..:      :..:.||||::.|..|.     :
Human  4082 KAINTAVKSG-RWVMLKNVHLAPGWLMQLEKKLHSL------QPHACFRLFLTMEINPK-----V 4134

  Fly  4360 PQGILESSLKVVNEPPSGMAANLHKAWDNFSQDALETCTQEAEFKSILFALCYFHAVAGERRKFG 4424
            |..:|.:....|.|||.|:.||:.:.:.:.....:  |....|...:.|.|.:|||:..||.::.
Human  4135 PVNLLRAGRIFVFEPPPGVKANMLRTFSSIPVSRI--CKSPNERARLYFLLAWFHAIIQERLRYA 4197

  Fly  4425 PQGWNKVYPFNIGDLTISSNVLHNYLEGS---------NRIPWEDLRYLFGEIMYGGHITDDWDR 4480
            |.||:|.|.|...||..:.:.:..:|:.:         ::|||..|:.|..:.:|||.:.:::|:
Human  4198 PLGWSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEFDQ 4262

  Fly  4481 RLCQTYLEELLQQDLIDGDFELC------PGFPAPPNLDFEGYHSYITEMLPE-ESPLLYGLHPN 4538
            ||..|:||.|......|.:|:|.      .....|..:..|.:..:: |:||: ::|...||..|
Human  4263 RLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWV-ELLPDTQTPSWLGLPNN 4326

  Fly  4539 AEIGFLTTASEQLLRTIFELQPRESE--------------LSSHCGAPR-EELVKIMIDDFLDKL 4588
            ||...|||....::..:.::|..|.|              .|:..|.|. ...:.....::|..:
Human  4327 AERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTDSTSDGRPAWMRTLHTTASNWLHLI 4391

  Fly  4589 QDEFNLQALLNRVER-KTPFVVVALQECERMNALIREIKRSLRELMLGLRGELTITQEMERLDHA 4652
            ..  .|..|...||. |.|......:|.:....|::::::.|.:::....|:...|..:..|.:.
Human  4392 PQ--TLSHLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYLRTLINE 4454

  Fly  4653 IFYDHVPAAWARLAYPSMLGLQSWFADLLHRIKEL--------AGWLNDFKLPCAIWLGGLFNPQ 4709
            :....:|.:|:....|:.:.:..|.:|...|||:|        :|...:.| ...:.|||||.|:
Human  4455 LVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISLAAASGGAKELK-NIHVCLGGLFVPE 4518

  Fly  4710 SFLTAIMQESARKHDLPLDRMLISCDVTKKQKDDVTLPPMEGAFVHDLYMDGASWDCQLNSIVAL 4774
            :::||..|..|:.:...|:.:.:..:||..|  ..||...... |..|.:.||:  |..|.:..
Human  4519 AYITATRQYVAQANSWSLEELCLEVNVTTSQ--GATLDACSFG-VTGLKLQGAT--CNNNKLSL- 4577

  Fly  4775 RPKEMLCAMPVIYIKSIVQEKQELQ-RVYECPLYKTRSRGN-TYVWTFNLKTRERPSRWILGGVA 4837
             ...:..|:|:..::.:.|...|.: .|...|:|...:|.: .:...|.:.|:|.|..:...|||
Human  4578 -SNAISTALPLTQLRWVKQTNTEKKASVVTLPVYLNFTRADLIFTVDFEIATKEDPRSFYERGVA 4641

  Fly  4838 LL 4839
            :|
Human  4642 VL 4643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3339	NP_001036762.2	DHC_N1	276..903	CDD:285571	134/698 (19%)
		DHC_N2	1535..1944	CDD:285579	112/411 (27%)
		P-loop_NTPase	2095..2324	CDD:304359	128/259 (49%)
		P-loop_NTPase	2409..2544	CDD:304359	62/138 (45%)
		P-loop_NTPase	2731..3061	CDD:304359	78/352 (22%)
		P-loop_NTPase	3138..3406	CDD:304359	87/288 (30%)
		MT	3419..3759	CDD:289543	89/345 (26%)
		AAA_9	3789..4001	CDD:289547	73/215 (34%)
		Dynein_heavy	4142..4832	CDD:281078	184/746 (25%)
DYNC1H1	NP_001367.2	Stem. /evidence=ECO:0000250	53..1867		429/2083 (21%)
		DHC_N1	242..832	CDD:400611	140/736 (19%)
		Interaction with DYNC1I2. /evidence=ECO:0000250	448..703		47/271 (17%)
		Interaction with DYNC1LI2. /evidence=ECO:0000250	651..802		36/204 (18%)
		DYN1	1046..4329	CDD:227570	962/3579 (27%)
		AAA 1. /evidence=ECO:0000250	1868..2099		123/230 (53%)
		AAA 2. /evidence=ECO:0000250	2180..2452		92/316 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2390..2411		7/20 (35%)
		AAA 3. /evidence=ECO:0000250	2556..2805		68/303 (22%)
		AAA 4. /evidence=ECO:0000250	2899..3168		81/271 (30%)
		Stalk. /evidence=ECO:0000250	3189..3500		80/317 (25%)
		AAA 5. /evidence=ECO:0000250	3553..3782		77/231 (33%)
		AAA 6. /evidence=ECO:0000250	4005..4221		66/234 (28%)
		Dynein_C	4333..4644	CDD:408026	70/321 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710