DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hmu and PNPT1

DIOPT Version :9

Sequence 1:	NP_477159.1	Gene:	Hmu / 43294	FlyBaseID:	FBgn0015737	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_149100.2	Gene:	PNPT1 / 87178	HGNCID:	23166	Length:	783	Species:	Homo sapiens

Alignment Length:	309	Identity:	63/309 - (20%)
Similarity:	104/309 - (33%)	Gaps:	98/309 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 WTDSSSDFTIEDLVFASFANPSGRLFKYNRSKNVSEVLLDELAFANGLALSPNEDFIVVAETGAM 249
            |:.:.|.....||........||:|.:                ||:|.|:..:.|..|:..  |:
Human    39 WSSAGSRAVAVDLGNRKLEISSGKLAR----------------FADGSAVVQSGDTAVMVT--AV 85

  Fly   250 RLTK------------YHLKGAKAGQSEVFVDGLPGLPDNLTPDAEGIWVPLVQSADSEHPNGFT 302
            ..||            |..|.|.||:          :|.|......|       ::|.|
Human    86 SKTKPSPSQFMPLVVDYRQKAAAAGR----------IPTNYLRREIG-------TSDKE------ 127

  Fly   303 LFTRFPSVRLFLARMLALFELPFRYLNSVYPNKFSQRFVHFVGHMESITVLAPKRTTVV----RV 363
            :.|.    |:....:..||...:.|...|..|..:      |..:....|||....:|.    .:
Human   128 ILTS----RIIDRSIRPLFPAGYFYDTQVLCNLLA------VDGVNEPDVLAINGASVALSLSDI 182

  Fly   364 DWNGNI----VGSLHG--------FDKSAATVSHVLEFQDFLFLGSPTNQYLARVKSPK------ 410
            .|||.:    :|.:.|        .:.|::|::.|:       .|:|.:|.:....|.:
Human   183 PWNGPVGAVRIGIIDGEYVVNPTRKEMSSSTLNLVV-------AGAPKSQIVMLEASAENILQQD 240

  Fly   411 ---AKQPTLKVRNVRVEG-EGLEASIGVPPSKATPKPKAAPSTTTPKPT 455
               |.:..:|.....::| :.|....||  :|.||:....||....|.|
Human   241 FCHAIKVGVKYTQQIIQGIQQLVKETGV--TKRTPQKLFTPSPEIVKYT 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmu	NP_477159.1	YvrE	61..>287	CDD:225921	24/113 (21%)
Hmu	NP_477159.1	Str_synth	173..258	CDD:304606	17/84 (20%)
PNPT1	NP_149100.2	PRK11824	49..752	CDD:236995	61/299 (20%)
		RNase_PH_PNPase_1	49..273	CDD:206768	55/283 (19%)
		PNPase	282..363	CDD:281688	2/6 (33%)
		RNase_PH_PNPase_2	366..596	CDD:206769
		KH-I	605..664	CDD:294072
		S1	679..750	CDD:197648
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1185
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900