DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hmu and AT3G51450

DIOPT Version :9

Sequence 1:	NP_477159.1	Gene:	Hmu / 43294	FlyBaseID:	FBgn0015737	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_190713.1	Gene:	AT3G51450 / 824308	AraportID:	AT3G51450	Length:	371	Species:	Arabidopsis thaliana

Alignment Length:	424	Identity:	114/424 - (26%)
Similarity:	192/424 - (45%)	Gaps:	83/424 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGLLYALRVRIMNFMIFFLLIILM-------PGLPPRTTFPFKDYIVTPPKDLKGALESNFHLEG 58
            |.:|::.|..|::.::..|:.|.:       |.:.|...|......:.|       |.::..|.|
plant     1 MPVLFSSRSLILSIIVPLLISIALYKLDTFDPAIVPSDAFTSSATSLPP-------LINDEFLTG 58

  Fly    59 AERLLEGRVYGPECLI--ARNNEIYTGIHGGEVIKLTSNHVTHVTKIGQPCEDIYEE---SRCGR 118
            ||.:..|.:..||.:.  ..:|.||||...|.|.::         |:.....|...|   :..||
plant    59 AEFIGVGLLNIPEDIAYHKESNLIYTGCVDGWVKRV---------KVADSVNDSVVEDWVNTGGR 114

  Fly   119 PLGLAFDTQGNNLIIADAYYGLWQVDLGTNKKTLLVSPAQELAGKSINRPAKIFNGVTVSKEGDV 183
            |||:||...| .:|:||.:.||..:. |..|||.|::  .|..|...    |:.:.|||:..|.:
plant   115 PLGIAFGIHG-EVIVADVHKGLLNIS-GDGKKTELLT--DEADGVKF----KLTDAVTVADNGVL 171

  Fly   184 YWTDSSSDFTIEDLVFASF-ANPSGRLFKYNRSKNVSEVLLDELAFANGLALSPNEDFIVVAETG 247
            |:||:|..:|:..|..... ..|.|||..::.:..|::|||.:|.||||:.:||::..::..||.
plant   172 YFTDASYKYTLNQLSLDMLEGKPFGRLLSFDPTTRVTKVLLKDLYFANGITISPDQTHLIFCETP 236

  Fly   248 AMRLTKYHLKGAKAGQSEVFVDGLPGLPDNLTPDAEG-IWVPLVQSADSEHPNGFT----LFTRF 307
            ..|.:||::...:.   |||...|||.|||:..|.:| .|:.|        |:|.|    :..::
plant   237 MKRCSKYYISEERV---EVFTQSLPGYPDNIRYDGDGHYWIAL--------PSGVTTLWNISLKY 290

  Fly   308 PSVRLFLARMLALFELPFRYLNSVYPNKFSQRFVHFVGHMESITVLAPKRTTVVRVDWNGNIVGS 372
            |.:|. |..|:|.:.:...:                   ||:..||        :||.:||.:..
plant   291 PFLRK-LTAMVAKYGVDLMF-------------------MENAGVL--------QVDLDGNPIAY 327

  Fly   373 LHGFDKSAATVSHVLEFQDFLFLGSPTNQYLARV 406
            .|  |...:.::...:...:|:.||.:..::.|:
plant   328 YH--DPKLSHIATCDKIGKYLYCGSLSQSHILRL 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmu	NP_477159.1	YvrE	61..>287	CDD:225921	75/232 (32%)
Hmu	NP_477159.1	Str_synth	173..258	CDD:304606	30/85 (35%)
AT3G51450	NP_190713.1	NHL	<52..130	CDD:302697	26/87 (30%)
		NHL repeat	69..109	CDD:271320	12/48 (25%)
		NHL	92..>226	CDD:302697	48/150 (32%)
		NHL repeat	115..153	CDD:271320	17/41 (41%)
		NHL repeat	160..213	CDD:271320	17/52 (33%)
		Str_synth	161..248	CDD:281131	30/86 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	63	1.000	Domainoid score	I3710
eggNOG	1	0.900	-	-		E1_COG1185
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I1870
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D757814at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101875
Panther	1	1.100	-	-	O	PTHR10426
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.830