DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hmu and YLS2

DIOPT Version :9

Sequence 1:	NP_477159.1	Gene:	Hmu / 43294	FlyBaseID:	FBgn0015737	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_566951.1	Gene:	YLS2 / 824306	AraportID:	AT3G51430	Length:	371	Species:	Arabidopsis thaliana

Alignment Length:	431	Identity:	121/431 - (28%)
Similarity:	204/431 - (47%)	Gaps:	80/431 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGLLYALRVRIMNFMIFFLLIILMP--GLPPRTTF-----PFKDYIVT----PPKDLKGALESNF 54
            |.:.|:.|     |:.||.::.|:.  .|....||     |.:.|..:    ||      |.|:.
plant     1 MPMFYSSR-----FLFFFTIVPLLVSIALYQLDTFDPAPVPSEAYASSTTSIPP------LISDK 54

  Fly    55 HLEGAERLLEGRVYGPECLIAR--NNEIYTGIHGGEVIKLTSNHVTHVTKIGQPCEDIYEESRCG 117
            :|.|||.:..|.:..||.:...  :|.||||...|.|.:::    .|.:......||.....  |
plant    55 YLTGAEFIGVGLLDKPEDIAYHQDSNLIYTGCIDGWVKRVS----VHDSANDSVVEDWVNTG--G 113

  Fly   118 RPLGLAFDTQGNNLIIADAYYGLWQVDLGTNKKTLLVSPAQELAGKSINRPAKIFNGVTVSKEGD 182
            ||||:||...| .:|:||||.||..:. |..|||.|::...|  |...    |:.:.|.|:..|.
plant   114 RPLGIAFGVHG-EVIVADAYKGLLNIS-GDGKKTELLTDQAE--GVKF----KLTDVVAVADNGV 170

  Fly   183 VYWTDSSSDFTIEDLVFASF-ANPSGRLFKYNRSKNVSEVLLDELAFANGLALSPNEDFIVVAET 246
            :|:||:|..:|:..:.|... ..|.|||..::.:..|:.|||.:|.||||:::||::..::..||
plant   171 LYFTDASYKYTLHQVKFDILEGKPHGRLMSFDPTTRVTRVLLKDLYFANGVSMSPDQTHLIFCET 235

  Fly   247 GAMRLTKYHLKGAKAGQSEVFVDGLPGLPDNLTPDAEG-IWVPLVQSADSEHPNGFTLFTRFPSV 310
            ...|.:||::...:.   |||:.||||.|||:..|.:| .|:.:|..|.:.    :.|..::|
plant   236 PMRRCSKYYINEERV---EVFIQGLPGYPDNIRYDGDGHYWIAMVSGASTL----WRLSMKYP-- 291

  Fly   311 RLFLARMLALFELPFRYLNSVYPNKFSQRFVHFVGHMESITVLAPKRTTVVRVDWNGNIVGSLHG 375
              ||.::.|   :..:|                     .:.::..|...|::||.:||.:...|
plant   292 --FLRKITA---IAAKY---------------------GVELMFMKNAGVLQVDLDGNPIAYYH- 329

  Fly   376 FDKSAATVSHVLEFQDFLFLGSPTNQYLAR---VKSPKAKQ 413
             |:..:.::..::..::|:.|:..:.|:.|   :|.|..|:
plant   330 -DQRLSHITTGIKIGNYLYCGNILHSYIIRLDLLKYPAQKK 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmu	NP_477159.1	YvrE	61..>287	CDD:225921	77/229 (34%)
Hmu	NP_477159.1	Str_synth	173..258	CDD:304606	29/85 (34%)
YLS2	NP_566951.1	YvrE	70..299	CDD:225921	84/256 (33%)
YLS2	NP_566951.1	Str_synth	161..248	CDD:281131	29/86 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	63	1.000	Domainoid score	I3710
eggNOG	1	0.900	-	-		E1_COG1185
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I1870
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D757814at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3471
orthoMCL	1	0.900	-	-		OOG6_101875
Panther	1	1.100	-	-	O	PTHR10426
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.830