DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hmu and APMAP

DIOPT Version :9

Sequence 1:	NP_477159.1	Gene:	Hmu / 43294	FlyBaseID:	FBgn0015737	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_065392.1	Gene:	APMAP / 57136	HGNCID:	13238	Length:	416	Species:	Homo sapiens

Alignment Length:	411	Identity:	134/411 - (32%)
Similarity:	210/411 - (51%)	Gaps:	56/411 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FMIFFLLIILMPGLP----------PRTTFP--FKDYIVTPPKDLKGALESNFHLEGAERLLEGR 66
            |.:.||::.:...:|          |....|  ||:    ||. |.|.|..|..|..||||.|.:
Human    39 FRVTFLMLAVSLTVPLLGAMMLLESPIDPQPLSFKE----PPL-LLGVLHPNTKLRQAERLFENQ 98

  Fly    67 VYGPECLIARNNEIYTGIHGGEVIKLTSNHVTHVTKIGQ-PCEDIYEESRCGRPLGLAFDTQGNN 130
            :.|||.:....:.::||...|.|:||.:..:..:.:.|. ||:...:|..||||||:.....| .
Human    99 LVGPESIAHIGDVMFTGTADGRVVKLENGEIETIARFGSGPCKTRDDEPVCGRPLGIRAGPNG-T 162

  Fly   131 LIIADAYYGLWQVDLGTNKKTLLVSPAQELAGKSINRPAKIFNGVTVSKEG-DVYWTDSSSDFTI 194
            |.:||||.||::|:....:..||:|....:.||:::    ..|.:||:::| .:|:|||||.:..
Human   163 LFVADAYKGLFEVNPWKREVKLLLSSETPIEGKNMS----FVNDLTVTQDGRKIYFTDSSSKWQR 223

  Fly   195 ED-LVFASFANPSGRLFKYNRSKNVSEVLLDELAFANGLALSPNEDFIVVAETGAMRLTKYHLKG 258
            .| |:........|||.:|:......:||||:|.|.||:.|||.|||::||||...|:.:.::.|
Human   224 RDYLLLVMEGTDDGRLLEYDTVTREVKVLLDQLRFPNGVQLSPAEDFVLVAETTMARIRRVYVSG 288

  Fly   259 AKAGQSEVFVDGLPGLPDNLTPDAE-GIWVPLVQSADSEHPN-GFTLFTRFPSVRLFLARMLALF 321
            ...|.:::||:.:||.|||:.|.:. |.||.:    .:..|| ||::.. |.|.|.::.||  :|
Human   289 LMKGGADLFVENMPGFPDNIRPSSSGGYWVGM----STIRPNPGFSMLD-FLSERPWIKRM--IF 346

  Fly   322 ELPFRYLNSVYPNKFSQRFVHFVGHMESITVLAPKRTTVVRVDWNGNIVGSLHGFDKSAAT-VSH 385
            :|            |||         |::....|:.:.|:.:..:|....|||..|...|| :|.
Human   347 KL------------FSQ---------ETVMKFVPRYSLVLELSDSGAFRRSLHDPDGLVATYISE 390

  Fly   386 VLEFQDFLFLGSPTNQYLARV 406
            |.|....|:|||..:.:|.|:
Human   391 VHEHDGHLYLGSFRSPFLCRL 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmu	NP_477159.1	YvrE	61..>287	CDD:225921	82/229 (36%)
Hmu	NP_477159.1	Str_synth	173..258	CDD:304606	35/86 (41%)
APMAP	NP_065392.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		YvrE	73..>320	CDD:225921	94/256 (37%)
		NHL	96..>284	CDD:302697	69/192 (36%)
		NHL repeat	102..137	CDD:271320	8/34 (24%)
		NHL repeat	152..193	CDD:271320	15/41 (37%)
		NHL repeat	200..252	CDD:271320	16/51 (31%)
		Str_synth	201..288	CDD:304606	35/86 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160328
Domainoid	1	1.000	77	1.000	Domainoid score	I8871
eggNOG	1	0.900	-	-		E1_COG1185
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41380
Inparanoid	1	1.050	174	1.000	Inparanoid score	I4069
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48544
OrthoDB	1	1.010	-	-		D336287at33208
OrthoFinder	1	1.000	-	-		FOG0001350
OrthoInspector	1	1.000	-	-		otm40608
orthoMCL	1	0.900	-	-		OOG6_101875
Panther	1	1.100	-	-	O	PTHR10426
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3581
SonicParanoid	1	1.000	-	-		X608
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800