DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bigmax and MLX

DIOPT Version :9

Sequence 1:	NP_651556.2	Gene:	bigmax / 43293	FlyBaseID:	FBgn0039509	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_733752.1	Gene:	MLX / 6945	HGNCID:	11645	Length:	298	Species:	Homo sapiens

Alignment Length:	210	Identity:	102/210 - (48%)
Similarity:	142/210 - (67%)	Gaps:	10/210 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SRCSSAGSTHTPNSSAHNSDDDDDSGDARHSAAANSTLSYKERRREAHTQAEQKRRDAIKKGYDS 93
            ||.:|.|||..  ||..|:||:|..   .|..|...  |||:|||.||||||||||||||:|||.
Human    94 SRANSIGSTSA--SSVPNTDDEDSD---YHQEAYKE--SYKDRRRRAHTQAEQKRRDAIKRGYDD 151

  Fly    94 LQELVPRCQPNDSS--GYKLSKALILQKSIEYIGYLNQQKLKQEDEGSALQKEVTALRIIKNGYE 156
            ||.:||.||..|.|  ..|||||::|||:|:||.:|:::|.|||:|.|.|:|:||||:|:|..||
Human   152 LQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYE 216

  Fly   157 NMLQHQQANPGPEEARLTDEAKFQVFQAIMEEMFETFQ-HIPMENFKQLTTGIIPWLEEHCKPHI 220
            .:::..|.||...|.:::|:.||.|||.||:.:|::|. .|.:.:|::|:..:..|:||||||..
Human   217 QIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCKPQT 281

  Fly   221 LRNILSRTLQQMAQE 235
            ||.|:...|.|:..:
Human   282 LREIVIGVLHQLKNQ 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bigmax	NP_651556.2	HLH	69..130	CDD:238036	41/62 (66%)
MLX	NP_733752.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..145		31/57 (54%)
		HLH	130..188	CDD:306515	38/57 (67%)
		Leucine-zipper	140..160		14/19 (74%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141622
Domainoid	1	1.000	96	1.000	Domainoid score	I7377
eggNOG	1	0.900	-	-		E1_KOG1319
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7969
Inparanoid	1	1.050	189	1.000	Inparanoid score	I3909
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45474
OrthoDB	1	1.010	-	-		D1234389at2759
OrthoFinder	1	1.000	-	-		FOG0007499
OrthoInspector	1	1.000	-	-		oto89061
orthoMCL	1	0.900	-	-		OOG6_106895
Panther	1	1.100	-	-	LDO	PTHR15741
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5340
SonicParanoid	1	1.000	-	-		X6384
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800