DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bigmax and Mlx

DIOPT Version :9

Sequence 1:	NP_651556.2	Gene:	bigmax / 43293	FlyBaseID:	FBgn0039509	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_035680.3	Gene:	Mlx / 21428	MGIID:	108398	Length:	298	Species:	Mus musculus

Alignment Length:	223	Identity:	102/223 - (45%)
Similarity:	147/223 - (65%)	Gaps:	10/223 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GMEHDQDHTSKHYSRCSSAGSTHTPNSSAHNSDDDDDSGDARHSAAANSTLSYKERRREAHTQAE 80
            |:..:..|.....||.:|.|||..  ||..|:||:|  .|.:..:...   |||:|||.||||||
Mouse    81 GLFVESTHKGSVVSRANSIGSTSA--SSVPNTDDED--SDYQQESYKE---SYKDRRRRAHTQAE 138

  Fly    81 QKRRDAIKKGYDSLQELVPRCQPNDSS--GYKLSKALILQKSIEYIGYLNQQKLKQEDEGSALQK 143
            ||||||||:|||.||.:||.||..|.|  ..|||||::|||:|:||.:|:::|.|||:|.|.|:|
Mouse   139 QKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRK 203

  Fly   144 EVTALRIIKNGYENMLQHQQANPGPEEARLTDEAKFQVFQAIMEEMFETFQ-HIPMENFKQLTTG 207
            :||||:|:|..||.:::..|.||...|.:::|:.||.|||.||:.:|::|. .|.:.:|::|:..
Mouse   204 DVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQELSAC 268

  Fly   208 IIPWLEEHCKPHILRNILSRTLQQMAQE 235
            :..|:||||:|..||.|:...|.|:..:
Mouse   269 VFSWIEEHCEPQTLREIVIGVLHQLKNQ 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bigmax	NP_651556.2	HLH	69..130	CDD:238036	41/62 (66%)
Mlx	NP_035680.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..119		11/24 (46%)
		HLH	130..188	CDD:278439	38/57 (67%)
		Leucine-zipper	194..214		12/19 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831569
Domainoid	1	1.000	94	1.000	Domainoid score	I7490
eggNOG	1	0.900	-	-		E1_KOG1319
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7969
Inparanoid	1	1.050	190	1.000	Inparanoid score	I3876
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45474
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007499
OrthoInspector	1	1.000	-	-		oto92628
orthoMCL	1	0.900	-	-		OOG6_106895
Panther	1	1.100	-	-	LDO	PTHR15741
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5340
SonicParanoid	1	1.000	-	-		X6384
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790