DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)mbt and scml4

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_001332433.4	Gene:	scml4 / 794170	ZFINID:	ZDB-GENE-041210-338	Length:	475	Species:	Danio rerio

Alignment Length:	545	Identity:	104/545 - (19%)
Similarity:	154/545 - (28%)	Gaps:	234/545 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   964 MHLEAEDLNDTGKICVATVTDILDERIRVHFDGWDD-------CYDLWVHITSPYIHPCGWHEGR 1021
            |.|...||.|:....:.:|..:...|:|:..|..||       ..||...:.|          ||
Zfish     1 MRLRGRDLEDSTVSWIPSVLGVQSVRLRLRLDRRDDRGRSLWQLVDLGEEVQS----------GR 55

  Fly  1022 -----------QQLIVPP----------DYQKSAFIWDDYISEVGGMAASKELFTP---RQPMEY 1062
                       |.|:..|          :.|....|...::....|....::...|   |.| ||
Zfish    56 RPRDRTPPTCSQSLMSIPAAPSVQSGGGEMQSPGVISPSFLPPASGKVPGRKRGRPPLKRHP-EY 119

  Fly  1063 QERMKLEVVDQRNPCLIRPATVVTRKG--------YRVQLHLDCWPTEYYFWLEDDSPDLHPIGW 1119
            |.|.         |..:.|..|..::|        .|:...|...|..     ....||:..|..
Zfish   120 QSRY---------PESLPPIKVPKKRGRKPGFKLKSRLMTPLAISPPS-----STPEPDMSSIPQ 170

  Fly  1120 CEATSHELETP---------------------------PGYL---QPKSVMPCDVEGC------- 1147
            ..||.....||                           |.:|   :|..|:...|:||
Zfish   171 DAATIPHSATPQVLTVCIYVNKQVNTGPNLDRQKVLQLPDHLGPARPSVVLQQAVQGCIDSAFQQ 235

  Fly  1148 --------RGFGNAK---RFNLNVHA---------------LRECC------------PYAP--- 1171
                    .|:|..|   .|:...|.               |::.|            |.||
Zfish   236 KAVFTLLTEGYGGEKISATFDGKQHLLSLPVVNSVGYVLRFLKKLCRSLLCENLFSDQPIAPSSS 300

  Fly  1172 ---------ENWRQWRSK-----------TVKPPRVAPENIRRGWAKKTKRACSEAKQAIKEDSQ 1216
                     |.....:||           :|:|.|.:.:....| |..:..|.|:.....:..|.
Zfish   301 PSSSSSFHMEKHSDGQSKSNSMVDDYHGDSVEPKRYSVDPSDFG-AMSSPYAASKPAYGFRSASA 364

  Fly  1217 ------QEIVYPKV-AEVVQAKRKTSPCEEKVVKKQKQMQKEEDAEQV-------PDERSLAIAR 1267
                  ::...|.. .|..::....||                ||.:|       |...|:....
Zfish   365 YSGGICRQAASPSTFPEGNRSAYSPSP----------------DAGEVKPPPSKDPSRWSVDEVV 413

  Fly  1268 SFVKDYGPQFL-PNYRLWQLNSAFKLDDVRTNPLHWTSWDVCEYIERALDSTDIAKVIFEQDIDG 1331
            .|:||..||.| |:..|::                                        :.:|||
Zfish   414 WFIKDADPQALGPHVELFR----------------------------------------KHEIDG 438

  Fly  1332 RALLMLGRKELDTYLKLKVGPAVKL 1356
            .|||:|....:..||.||:|||:||
Zfish   439 DALLLLKSDMIMKYLGLKLGPALKL 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723
		MBT	929..1028	CDD:214723	18/81 (22%)
		MBT	1038..1130	CDD:214723	20/102 (20%)
		SAM_PNT	1279..1366	CDD:280377	18/78 (23%)
scml4	XP_001332433.4	DUF3588	185..293	CDD:288954	14/107 (13%)
		SAM_Scm	401..472	CDD:188977	26/103 (25%)
		SAM	404..472	CDD:197735	26/100 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583959
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840