DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)mbt and SFMBT2

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001018049.1	Gene:	SFMBT2 / 57713	HGNCID:	20256	Length:	894	Species:	Homo sapiens

Alignment Length:	931	Identity:	194/931 - (20%)
Similarity:	299/931 - (32%)	Gaps:	362/931 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   763 QSTQKESKI---SRTQLEQTAGTA---PDLPQKRQTNYKPHKSLSAIQEQLQQRQKDKPRKPFRW 821
            :||...|.:   |.:.||:..|:|   .||..:..         |:::|           ..|.|
Human     2 ESTLSASNMQDPSSSPLEKCLGSANGNGDLDSEEG---------SSLEE-----------TGFNW 46

  Fly   822 SEYLKSKGKDVAAPIHLFLNPFPIS-PNCFEIGMKLEAIDPENCSLFCVCSIVEVRGYRLKLSFD 885
            .|||:..|.. ||| |.......|| .:.|:.|||||..:..|...:.|.:|:...|..|.|.:.
Human    47 GEYLEETGAS-AAP-HTSFKHVEISIQSNFQPGMKLEVANKNNPDTYWVATIITTCGQLLLLRYC 109

  Fly   886 GYSS--MYDFWVNADSQDIFPPGWCDETARVLQAPKDYNSERFSWSRYLVK--TGGKAAPRALF- 945
            ||..  ..|||.:....|:.|.|||.:..:||..|.....:...|:.:|::  ||.:.||..|.
Human   110 GYGEDRRADFWCDVVIADLHPVGWCTQNNKVLMPPDAIKEKYTDWTEFLIRDLTGSRTAPANLLE 174

  Fly   946 GHLNMQQQMDVRNGFAVGMHLEAEDLNDTGKICVATVTDILDERIRVHFDGWDD--CYDLWVHIT 1008
            |.|..:..:|:   ..||..:|.:|..:..:..:.:|.:.:..|:|:.:.|.:|  .||.|:...
Human   175 GPLRGKGPIDL---ITVGSLIELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEDTESYDQWLFYL 236

  Fly  1009 SPYIHPCGWHEGRQQLIVPPD-------------------------------------------- 1029
            ...:.|.||.:..:..:.||.
Human   237 DYRLRPVGWCQENKYRMDPPSEIYPLKMASEWKCTLEKSLIDAAKFPLPMEVFKDHADLRSHFFT 301

  Fly  1030 ----------------------------------------------------------------- 1029

Human   302 VGMKLETVNMCEPFYISPASVTKVFNNHFFQVTIDDLRPEPSKLSMLCHADSLGILPVQWCLKNG 366

  Fly  1030 --------YQKSAFIWDDYISEVGGMAASKELFTPRQ-PMEYQERMKLEVVDQRNPCLIRPATVV 1085
                    |....|.|.||..:.|...|....|.... ...:.:.||||.|:.|||..:..|:||
Human   367 VSLTPPKGYSGQDFDWADYHKQHGAQEAPPFCFRNTSFSRGFTKNMKLEAVNPRNPGELCVASVV 431

  Fly  1086 TRKGYRVQLHLDCWPTEYYFWLED-DSPDLHPIGWCEATSHELETPP----------GYLQPKSV 1139
            :.||..:.|||:...|.....:.| :|.|:.|:|||||.|:.|..|.          ..:||:..
Human   432 SVKGRLMWLHLEGLQTPVPEVIVDVESMDIFPVGWCEANSYPLTAPHKTVSQKKRKIAVVQPEKQ 496

  Fly  1140 MPCDV-------EGC-------RGFGNAKRFNLNVHALRECCPYAPENWRQWRSKTVKPPRVA-- 1188
            :|..|       :.|       .|..|.|          .|||....|.|.:....:...|:|
Human   497 LPPTVPVKKIPHDLCLFPHLDTTGTVNGK----------YCCPQLFINHRCFSGPYLNKGRIAEL 551

  Fly  1189 PENIRRG----------------------------------W--------AK---KTKRA----- 1203
            |:::..|                                  |        ||   ||.||
Human   552 PQSVGPGKCVLVLKEVLSMIINAAYKPGRVLRELQLVEDPHWNFQEETLKAKYRGKTYRAVVKIV 616

  Fly  1204 --------------------------------CSE--------------------AKQAIKEDSQ 1216
                                            |.|                    :|..|.| |.
Human   617 RTSDQVANFCRRVCAKLECCPNLFSPVLISENCPENCSIHTKTKYTYYYGKRKKISKPPIGE-SN 680

  Fly  1217 QEIVYPKVAE--------VVQAKRKTSPCEEKVVKKQKQMQKEEDAEQVPDERSLAIARSFVKD- 1272
            .:..:||.|.        .||.||::|..:  ......:..:||||:.:.|:.:.....|.::|
Human   681 PDSGHPKPARRRKRRKSIFVQKKRRSSAVD--FTAGSGEESEEEDADAMDDDTASEETGSELRDD 743

  Fly  1273 -------YGPQFLPNYRLWQLNSAFK-----------------------------------LDDV 1295
                   ..|...|. |...|.|..:                                   .:|.
Human   744 QTDTSSAEVPSARPR-RAVTLRSGSEPVRRPPPERTRRGRGAPAASSAEEGEKCPPTKPEGTEDT 807

  Fly  1296 R----------TNPLHWTSWDVCEYIERALDSTDIAKVIFEQDIDGRALLMLGRKELDTYLKLKV 1350
            :          :|||.||..||..:| :..|...:||:..||||||:|||:|....:...::||:
Human   808 KQEEEERLVLESNPLEWTVTDVVRFI-KLTDCAPLAKIFQEQDIDGQALLLLTLPTVQECMELKL 871

  Fly  1351 GPAVKLYSLILNLRIAVVCKF 1371
            |||:||...|..:::|...::
Human   872 GPAIKLCHQIERVKVAFYAQY 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	34/98 (35%)
		MBT	929..1028	CDD:214723	24/103 (23%)
		MBT	1038..1130	CDD:214723	33/93 (35%)
		SAM_PNT	1279..1366	CDD:280377	34/131 (26%)
SFMBT2	NP_001018049.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39		11/45 (24%)
		MBT 1	44..144		36/101 (36%)
		MBT	48..144	CDD:214723	34/97 (35%)
		MBT 2	152..256		25/106 (24%)
		MBT	156..256	CDD:214723	24/102 (24%)
		MBT 3	266..372		0/105 (0%)
		MBT	276..372	CDD:214723	0/95 (0%)
		MBT 4	380..477		35/96 (36%)
		MBT	384..477	CDD:214723	33/92 (36%)
		SLED	528..643	CDD:403384	15/114 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	672..813		25/144 (17%)
		SAM_Scm-like-4MBT1,2	810..894	CDD:188980	30/84 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149812
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840