DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)mbt and l3mbtl2

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_956326.1	Gene:	l3mbtl2 / 568473	ZFINID:	ZDB-GENE-030131-8713	Length:	805	Species:	Danio rerio

Alignment Length:	725	Identity:	161/725 - (22%)
Similarity:	268/725 - (36%)	Gaps:	215/725 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   686 NEFNFLQINERCQPRQGPAAYFERPLYDRPGRRPSACVHPLLYLCQRCNFHGPAADFLA--PHFC 748
            |:.||....:     .||.             :||:.|...:..|:.|...|....|.:  ..||
Zfish   142 NQHNFSDDGD-----NGPV-------------KPSSWVDDGIVACEMCGAVGSIDTFFSRTKRFC 188

  Fly   749 SVGCVRRSQKRRLPQSTQKESKISRTQLEQTAGTAPDLPQKRQTN-YKPHKSLSAIQEQLQQRQK 812
            |..|     .|....:::|.|.::|.|...:..::..|..|.||. .:|        :.::|.|:
Zfish   189 SASC-----SRSYSSNSKKSSILARLQGRPSKKSSHKLCPKTQTEVLRP--------KVIEQHQE 240

  Fly   813 DKP------RKPFRWSEYLKSKGKDVAAPIHLFLNPFPISPNCFE-----IGMKLEAIDPENC-- 864
            .:|      ...|.|..||:..|. :|||:..|.:    .|.|.:     :|:|:|.::....
Zfish   241 SRPFVQDATLAGFDWGSYLEKSGL-LAAPVSCFRH----VPLCAQWEDVYVGLKVEVLNTHTALP 300

  Fly   865 -SLFCVCSIVEVRGYRLKLSFDGY--SSMYDFWVNADSQDIFPPGWCDETARVLQAPKDYNSERF 926
             .::.:.::|::.||:..|.::|:  ...:|.|.|..:.|:.|.|||....:.|..|::.:.:
Zfish   301 SKVYWIATVVQLAGYKALLRYEGFEDDDRHDLWCNLGTADVHPIGWCAVNNKPLVPPQEVHQQ-- 363

  Fly   927 SWSRYLVK--TGGKAAP---------------------------------------------RAL 944
            .|..||::  .|....|                                             |.|
Zfish   364 DWKSYLMERLVGAHTIPVDFHVKMADSLRCPFRQGVRVEVVDRSQVSRTRLAVVDTVIGGRLRLL 428

  Fly   945 F------------------------GHLNMQQQMD---------VRNG----------------- 959
            :                        .|:...:.:|         |..|
Zfish   429 YEDAGLGPSGEVLSDFWCHMQSPLVHHVGWSETVDHSIKETDTNVNMGSHPAFRRVHQNSVPDQF 493

  Fly   960 ------------FAVGMHLEAEDLNDTGKICVATVTDI-LDERIRVHFDG--------WDDCYDL 1003
                        |..||.:||.|..:.|.||||:|..: ||..|.|..||        | .||
Zfish   494 KKLRTVYMGATFFKEGMKIEAIDPLNLGNICVASVRKVLLDGYIMVGIDGVEIGDGSDW-FCY-- 555

  Fly  1004 WVHITSPYIHPCGWHEGRQ-QLIVPPDYQKSAFIWDDYISEVGGMAASKELF-TPRQPMEYQERM 1066
              |.:|..|.|.|:.|... .|.|||.|.::.|.|..|:.|.|.:||.:.|| |......:...|
Zfish   556 --HASSHAILPVGYCENNDIPLTVPPGYDQATFTWPVYLEETGAVAAPQRLFNTDDVGHGFTSGM 618

  Fly  1067 KLEVVDQRNPCLIRPATVVTRKGYRVQLHLDCWPTEYYFWLEDDSPDLHPIGWCEATSHELETPP 1131
            |||.||...|.|:..|||....|..:.||.|.|..|:..|::..||:::|:||||.|.::|:.|.
Zfish   619 KLEAVDLMEPRLVCVATVRRCVGRLLLLHFDGWEPEFDQWVDCQSPEIYPVGWCEITGYQLQPPI 683

  Fly  1132 GYLQPKSVMPCDVEGCRGFGNAKRFNLNVHALRECCPYAPENWRQWRSKTVKPPRVAPENIRRGW 1196
            |...|:.                  ..:.||.::..|:..:..|::..|..|.......|.....
Zfish   684 GPEPPQG------------------QEHSHASKKAKPFKGKRKRRFLRKNAKINLKTQTNENTEM 730

  Fly  1197 AKKTKRACSEAKQA---IKEDSQQEIVYPKVAEVVQAKRKTSPCEEKVVKKQK--------QMQK 1250
            .:..:.|.:..|.:   ||.:.::|:    :|..|:.:...:|.......|:.        :.:|
Zfish   731 IQSQEAANTSDKPSTLQIKTEPEEEV----IAVRVKVEELETPILSSAQSKESHQGALTTFKREK 791

  Fly  1251 EEDAEQVPDE 1260
            ::|.::..||
Zfish   792 DDDEDEEEDE 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	26/105 (25%)
		MBT	929..1028	CDD:214723	39/217 (18%)
		MBT	1038..1130	CDD:214723	35/92 (38%)
		SAM_PNT	1279..1366	CDD:280377
l3mbtl2	NP_956326.1	THAP	4..89	CDD:283206
		MBT	257..357	CDD:214723	26/104 (25%)
		MBT	366..467	CDD:214723	8/100 (8%)
		MBT	511..582	CDD:280910	28/75 (37%)
		MBT	591..682	CDD:214723	35/90 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910