DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)mbt and scml2

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_009304396.1	Gene:	scml2 / 559561	ZFINID:	ZDB-GENE-130530-546	Length:	723	Species:	Danio rerio

Alignment Length:	759	Identity:	165/759 - (21%)
Similarity:	264/759 - (34%)	Gaps:	229/759 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   791 QTNYKPHKSLSAIQEQLQQRQKDKPRKPFRWSEYLKSKGKDVAAPIHLFLNPFPISPNC------ 849
            |.:.|.||..|....: ..:...|..:.|.|..||:.            .:..|.||:|
Zfish     6 QKDKKHHKEKSGRNNE-DSQPSQKLTEAFSWEMYLRE------------TSSCPASPSCFRQSRV 57

  Fly   850 -----FEIGMKLEAIDPENCSLFCVCSIVEVRGYRLKLSFDGYSSMYDFWVNADSQDIFPPGWCD 909
                 |.:|||:||.||.|.|.:|:.:::.:.|.||:|..||..|..|||...|:.||.|.|.|:
Zfish    58 PPANDFRVGMKVEACDPRNASSWCIATVMGLMGVRLRLRLDGSDSTNDFWRLVDAADIQPIGTCE 122

  Fly   910 ETARVLQAPKDYNSERFSWSRYLVKT--GGKAAPRALFGHLNMQQQMDVRNGFAVGMHLEAEDLN 972
            ::..:||.|..:.....||..:|:||  |.:.||.:.|   ..:.....:|.|..||.|||.|..
Zfish   123 KSGDMLQPPLGFRMNASSWPMFLLKTLSGAEMAPSSAF---KKEPPRPTQNFFKAGMKLEAVDRK 184

  Fly   973 DTGKICVATVTDILDERIRVHFDGWDDCYDLWVHITSPYIHPCGWHEGRQQLIVP---------- 1027
            :...||.||:.::..::|.:.||||...:|.|....|..|.|.||.:.....:.|
Zfish   185 NPYLICPATIGEVRGDKIFIMFDGWRGAFDYWCQFDSRDIFPVGWCQLTNHSLQPPGNCFTIPKT 249

  Fly  1028 --PDYQKSAFIWDDYIS-------------------------EVGGMAASKE------------- 1052
              |...:.:..|....|                         .:..:.|:.|
Zfish   250 LLPSVSRPSPSWRPMQSPYRLPHPLPPLPVRKGVRGRRPKSQTIAMLKAAAEAAAAGNSPSQNGQ 314

  Fly  1053 ----------LFTPRQPMEYQER--------------------MKLEVVDQR------------- 1074
                      :.:|..|..|::|                    :...|.|.|
Zfish   315 SQPTSAHKSPISSPLTPKPYKKRGPKPGSKRKPKVPHSLSSPILSSSVSDGRLSSLQTTRDSGVV 379

  Fly  1075 -------------NPCLIR-----------PATVVTRKGYRVQLHLDC--WPTEYYFWLEDDSP- 1112
                         .|.|.|           |..|.|...:.||..:||  .|...:.:|:..|.
Zfish   380 STVCVYVNKHGNSGPHLDRKLLLQLPDHFGPGPVNTVLQHAVQACVDCAFQPKALFSFLQSQSDG 444

  Fly  1113 ----------DLHPIGWCEATSHE-----LETPPGYLQPKSVMPCDVEGCRGFGNAKRFN---LN 1159
                      .:|.:....|:|..     |||...:||           |....:::.|:   .:
Zfish   445 GEIIRVRSEGGIHYVKLPTASSASFVLRFLETLCHHLQ-----------CDNLFSSQPFSPLTSS 498

  Fly  1160 VHALRECCPYAPENWRQWRSKTVKPPRVAPENIRRGWAKKTKRACSEAKQAIKEDSQQEIVYPKV 1224
            .|.     ||.       |||:||.......::.|| .::..|..|....|:....|:....|..
Zfish   499 THT-----PYE-------RSKSVKEETSEALSVARG-TRRFNRDSSAYSTALSPKLQRTEALPSD 550

  Fly  1225 AEVVQAKRKTSPCEEKVVKKQKQMQKEEDAEQVPDERSLAIARSFVKDYG-----PQFLPNYRLW 1284
            ..:..|:...| .|::.:::......:..|.:.|..||.:   .|....|     |...|..|..
Zfish   551 ETIAHAENGAS-TEQQFLEESMDSASKSVAPRPPAHRSTS---EFHTPTGSSPHYPSHPPLLRGL 611

  Fly  1285 QLN------------------------SAFKLDDVRTNPLHWTSWDVCEYIERALDST-----DI 1320
            ..|                        .|.:.|..:|:....:||.:.|.::...|:.     ..
Zfish   612 SSNPAEPRTHRRVEGRLSASSTTGPDHQATEKDPSKTSNKSPSSWSIEEVMQFVRDADPQALGPH 676

  Fly  1321 AKVIFEQDIDGRALLMLGRKELDTYLKLKVGPAVKLYSLILNLR 1364
            |::..:.:|||:||::|....:..|:.||:|||:||...|..|:
Zfish   677 AELFRKHEIDGKALMLLRSDMIMKYMGLKLGPALKLCHHIEKLK 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	35/106 (33%)
		MBT	929..1028	CDD:214723	32/112 (29%)
		MBT	1038..1130	CDD:214723	28/214 (13%)
		SAM_PNT	1279..1366	CDD:280377	27/115 (23%)
scml2	XP_009304396.1	MBT	36..131	CDD:214723	35/106 (33%)
		MBT	142..240	CDD:214723	31/100 (31%)
		DUF3588	381..490	CDD:288954	22/119 (18%)
		SAM_Scm	650..721	CDD:188977	21/71 (30%)
		SAM	653..722	CDD:197735	21/68 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583961
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840