DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)mbt and si:ch211-230g15.5

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_017209418.1	Gene:	si:ch211-230g15.5 / 556561	ZFINID:	ZDB-GENE-091204-280	Length:	960	Species:	Danio rerio

Alignment Length:	880	Identity:	179/880 - (20%)
Similarity:	292/880 - (33%)	Gaps:	317/880 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LSMASAEAKQLQRNISLSMSPANGGVISPSTANCNGVASASGGNPNPNSLLT-LAPRKEELRFLP 67
            :|.||: ::|..:.|||..:|.:..::....:....|...|     |.:||. .:|...:.:.|.
Zfish    95 VSQASS-SQQTPKTISLPNTPGSTALVRGGQSAVTAVRKIS-----PQTLLLGKSPSTSQAQMLL 153

  Fly    68 LAPMGGNKTCNITISNVQPMKSKLKSVNIVPNSIKSAGAGATVGSADAPLFQLVPSPSNPSQPLV 132
            .|.|      .|..|.|:|      .|..:.:|..|:.:.::..|:.:.    .||.|:|..|..
Zfish   154 RAQM------LILTSAVRP------DVPALSSSFSSSSSFSSSSSSSSS----TPSSSSPRFPST 202

  Fly   133 AILAPNRKTTLLGGGASNGQPVVIRSGTPLHKNSLTV--------ETSNKP------------IQ 177
            .:                 |.:.||...|   .:||:        .||::|            ::
Zfish   203 QL-----------------QSLTIRPPPP---GTLTIPPNLPLKPTTSSQPPPLSCPRIPTFHLR 247

  Fly   178 PGGSAAAAAVGGGT-GGAPLTLVGK--------TVVPPKIQAATPVQIPSTG-----------PG 222
            |...|.|....|.| ..:|.:...:        ||.||.:.|  |.|..:..           |.
Zfish   248 PSQPANAPGKDGATKSESPTSQTAQTKTPVRHLTVPPPSLYA--PAQAHALAKQKLNSSSLKRPH 310

  Fly   223 AQVSLLANPLKPRAPLILSKVAVDKLRLKFSQVKSNPNALVLGKANHVKKLLTSPNPSGEDKTRS 287
            :|:|:..:|                    |:|..:.||:........:.:|...|:      |::
Zfish   311 SQISIPQHP--------------------FNQRHTPPNSPPATPKKPLPELKRCPS------TQA 349

  Fly   288 TQKNNKQNTSASQLKP------VVAPKTAMPIATEVP----------------------TADNNK 324
            :|..:.|:.|.|...|      :..|...:|:.:..|                      |...:|
Zfish   350 SQSISPQSASVSITVPSPARAHLTPPTLTLPLRSSSPGGSLLATKQLLRIALSSASAQCTNGQSK 414

  Fly   325 MS-------LIKSKPVAIKAVPLPSQEAPIVPAVAPVVTSPEKVDVKPT-----AKPSIKTAPKP 377
            .:       ||:|||:....:..|  |.|..|.:.| .|.|:.|.:.|:     |.|.|.|.|..
Zfish   415 TATVSPPHDLIQSKPLLSPVLAKP--ECPTQPLLTP-NTCPQLVQLSPSRQTTAATPLITTPPLA 476

  Fly   378 TPKPLEMSVNGPAKEKKAPAKEQKQKTMDKPPVVKEIAQHTPCGPKELPKLKRSKSFVSNHPASP 442
            :|                      |:.....||:..::..:...|                |.||
Zfish   477 SP----------------------QRASPPSPVLPLVSTSSILAP----------------PQSP 503

  Fly   443 VANNERRHSVAIMAKEVDVIEQPSAAIETITIEDDDESEEEQQKPEIKKTPKQNQKPEKQEAPKK 507
            :.:                 :.|:...||:. |..|..||::|....::||:..:.|    ||:|
Zfish   504 LTS-----------------QSPTQITETLK-EPKDRKEEQKQGTVPEQTPQDLKCP----APQK 546

  Fly   508 K------QIPMPILPAGITISTTSTAKKKAVRKNSSVTTISSSSSDSSSYSDVEVVPTKKTEKEL 566
            |      |:|             |.|.:|.:  |..:....:|.:|..         .|.::|..
Zfish   547 KMTQAVDQLP-------------SEASEKVL--NKIIVCTENSRTDGQ---------IKTSQKNE 587

  Fly   567 SMLPGISIIKAESLPLSREDFERSLRCDEQVPQTPPKSSSSSSSGSHASEMSP-PPKLADPKPSS 630
            :..|.::...||.              |:|..:|..:|.:.|:..|.:|:||| ...:|.|...|
Zfish   588 THSPSVAPWPAEK--------------DDQCEETSTQSDNHSAISSLSSDMSPIQSSIAQPLDMS 638

  Fly   631 P-----PAKNAKKANDHDANPSP---SSKTNDFKKSMMQNLNMLKWRGQQPANLQNSTVRFELNE 687
            |     |.|      .|.....|   ||..:..|.:          .|||.:......|...|.|
Zfish   639 PVDSCFPPK------FHPVLERPLVQSSTLSQMKDT----------EGQQASGAPKPLVLTHLVE 687

  Fly   688 FNFLQINERCQP-RQGPAAYFERPLYD-------RPGRRPSACVHP------------------- 725
             .|: |.|..:| ....::....|:.|       .||..||...||
Zfish   688 -GFI-IQEGLEPFPVSRSSLMVGPVQDSGVNGVKEPGLIPSGSEHPEDSTDSDDEDGVANSNGVG 750

  Fly   726 ----LLYLCQRCNFHGPAADF-LAPHFCSVGCVRR 755
                |:..||.|...|.|..| .:..|||..|.:|
Zfish   751 RAHKLVLQCQFCKRKGTAQTFPRSKRFCSKSCAKR 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723
		MBT	929..1028	CDD:214723
		MBT	1038..1130	CDD:214723
		SAM_PNT	1279..1366	CDD:280377
si:ch211-230g15.5	XP_017209418.1	SAM_Ph1,2,3	889..957	CDD:188976
si:ch211-230g15.5	XP_017209418.1	SAM	891..957	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I5098
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.960