DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)mbt and sfmbt2

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_005164891.1	Gene:	sfmbt2 / 555450	ZFINID:	ZDB-GENE-041210-196	Length:	861	Species:	Danio rerio

Alignment Length:	865	Identity:	174/865 - (20%)
Similarity:	277/865 - (32%)	Gaps:	327/865 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   819 FRWSEYLKSKGKDVAAPIHLFLNPFPIS-PNCFEIGMKLEAIDPENCSLFCVCSIVEVRGYRLKL 882
            |.|.|||:..|. .||| |.......:| .:.|:.|||||..:..:...:.|.:|:...|..|.|
Zfish    10 FNWEEYLEDTGA-TAAP-HTSFRHVELSLQSSFQPGMKLEVANKGSVDTYWVATIITTCGQLLLL 72

  Fly   883 SFDGYSS--MYDFWVNADSQDIFPPGWCDETARVLQAPKDYN-------SERFS-WSRYLVK--T 935
            .:.||..  ..|||.:..:.::.|.|||.:..:.||.|:| |       .|::| |:.:|:|  |
Zfish    73 RYCGYGEDRKADFWCDVMTAELHPVGWCAQNDKTLQPPED-NVYLRAAIKEKYSDWTEFLIKELT 136

  Fly   936 GGKAAPRALF-GHLNMQQQMDVRNGFAVGMHLEAEDLNDTGKICVATVTDILDERIRVHFDGWDD 999
            |.:.||..|. |.|..:..:|:   ...|..||..|.::........|...:..|:.:.:.|.:|
Zfish   137 GSRTAPANLLEGPLRGKNTVDL---IMEGSILELRDASEPSVYWATQVQRNVGGRLCLSYVGLND 198

  Fly  1000 -CYDLWVHITSPYIHPCGWHEGRQQLIVPP----DYQKSAFIWDDYISEVGGMAASKELFTPRQP 1059
             .|.:|:......:.|.||.:.....:.||    |.:.|: .|...:.|....|.:..|     |
Zfish   199 PSYYMWMFYLDTRLRPLGWAKENNLPMKPPTDLCDLRSSS-EWTTALDEATAEALNNPL-----P 257

  Fly  1060 ME------------YQERMKLEVVDQRNPCLIRPATVV-TRKGYRVQLHLD-------------- 1097
            :|            ::..||||:|....|..|.|.:|. ....|..|:.:|
Zfish   258 LEVFKDHADLHTHSFRAGMKLEMVSPVEPFHICPVSVTKVYNEYHFQITVDDLTADATPTSAVCH 322

  Fly  1098 -----------------------------------------------CWPTEYY-------FWLE 1108
                                                           |:|....       .|||
Zfish   323 AESPGILPVQWCLKNGVELERPRGFETQDFDWADYLKHTSTEAAPDACFPNASQSRGFCKDMWLE 387

  Fly  1109 DDSP----------------------------------------DLHPIGWCEAT----SHELET 1129
            ..:|                                        ::.|:|||||.    :|.|:|
Zfish   388 AVNPLHPAELCVARITQVKGCLLWLRLEGLTKPLPDCIVDVESMNIFPVGWCEANGYPLTHSLKT 452

  Fly  1130 ------------PPGYLQPK----------SVMPCD---VEG---C-RGFGNAKRFN---LNVHA 1162
                        |...|.|.          |..|.|   |.|   | :.|.|.:.|:   ||...
Zfish   453 VCLPQKKIAVVQPEKQLAPSQSPDIPISLCSSAPMDSGLVNGKYCCSQLFINHRCFSGPYLNKGR 517

  Fly  1163 LRE---------CCPYAPENWRQWRSKTVKPPRV--------------APENIRRGWAKKT---- 1200
            :.|         |.....|......:...||.||              ..|.::..:..|:
Zfish   518 IAELPKAVGPGKCAVVLKEILTMLINSAYKPGRVLRELQMVEDPQWNCQEETLKAKYKGKSYRST 582

  Fly  1201 --------------KRAC------------------------SEAKQAIKEDSQQEIVYPKVAEV 1227
                          :|.|                        |:.|.......::::..|.:.|.
Zfish   583 MRIVRTADQVSEFCRRVCERLQCCLNLFGPTFVSDKCPENCSSQTKTKYTYYKKRKVGRPSLGEN 647

  Fly  1228 VQAKRKTSPCEEKVVKKQKQMQK--------------------------EEDAEQVPDERSLAIA 1266
            .|....:.|...:..:|...:||                          :||.|:...|.|.:..
Zfish   648 AQDGDLSKPARRRKKRKAIFVQKKRRSSIVGYHTTESPQDSDYNYDEDEDEDFEEWGSEASSSSL 712

  Fly  1267 RSFVKDYGPQFLP-----------------------------------NYRLWQL--NSAFKLDD 1294
            |.....:..  ||                                   :|...|:  ::..|::.
Zfish   713 REEASAHNS--LPRRGRPPRRAALQRRMTHPGSETSDRISPRRTTRSVSYSQNQMARDTNVKMES 775

  Fly  1295 VR--------TNPLHWTSWDVCEYIERALDSTDIAKVIFEQDIDGRALLMLGRKELDTYLKLKVG 1351
            ..        ||||.|:..||.::| .:.|...:||:..||||||:|||:|....:...:.||:|
Zfish   776 TEEEDRLVLDTNPLQWSVSDVVDFI-TSTDCASLAKIFQEQDIDGQALLLLTLPTVQECMDLKLG 839

  Fly  1352 PAVKLYSLILNLRIAVVCKF 1371
            ||:||...|..:::|...::
Zfish   840 PAIKLCHQIERVKVAFYSQY 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	31/98 (32%)
		MBT	929..1028	CDD:214723	23/102 (23%)
		MBT	1038..1130	CDD:214723	32/228 (14%)
		SAM_PNT	1279..1366	CDD:280377	33/131 (25%)
sfmbt2	XP_005164891.1	MBT	13..110	CDD:214723	31/98 (32%)
		MBT	134..228	CDD:302657	21/96 (22%)
		MBT	277..348	CDD:280910	11/70 (16%)
		MBT	356..447	CDD:214723	12/90 (13%)
		DUF3588	498..612	CDD:288954	17/113 (15%)
		SAM_Scm-like-4MBT1,2	777..861	CDD:188980	30/84 (36%)
		SAM	788..852	CDD:197735	27/64 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583957
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840