DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)mbt and Sfmbt1

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001160003.1	Gene:	Sfmbt1 / 54650	MGIID:	1859609	Length:	863	Species:	Mus musculus

Alignment Length:	867	Identity:	180/867 - (20%)
Similarity:	295/867 - (34%)	Gaps:	339/867 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   819 FRWSEYLKSKGKDVAAPIHLFLNPFPISPNCFEIGMKLEAI---DPENCSLFCVCSIVEVRGYRL 880
            |.|.:||:..| ....|...|.:......|.|..|||||..   |||.   :.|.:|:......|
Mouse    20 FSWEDYLEETG-STTVPYASFKHVDIRLQNGFAPGMKLEVALKNDPET---YWVATIITACEQLL 80

  Fly   881 KLSFDGYSS--MYDFWVNADSQDIFPPGWCDETARVLQAPKDYNSERFSWSRYLVKT--GGKAAP 941
            .|.::||..  ..|||.:.....::|.|||.:..:.|:||:....:...|:.:|.:|  |....|
Mouse    81 LLRYEGYGEDRKADFWCDIRKAGLYPIGWCQQNKKTLEAPEGIRDKVSDWNAFLQQTLIGACGPP 145

  Fly   942 RALF-GHLNMQQQMDVRNGFAVGMHLEAEDLNDTGKICVATVTDILDERIRVHFDGWD--DCYDL 1003
            .:|. |..|.:..:|:   .|.|..||.:|..|:....:.||.:.:..|:::.::|.:  |.::.
Mouse   146 VSLLEGLRNGRNPLDL---IAPGSKLECQDFRDSLSTWLVTVVENIGGRLKLRYEGLESRDGFEH 207

  Fly  1004 WVHITSPYIHPCGWHEGRQQLIVPP---DYQKSAFIWDDYISEVGGMAASKE-------LFTPRQ 1058
            |::...|::|..||...:...:.||   .:.||...|.:.:::|      ||       ||..:|
Mouse   208 WLYYLDPFLHHIGWAAQQGCDLQPPLAIKHLKSEADWQEILAKV------KEEEPLPSYLFKDKQ 266

  Fly  1059 PM---EYQERMKLEVVDQRNPCLIRPATVV--------------------TRKG----------Y 1090
            .:   |:...||||.||..:|..|.|||:.                    ||:.          :
Mouse   267 VIGTHEFSINMKLEAVDPWSPFGISPATIAKVFDDKYFLVEMDDLRPEDHTRRSFVCHANSPGIF 331

  Fly  1091 RVQ------LHLD---------------------------CWP---TEY---------------- 1103
            .||      ||::                           |:|   :|:
Mouse   332 PVQWSLKNGLHINPPPGFRSQDFDWADYLKQCGAEAAPQKCFPQSISEHQFKENMKLEAVNPLFP 396

  Fly  1104 --------------YFWLE--------------DDSPDLHPIGWCEATSHELETPP--------- 1131
                          |.||:              .:|.::.|:||||...|.|.||.
Mouse   397 EEVCIATVTAVRGSYLWLQLEGSKKPVPEFIVSAESMNIFPLGWCETNGHPLSTPRRARGHKLRK 461

  Fly  1132 -GYLQPKSVMPCDVEGCRGFGNAKRFNLN-VHAL----RECCPYAPENWRQWRSKTVKPPRVA-- 1188
             ..:||:.    .:...|......:..|| .|::    :.|||....|.|.:....:...|:|
Mouse   462 IAVVQPEK----QILSSRTVHEGLKNQLNSTHSVMINGKYCCPKIYFNHRCFSGPYLNKGRIAEL 522

  Fly  1189 PENIRRG---------------WAKKTKRACSEAKQAIKEDSQQEIVYPKVAEVVQAK------- 1231
            |:.:..|               .|.|..|...|.:  :.:||    |:....||::||
Mouse   523 PQCVGPGNCVLVLREVLTLLINAAYKPSRVLRELQ--LDKDS----VWHGCGEVLKAKYKGKSYR 581

  Fly  1232 ----------RKTSPCEEKVVK------------------------------------------- 1243
                      |.|..|.:..:|
Mouse   582 ATVEIVRTADRVTEFCRQTCIKLECCPNLFGPRMVLDTCSENCSVLTKTKYTHYYGKKKNKRIGR 646

  Fly  1244 ----------------KQKQMQK-----------------------------EEDAEQVPDERSL 1263
                            |:::.:|                             ||||:. .||.||
Mouse   647 PPGGHSNLSCALKKSSKRRKRRKNIFVHKKKRSSASVDNTPVGSPQGSGGEDEEDADD-GDEDSL 710

  Fly  1264 ----------------------AIARSFVKDYGPQFLP-----NYRLWQLNSA------------ 1289
                                  :.:.|..:...|..||     |.|..|.:|.
Mouse   711 TEGSTSEQQEELQEESEVSEKKSSSSSPTQSETPTPLPPDTQTNKRDAQTSSVSDDENKPPSPKE 775

  Fly  1290 --FKLDD---VRTNPLHWTSWDVCEYIERALDSTDIAKVIFEQDIDGRALLMLGRKELDTYLKLK 1349
              .::|:   :.:|||.|:..||..:| |:.|...:|::..:|:|||:|||:|....:...:.||
Mouse   776 IRIEVDERLHLDSNPLKWSVADVVRFI-RSTDCAPLARIFLDQEIDGQALLLLTLPTVQECMDLK 839

  Fly  1350 VGPAVKLYSLILNLRIAVVCKF 1371
            :|||:||...|..::.|...:|
Mouse   840 LGPAIKLCHHIERIKFAFYEQF 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	29/100 (29%)
		MBT	929..1028	CDD:214723	24/103 (23%)
		MBT	1038..1130	CDD:214723	38/211 (18%)
		SAM_PNT	1279..1366	CDD:280377	32/108 (30%)
Sfmbt1	NP_001160003.1	MBT 1	20..120		31/103 (30%)
		MBT	23..120	CDD:214723	29/100 (29%)
		MBT 2	128..232		25/106 (24%)
		MBT	132..232	CDD:214723	24/102 (24%)
		MBT 3	242..346		25/109 (23%)
		MBT	245..346	CDD:214723	24/106 (23%)
		MBT 4	354..451		14/96 (15%)
		MBT	358..451	CDD:214723	14/92 (15%)
		SLED	499..614	CDD:371916	23/120 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..773		18/135 (13%)
		SAM_Scm-like-4MBT1,2	779..863	CDD:188980	29/84 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839874
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840