DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)mbt and Phc2

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001182059.1	Gene:	Phc2 / 54383	MGIID:	1860454	Length:	850	Species:	Mus musculus

Alignment Length:	699	Identity:	160/699 - (22%)
Similarity:	268/699 - (38%)	Gaps:	164/699 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PLSMASAEAKQLQRNISLSMSPANGGVI----SPSTANCNGVASAS---GGNPNPNSLLTLAP-- 58
            |.|..|::|.....:::|:.|||...:|    |.::|..:|:|..:   |...:|....:.|.
Mouse   126 PGSSVSSQAPAQSSSLNLAASPAAAQLINRAQSVNSAAASGLAQQAVLLGNTSSPALTASQAQMY 190

  Fly    59 -RKEELRFLPLAPMGGNKTCNITISNVQ-----------PMKSKLKSVNIVPNSIKSAGA-GATV 110
             |.:.|.|.|.|          |::.||           |..::::::.:......:|.| |...
Mouse   191 LRAQMLIFTPTA----------TVATVQPELCTGSPARPPTPAQVQNLTLRTQQTPAAAASGPPP 245

  Fly   111 GSADAPLFQLVPSPSNPSQPLVAILAPNRKTTLLGGGASNGQPVVIRSGTPLHKNSLTVETSNKP 175
            .....|...|.|:||: ||||.   ||.:..|:..|..:..:|    |||.....:|.....|..
Mouse   246 TQPVLPSLALKPTPSS-SQPLP---APPQGRTMAQGSPAGAKP----SGTDNAPETLKAGDGNCN 302

  Fly   176 IQ--PGGSAAAAAVGGGTGGAPLTLVGKTVVPPKIQAATPVQIPSTGPGAQVSLLANPLKPR-AP 237
            ::  ||...|..||      |...|:.......:.....| |.|:..|..|......|..|| ||
Mouse   303 MEGRPGPGRAVPAV------ATHPLIAPAYAHLQSHQLLP-QPPAKHPQPQFVAQQQPQPPRPAP 360

  Fly   238 LILSKVAVDKLRLKFSQVKSNP--NALVLG----------KANHVKK----------LLTSPNPS 280
            .:.|:..:..:....: ::|:|  :||.||          ...||.|          .|.:.:.:
Mouse   361 QVQSQPQLASVSPSLA-LQSSPEDHALPLGSVTQALPLQCSTTHVHKPGNSQQCHLPTLDTGSQN 424

  Fly   281 GEDKTRSTQKNNK-QNTSA--SQLKPV--VAPKTAMPIA-TEVPTADNNKMSLIKSKPVAIKAVP 339
            |..:..|.....: |:|||  .|::|.  |.|:...|.. .||..|:       ||.||| :..|
Mouse   425 GHPEGGSHPPQRRFQHTSAVILQVQPASPVTPQQCAPDDWKEVVPAE-------KSVPVA-RPGP 481

  Fly   340 LPSQEAPIVPAVAPVVTSPEKVDVKPTAKPSIKT------APKPTPKPLEMSVNGPAKEKKAPAK 398
            .|.|:| |:||:...:..|:..:::..  |:.:|      |......|...|.||.:....|...
Mouse   482 SPHQQA-IIPAIPGGLPGPKSPNIQQC--PAHETGQGIVHALTDLSSPGMTSGNGNSASSIAGTA 543

  Fly   399 EQKQKTMDKPP--VVK-EIAQHTPCGPKELPKLKRSKSFVSNHPASP---------VANNERRHS 451
            .|..:  :|||  :|| :|..|.            .:.||....|.|         |.|.:::::
Mouse   544 PQNGE--NKPPQAIVKPQILTHV------------IEGFVIQEGAEPFPVGRSSLLVGNLKKKYA 594

  Fly   452 VAIMAKEVDVIEQPSAAIETITIEDDDESEEEQQKPEIKKTP-----------------KQNQKP 499
            ...:.      |:|.....|.|.:.:.|....|:..| :.||                 |::::.
Mouse   595 QGFLP------EKPPQQDHTTTTDSEMEEPYLQESKE-EGTPLKLKCELCGRVDFAYKFKRSKRF 652

  Fly   500 EKQEAPKKKQIPMPILPAGITISTTSTAKKKAVRKNSSVTTISSSSSDSSSYSDVEVVPTKKTEK 564
            ......|:..:       |.|.........::..:.:..||.:...:..:|...:    ||.|:|
Mouse   653 CSMACAKRYNV-------GCTKRVGLFHSDRSKLQKAGTTTHNRRRASKASLPTL----TKDTKK 706

  Fly   565 ELSMLPGISIIKAESLPLSREDFERSLRCDE----QVPQTPPKSSSSSS 609
            :.|....:|:..|..|..|:||   |.||.:    :.|.:|..:|||:|
Mouse   707 QPSGTVPLSVTAALQLAHSQED---SSRCSDNSSYEEPLSPISASSSTS 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723
		MBT	929..1028	CDD:214723
		MBT	1038..1130	CDD:214723
		SAM_PNT	1279..1366	CDD:280377
Phc2	NP_001182059.1	Disordered. /evidence=ECO:0000269\|PubMed:27827373	1..79
		Interaction with BMI1. /evidence=ECO:0000269\|PubMed:27827373	33..56
		PHA03247	<216..540	CDD:223021	85/350 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	233..314		25/88 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..386		13/52 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	402..436		6/33 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..553		7/26 (27%)
		HD1	550..579		11/40 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..624		6/32 (19%)
		PHC2_SAM_assoc	662..780	CDD:374673	25/105 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..712		8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	725..764		12/31 (39%)
		SAM_Ph1,2,3	781..849	CDD:188976
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839870
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840