DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)mbt and ph-d

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_524794.2	Gene:	ph-d / 44889	FlyBaseID:	FBgn0004860	Length:	1537	Species:	Drosophila melanogaster

Alignment Length:	942	Identity:	162/942 - (17%)
Similarity:	297/942 - (31%)	Gaps:	320/942 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QLQRNISLSMSPANGGVISPSTANCNGVASA-SGGNPNPNSLLTLAPRKEELRFLPLAPM----- 71
            |.|..:...:|.||||          |.||| :||..:|.:......::.......::||
  Fly   182 QQQLQLQQQLSEANGG----------GAASAGAGGAASPANSQQSQQQQHSTAISTMSPMQLAAA 236

  Fly    72 ----GGNKTCNITISNVQPMKSKLKSVNIVPNSIKSAGAGATVGSADAPLFQLVPSPSNPSQPLV 132
                ||:.|...|:..:||..|.|     .|..|.|.
  Fly   237 TGGVGGDWTQGRTVQLMQPSTSFL-----YPQMIVSG---------------------------- 268

  Fly   133 AILAPNRKTTLLGGGASNGQPV-VIRSGTPLHKNS---LTVETSNKPIQPGGSAAAAAVGGGTGG 193
                     .||..|....||: ||.:|.|...|.   ||..|.|.....||.|..|  ||...
  Fly   269 ---------NLLHPGGLGQQPIQVITAGKPFQGNGPQMLTTTTQNAKQMIGGQAGFA--GGNYA- 321

  Fly   194 APLTLVGKTVVP------PKIQAATPVQIPSTGPGAQVSLL------------------------ 228
                    |.:|      |:....:||.:.|..|..|.:||
  Fly   322 --------TCIPSNHNQSPQTVLISPVNVISHSPQQQQNLLQSMAAAAQQQQLTQQQQQQLNQQQ 378

  Fly   229 --ANPLKPRAPL--ILSKVAVD---KLRLKFSQVKSNPNALVLGKANHVKKLLTSPNPSGEDKTR 286
              .|..:.:..|  .|:||.||   ||..|..|..:..::.|        :..|.|..:|..:|:
  Fly   379 QQLNQQQQQQQLTAALAKVGVDAQGKLAQKVVQKVTTTSSTV--------QAATGPGSTGSTQTQ 435

  Fly   287 STQKNNKQNTSASQLKPVVAPKTAMPIATEVPTADNNKMSLIKSKPVAIKAVPLPSQEAPIVPAV 351
            ..|:..:|....:|
  Fly   436 QVQQVQQQQQQTTQ--------------------------------------------------- 449

  Fly   352 APVVTSPEKVDVKPTAKP------SIKTAPKPTPKPLEMSVNGPAKEKKAPAKEQKQKTMDKPPV 410
                |:.:.|.|..:..|      |::||        ::...|.|::.:.|...|....:.....
  Fly   450 ----TTQQCVQVSQSTLPVGVGGQSVQTA--------QLLNAGQAQQMQIPWFWQNAAGLQPFGS 502

  Fly   411 VKEIAQHTPCGPKELPKLKRSKSFVSNHPASPVANNERRHSVAIMAKEVDVIEQPSAAIETITIE 475
            .:.|.::.|.|.:.:        |:...||:.....::...:     :.:|.:.|:.|...:...
  Fly   503 NQIILRNQPDGTQGM--------FIQQQPATQTLQTQQNQII-----QCNVTQTPTKARTQLDAL 554

  Fly   476 DDDESEEEQQKPEIKKTPKQN--------QKPEKQEAPKKKQIP-MPILPAGITISTTSTAKKKA 531
            ...:.:::||.....:|.:|.        |:.::|......|.| .|::|...|          .
  Fly   555 APKQQQQQQQVGTTNQTQQQQLAVATAQLQQQQQQLTAAALQRPGAPVMPHNGT----------Q 609

  Fly   532 VRKNSSVTTISSSSSDSSSYSDVEVVPTKKTEKELSMLPGISIIKAESLPLSRED-FERSLRCDE 595
            ||..|||:|.::.:.        .::..|...|:..:.|.::.:|.|...::.:: ....|...:
  Fly   610 VRPASSVSTQTAQNQ--------SLLKAKMRNKQQPVRPALATLKTEIGQVAGQNKVVGHLTTVQ 666

  Fly   596 QVPQTPPKSSSSSSSGSHASEMSPPPKLADPKPSSPPAKNAKKANDHDANPSPSSKTND----FK 656
            |..|........:::|:....||         .:..|.........|.|..:...|...    |:
  Fly   667 QQQQATNLQQVVNAAGNKMVVMS---------TTGTPITLQNGQTLHAATAAGVDKQQQQLQLFQ 722

  Fly   657 KSMMQNLNMLKWRGQQPANL----QNSTVRFELNEFNFLQINERCQPRQGPAAYFERPLYDRPGR 717
            |..:....||:   ||.|.:    |.:.|:.:..:...:...::...:|..|...::....:..:
  Fly   723 KQHILQQQMLQ---QQIAAIQMQQQQAAVQAQQQQQQQVSQQQQVNAQQQQAVAQQQQAVAQAQQ 784

  Fly   718 RPSACVHPLLYLCQRCNFHGPAADFLAPHFCSVGCVRRSQKRRLPQSTQKESKISRTQLEQTAGT 782
            :                                   :|.|::::.|:..:..:......:|....
  Fly   785 Q-----------------------------------QREQQQQVAQAQAQHQQALANATQQILQV 814

  Fly   783 APD---LPQKRQTNYKPHKSLSAIQEQLQQ--------------RQKDKPRKPFR---------- 820
            ||:   ...::|...:.|..|  ||:||||              :|:.:.|:..:
  Fly   815 APNQFITSHQQQQQQQLHNQL--IQQQLQQQAQAQVQAQVQAQAQQQQQQREQQQNIIQQIVVQQ 877

  Fly   821 ----WSEYLKSKGKDVAAPIHLFLNPFPISPN 848
                .|:..:.:.:..:..:.|...||.:||:
  Fly   878 STGATSQQQQQQPQQQSGQLQLSSVPFSVSPS 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	6/27 (22%)
		MBT	929..1028	CDD:214723
		MBT	1038..1130	CDD:214723
		SAM_PNT	1279..1366	CDD:280377
ph-d	NP_524794.2	SAM_Ph1,2,3	1461..1529	CDD:188976
ph-d	NP_524794.2	SAM	1464..1529	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453492
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840