DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)mbt and l3mbtl3

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001232893.1	Gene:	l3mbtl3 / 403075	ZFINID:	ZDB-GENE-040724-127	Length:	523	Species:	Danio rerio

Alignment Length:	498	Identity:	189/498 - (37%)
Similarity:	269/498 - (54%)	Gaps:	55/498 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   676 LQNSTVRFELNEFNFLQ-INERCQPRQGPAAY----FERPL------------YDRP-GRRPSAC 722
            |..|.::|.:|||..|: |.|..:..:|..|:    :..|.            .|.| |:|...|
Zfish    28 LPGSELKFRVNEFGVLEVITEEMEEERGKKAHATTTWSVPTAQEALSEGSVLKQDSPWGQRGLVC 92

  Fly   723 VHPLLYLCQRCNFHGPAADFLAPHF-CSVGCVRRSQKRRLPQSTQKESKI---SRTQLEQTA--- 780
            |        |||..|.|.|||.... ||..|:::.|:....:.::...::   .||:||::|
Zfish    93 V--------RCNRKGSAVDFLPDGLHCSERCLQQEQEELKTEGSRMNGELLSRKRTRLERSAEDM 149

  Fly   781 GTAPDLPQKRQTNYKPHKSLSAIQEQLQQRQKDK--------------PRKPFRWSEYLKSKGKD 831
            .::.|:|::...:|:..:|....:...:.|:|.:              .:|.:.|:.||:.: :.
Zfish   150 DSSMDIPEEEDEDYEEKESRRPARGATRGRKKRRGDAALLRYTVPYGGKKKAWCWASYLEQE-RA 213

  Fly   832 VAAPIHLF--LNPFPISPNCFEIGMKLEAIDPENCSLFCVCSIVEVRGYRLKLSFDGYSSMYDFW 894
            :|||..||  ...||...|.|.:||:||.||||:.|::||.:|.||.|:|::|.||.:|..||||
Zfish   214 IAAPSKLFKEYQCFPQCKNGFRVGMRLEGIDPEHPSMYCVLTIAEVSGHRIRLHFDHFSDCYDFW 278

  Fly   895 VNADSQDIFPPGWCDETARVLQAPKDYNSERFSWSRYLVKTGGKAAPRALFGHLNMQQQMDVRNG 959
            ||::|.||.|.|||::|...|..||....|.||||.|:.....:.||:|||.:.||..   ..:|
Zfish   279 VNSNSPDIHPVGWCEKTGHKLHPPKGMKDEEFSWSSYIKLNKIQTAPKALFHNQNMTV---TPSG 340

  Fly   960 FAVGMHLEAEDLNDTGKICVATVTDILDERIRVHFDGWDDCYDLWVHITSPYIHPCGW-HEGRQQ 1023
            |.|||.|||....|...||||||||::|.|..||||.|::.||.|...|||||||.|| .|..:.
Zfish   341 FRVGMKLEAVCRKDPTFICVATVTDMVDSRFLVHFDNWEESYDYWCDATSPYIHPVGWCQENGRT 405

  Fly  1024 LIVPPDY-QKSAFIWDDYISEVGGMAASKELFTPRQPMEYQERMKLEVVDQRNPCLIRPATVVTR 1087
            |..||.| ..:.|.|:.|::|...:.|....|..:.|..:|..|||||||:|||.|||.|||...
Zfish   406 LSTPPGYPDANNFSWEKYLAETSSLPAPARAFKVKPPHGFQVNMKLEVVDKRNPVLIRVATVADT 470

  Fly  1088 KGYRVQLHLDCWPTEYYFWLEDDSPDLHPIGWCEATSHELETP 1130
            ..:|:.:|.|.|..||.:|::.||||:||.|||..|.|.|:.|
Zfish   471 DDHRLWIHFDGWTDEYDYWIDADSPDVHPAGWCAKTGHPLQPP 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	46/97 (47%)
		MBT	929..1028	CDD:214723	47/99 (47%)
		MBT	1038..1130	CDD:214723	41/91 (45%)
		SAM_PNT	1279..1366	CDD:280377
l3mbtl3	NP_001232893.1	MBT	206..302	CDD:214723	46/96 (48%)
		MBT	313..409	CDD:214723	47/98 (48%)
		MBT	421..513	CDD:214723	41/91 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583951
Domainoid	1	1.000	93	1.000	Domainoid score	I7503
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002225
OrthoInspector	1	1.000	-	-		otm26339
orthoMCL	1	0.900	-	-		OOG6_104389
Panther	1	1.100	-	-	O	PTHR12247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1471
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.840