DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)mbt and Scmh1

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_038966228.1	Gene:	Scmh1 / 362581	RGDID:	1305788	Length:	718	Species:	Rattus norvegicus

Alignment Length:	715	Identity:	166/715 - (23%)
Similarity:	247/715 - (34%)	Gaps:	218/715 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   795 KP---HKSLSAIQEQLQQRQKDKPRKP--------FRWSEYLKSKGKDVAAPIHLFLNPFPISPN 848
            ||   |.|.||.|.|          :|        |.|.:||| :...|.||:|.|...:....|
  Rat    57 KPKYGHLSESASQYQ----------EPVDILELGHFTWDKYLK-ETSSVPAPVHCFKQSYTPPSN 110

  Fly   849 CFEIGMKLEAIDPENCSLFCVCSIVEVRGYRLKLSFDGYSSMYDFWVNADSQDIFPPGWCDETAR 913
            .|:|.|||||.||.|.:..|:.::|.:.|.||:|..||..:..|||...||.:|.|.|.|::...
  Rat   111 EFKISMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSSEIQPIGNCEKNGG 175

  Fly   914 VLQAPKDYNSERFSWSRYLVKT--GGKAAPRALFGHLNMQQQMDVRNGFAVGMHLEAEDLNDTGK 976
            :||.|..:.....||..:|:||  |.:.||..:|   :.:......|.|.:||.|||.|..:...
  Rat   176 MLQPPLGFRLNASSWPMFLLKTLNGAEMAPIKIF---HKEPPSPSHNFFKMGMKLEAVDRKNPHF 237

  Fly   977 ICVATVTDILDERIRVHFDGWDDCYDLWVHITSPYIHPCGW--------HEGRQQLIVP------ 1027
            ||.||:.::....:.|.||||...:|.|....|..|.|.||        .....::::|
  Rat   238 ICPATIGEVRGSEVLVTFDGWRGAFDYWCRFDSRDIFPVGWCSLTGDNLQPPGTKVVIPKNPSPS 302

  Fly  1028 -------PDYQKSAFIWDDYISEVGGMAASKELFTPR--------------QPMEYQERMKLEVV 1071
                   |....:..:.:....:.|.....|...||:              :|:::.::...:..
  Rat   303 SDVSTEKPSINSTKTVLEPQPGQRGRKPGKKRGRTPKILIPHPTSTPSKSAEPLKFPKKRGPKPG 367

  Fly  1072 DQRNP--CLIRPATVVTRKGYRVQLHLDCWPTEYYFWLEDDSPDLHPIGWCEATSHELETPPGYL 1134
            .:|.|  .|..|.|..|                    .....||...:....||     .|...:
  Rat   368 SKRRPRTLLSPPPTSPT--------------------TSTPEPDTSTVPQDAAT-----IPSSAM 407

  Fly  1135 QPKSVMPC---DVEGCRG--------------FGNAKRFNLNVHALREC--CPYAPENWRQWRSK 1180
            |..:|  |   :..|..|              ||.|:...:...|::.|  |.|        ..|
  Rat   408 QAPTV--CIYLNKSGSTGPHLDKKKIQQLPDHFGPARASVVLQQAVQACIDCAY--------HQK 462

  Fly  1181 TVKPPRVAPENIRRGWAKKTKRACSEAKQAIKEDSQQEIVYPKVAEVVQAKR------------- 1232
            ||.      ..:::|..       .|...|:.:..|..:..|.|..:....|
  Rat   463 TVF------SFLKQGHG-------GEVISAVFDREQHTLNLPAVNSITYVLRFLEKLCHNLRSDN 514

  Fly  1233 --KTSPCEEKVVKKQKQMQKEEDAEQVPDE---------RSLAIARSFVKDYG--PQFL------ 1278
              ...|..:..|..............:|.|         |||. ..|.:.|..  |..|
  Rat   515 LFGNQPFTQTHVSLTATEYSHGHDRYLPGETFVLGNSLTRSLE-THSDLMDSALKPANLVSTSQT 578

  Fly  1279 ---PNYR------------------------------------LWQLNSA-------FKLDDVR- 1296
               |.||                                    .|:||.:       ...|..|
  Rat   579 LRTPGYRPLLPSCGLPLSTVSAVRRLCSRGVLKGTRERRDVESFWKLNHSPGSDRHLESRDPPRL 643

  Fly  1297 --TNPLHWTSWDVCEYIERA---LDSTDIAKVIFEQDIDGRALLMLGRKELDTYLKLKVGPAVKL 1356
              .:|..||..||.:::..|   |.|.  |.:..:.:|||:|||:|....:..|:.||:|||:||
  Rat   644 SGRDPSSWTVEDVMQFVREADPQLGSH--ADLFRKHEIDGKALLLLRSDMMMKYMGLKLGPALKL 706

Fly 1357 1356
Rat 707 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	38/95 (40%)
		MBT	929..1028	CDD:214723	32/121 (26%)
		MBT	1038..1130	CDD:214723	15/107 (14%)
		SAM_PNT	1279..1366	CDD:280377	32/127 (25%)
Scmh1	XP_038966228.1	MBT	85..180	CDD:214723	38/95 (40%)
		MBT	191..289	CDD:214723	31/100 (31%)
		RBR	324..373	CDD:407329	6/48 (13%)
		SLED	411..519	CDD:403384	21/130 (16%)
		SAM_Scm	645..715	CDD:188977	24/64 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343700
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840