Protein Alignment l(3)mbt and Sfmbt2

DIOPT Version :10

• Sequence 1: NP_733209.1
• Gene: l(3)mbt / 43288
• FlyBaseID: FBgn0002441
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: NP_001185737.1
• Gene: Sfmbt2 / 353282
• MGIID: 2447794
• Length: 975
• Species: Mus musculus
• Alignment Length: 1010
• Identity: 197/1010 - (19%)
• Similarity: 309/1010 - (30%)
• Gaps: 430/1010 - (42%)

  Fly   758 KRRLPQSTQKESKISRTQLEQTAGTAPDLPQKRQTNYKPHKSLSAIQEQLQQRQKDKPRKPFRWS 822
            :|.||.|.::.|..|   ||:..|:|    ....|.|.        :|.....:.|     |.|.
Mouse     2 ERYLPVSKKRNSSSS---LEKITGSA----NGNGTLYS--------EEDTNLEEND-----FSWG 46

  Fly   823 EYLKSKGKDVAAPIHLFLNPFPIS-PNCFEIGMKLEAIDPENCSLFCVCSIVEVRGYRLKLSFDG 886
            :||:..|.. |.| |:......|| .:.|:.|||||..:..|...:.|.:|:...|..|.|.:.|
Mouse    47 DYLEETGTR-AVP-HVSFRHVEISIRSNFQPGMKLEVANKNNPDTYWVATIITTCGQLLLLRYCG 109

  Fly   887 YSS--MYDFWVNADSQDIFPPGWCDETARVLQAPKDYNSERFSWSRYLVK--TGGKAAPRALF-G 946
            |..  ..|||.:....|:.|.|||.:..:||:.|.....:...|:.:|::  ||.:.||..|. |
Mouse   110 YGEDRRADFWCDVIIADLHPVGWCTQNNKVLRPPDAIKDKYSDWTDFLIRELTGSRTAPANLLEG 174

  Fly   947 HLNMQQQMDVRNGFAVGMHLEAEDLNDTGKICVATVTDILDERIRVHFDGWD--DCYDLWVHITS 1009
            .|..:..:|:   ..|...:|.:|..:..:..:.:||:.:..|:|:.:.|.:  :.||.|:....
Mouse   175 PLRGKGPIDL---ITVDSLIELQDSQNPFQYWIVSVTENVGGRLRLRYVGLEHTESYDRWLFYLD 236

  Fly  1010 PYIHPCGWHEGRQQLIVPPD---YQKSAFIWDDYISEVGGMAASKEL---------------FT- 1055
            ..:.|.||.:..:..:.||.   |.|..|.|...:.:...:||...|               ||
Mouse   237 YRLRPIGWCQENKYRMDPPSELYYLKLPFEWKCALEKALVLAAESPLPMEVFKDHADLQSHFFTV 301

  Fly  1056 ----------------------------------------------------------------- 1055
                                                                             
Mouse   302 GMRLETLHISDPFHIYPASVTKVFNSKFFQVAIDDLRPEADKPTMLCHADSLGILPVQWCLKNGV 366

  Fly  1056 --------------------PRQPME-------------YQERMKLEVVDQRNPCLIRPATVVTR 1087
                                .||..|             :.:.||||.|:..||..:..||||:.
Mouse   367 NLAPPKGYSGQDFNWVDYHKQRQAEEAPHFCFKNAFSRGFSKNMKLEAVNPVNPGEVCVATVVSV 431

  Fly  1088 KGYRVQLHLDCWPTEYYFWLED-DSPDLHPIGWCEATSHELETP-----------------PGYL 1134
            ||..:.|||:...|.....:.| ||.|:.|:|||||.|:.|.||                 ...|
Mouse   432 KGRLLWLHLEGLETPMPDIIVDMDSMDIFPVGWCEANSYPLTTPYKASSKSKRKTVHFKMEKQLL 496

  Fly  1135 QPKSV---------MPCDVEGCRGFGNAKRFNLNVHALRECCPYAPENWR--------------- 1175
            .|..:         :|..::...|..|||          .|||....|.|
Mouse   497 SPVPIEKIPHELCLLPPQMDSPVGAINAK----------YCCPQLFVNHRCFSGPFLNKGRISEL 551

  Fly  1176 ----------------------------------------QWRSK---------------TVKPP 1185
                                                    :|.|:               .||..
Mouse   552 PQSVGPGMCVLVLKEILTLITNAAYKPGRVLRELQLVEDPEWNSQEEILKAKYGGKTYRAVVKIV 616

  Fly  1186 RVA------------------------------PEN----IRRGWAKKTKRACSEAKQAIKEDS- 1215
            |.|                              |||    .:..:.|:.|.:.......:|:||
Mouse   617 RTADQVMNFCRQVCAKLECCPNLLSPVLISETCPENCSVHTKTRYNKREKGSSLSPASELKDDSA 681

  Fly  1216 -----------QQEIVYPKVAEVVQAKRKTSPCE--EKVVKKQKQ-----MQKE----------- 1251
                       .|...|.|...|:|:..:.|..|  .|..:::|:     :||.
Mouse   682 SHATKLQKAKIPQTYYYGKRRRVIQSSLRVSNIETPPKSTRRRKRRKSVYVQKRRKSAIVVPAGV 746

  Fly  1252 ---------ED---------------------AEQVPDERSLAIARSFVKD-------------- 1272
                     ||                     .|.:|:....||..|..|.
Mouse   747 PAGVPAGVPEDIPAGIPEGIPASIPESIPEGIPESLPESLPEAIPESIPKGSAQKTEQEKRETLD 811

  Fly  1273 --------YGPQFL--------------------------------------------------- 1278
                    :||.:.
Mouse   812 TARKKTGYHGPAYQTDTSAAQVPFARPRRAVTLRRNSEALKRPPVERARRVRTVPTTASSNNRVK 876

  Fly  1279 -PNYRLWQLNSAFKLDD----VRTNPLHWTSWDVCEYIERALDSTDIAKVIFEQDIDGRALLMLG 1338
             |..|:.:...:.:.|:    :.:|||.|:..||..:| :..|...:|::..||||||:|||:|.
Mouse   877 GPLVRIVKPEDSSQSDEEKLILESNPLEWSVTDVVRFI-KLTDCAPLARIFQEQDIDGQALLLLT 940

  Fly  1339 RKELDTYLKLKVGPAVKLYSLILNLRIAVVCKFDS 1373
            ...:...::||:|||:||...|..:::|...::.|
Mouse   941 LPTVQECMELKLGPAIKLCHQIERVKVAFYAQYAS 975

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	PRK10819	<332..>427	CDD:236768
		MBT_L3MBTL1-like_rpt1	846..945	CDD:439091	32/103 (31%)
		MBT_L3MBTL1-like_rpt2	957..1045	CDD:439092	20/92 (22%)
		MBT_L3MBTL1-like_rpt3	1058..1130	CDD:439093	31/85 (36%)
		SAM_PNT	1278..1367	CDD:460486	30/144 (21%)
Sfmbt2	NP_001185737.1	MBT_SFMBT2_rpt1	70..163	CDD:439102	27/92 (29%)
		MBT	182..279	CDD:459242	21/99 (21%)
		MBT_SFMBT2_rpt3	297..389	CDD:439106	2/91 (2%)
		MBT_SFMBT2_rpt4	405..495	CDD:439108	31/89 (35%)
		SLED	528..643	CDD:463469	10/114 (9%)
		SAM_Scm-like-4MBT1,2	893..975	CDD:188980	28/82 (34%)