DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)mbt and Sfmbt

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001137821.1	Gene:	Sfmbt / 34709	FlyBaseID:	FBgn0032475	Length:	1243	Species:	Drosophila melanogaster

Alignment Length:	1221	Identity:	249/1221 - (20%)
Similarity:	409/1221 - (33%)	Gaps:	442/1221 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   468 AIETITIED-----------DDESEEEQQKPEI-------------------------KKTPKQN 496
            |:|.:..:|           ||...|.:.|.||                         .|...|:
  Fly   130 AMEAVVDDDDQVYGQRDNNFDDNGSELEPKQEIINIDDFVMMNEDNNSYDGTDFMTSSDKDISQS 194

  Fly   497 ------QKPEKQEAPKKKQ---IPMP------------ILPA----------GITISTTSTAKKK 530
                  |.|.....|..:.   :|:|            ::||          .|.:||.:|:.|:
  Fly   195 SSSCMAQMPGSLGVPGVEHDLLVPLPDGLLHHKLLGTTLVPAMGTLNGNAFGNIMVSTENTSSKQ 259

  Fly   531 AVR-------KNSSVTTISSSSSDSSSYSDVEVVPTKKTEK-ELSMLPGISI---------IKAE 578
            ..|       .||:.||.:.|:|.||:...     .:||.| |....||:.:         |...
  Fly   260 MQRTYSTAKGANSTATTATCSASTSSALRS-----QRKTRKIEPVNRPGLVLKTPIAYRGNIDPS 319

  Fly   579 SLPLSREDFERSLRCDE-QVPQT-PPKS----SSSSSSGSHASEMSPPPKLADPKPSSPPAKNAK 637
            .:|:.::......||.. .|..| ..||    |.:.:.|...|.:.......|...:|.|
  Fly   320 VIPIQKDGMAVCKRCGAIGVKHTFYTKSRRFCSMACARGELYSLVLNTKMEGDQATTSSP----- 379

  Fly   638 KANDHDANPSPSSKTNDFKKSMMQNLNMLKWRGQQPANLQNSTVRFEL-NEFNFLQINERCQPRQ 701
                   :|...|::.|......|:.:.:: .....|:::|:..||.: ::....|:|...:|..
  Fly   380 -------DPGAGSESADLPGDQQQSQSDIE-LDLHAAHIKNANYRFRITDQSKITQLNSFGEPMS 436

  Fly   702 --GPAAYFERPLYDRPGRRPSACVHPLLYLCQRCNFHGPAAD--FLAPHFCSVGCVRRSQKRRLP 762
              |.||                           .|....|||  ..|.:..:||      ....|
  Fly   437 MGGDAA---------------------------ANNVQMAADETIAALNGGAVG------DATAP 468

  Fly   763 QSTQKESKISRTQLEQTAGTAP-------------DLPQKRQTNYKP------HKSLSAIQEQLQ 808
            .||::.:....:.|  :|...|             ||||..:....|      .|.:|     ::
  Fly   469 GSTEEGASTPNSYL--SAAPTPKALRLFKDIYPQDDLPQIPKYERLPVPCPQMEKIIS-----IR 526

  Fly   809 QRQKDKPRKPFRWSEYLKSKGKDVAAPIHLFLNPFPISPNC-----FEIGMK----------LEA 858
            :|..| |...:.|...| ||....|||:    ..||.:|.|     ..:|||          :|.
  Fly   527 RRMYD-PTHSYDWLPRL-SKENFNAAPV----TCFPHAPGCEVWDNLGVGMKVEVENTDCDSIEV 585

  Fly   859 IDP-ENCSLFCVCSIVEVRGYRLKLSFDGY-SSMYDFWVNADSQDIFPPGWCDETARVLQAPKDY 921
            |.| :..:.|.|.:|:|::||:..:|::|: :..:|||||..:.::...|||....:.|..|:..
  Fly   586 IQPGQTPTSFWVATILEIKGYKALMSYEGFDTDSHDFWVNLCNAEVHSVGWCATRGKPLIPPRTI 650

  Fly   922 NSERFSWSRYLV--KTGGKAAPRALFGHLNMQQQMDVRNGFAVGMHLEAEDLNDTGKICVATVTD 984
            ..:...|..:||  .:|.:..|...:..:|...|    :.|.:|::||..|.:...::.:||||.
  Fly   651 EHKYKDWKDFLVGRLSGARTLPSNFYNKINDSLQ----SRFRLGLNLECVDKDRISQVRLATVTK 711

  Fly   985 ILDERIRVHFDGWDDCYDLWVHITSPYIHPCGW-----HE-------------GRQQLI------ 1025
            |:.:|:.:.:...||.:  |.|..||.|||.||     |.             ||:.:|
  Fly   712 IVGKRLFLRYFDSDDGF--WCHEDSPIIHPVGWATTVGHNLAAPQDYLERMLAGREAMIEVHEDD 774

  Fly  1026 ----------------------------------------------------------------- 1025

  Fly   775 ATIELFKMNFTFDEYYSDGKTNSFVEGMKLEAVDPLNLSSICPATVMAVLKFGYMMIRIDSYQPD 839

  Fly  1026 -----------------------------VPPD-YQKSAFIWDDYISEVGGMAASKELFTPRQPM 1060
                                         .||: |....|.|:.|:.:.|.:||.:.||....|.
  Fly   840 ASGSDWFCYHEKSPCIFPAGFCSVNNISVTPPNGYDSRTFTWEGYLRDTGAVAAGQHLFHRIIPD 904

  Fly  1061 E-YQERMKLEVVDQRNPCLIRPATVVTRKGYRVQLHLDCWPTEYYFWLEDDSPDLHPIGWCEATS 1124
            . ::..|.||..|..:|.|:..|||....|..:::|.|.|..||..||:.:|.|::|:|||...:
  Fly   905 HGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWLDCESADIYPVGWCVLVN 969

  Fly  1125 HELETPPGYLQPKSVMPCDVEGCRGFGNAKRFNLNVHALRECCPYAPENWRQWRSKTVKPPRVAP 1189
            |:||.||                                              |....:.|:.||
  Fly   970 HKLEGPP----------------------------------------------RVAHQQAPKPAP 988

  Fly  1190 E-NIRRGWAKKTKRACSEAK-------QAIKEDSQQEIVYPKVAEVVQAKRKTSPCEEKVVKKQK 1246
            : .|:|  .:|.|:..:..|       |::|..:......|.:.: :..|.:..|........:.
  Fly   989 KPKIQR--KRKPKKGAAGGKTPTDNNTQSVKSRTIALKTTPHLPK-LSIKLELKPEHHNAAFYEN 1050

  Fly  1247 QMQKEEDAEQVPD-------------ERSL-----------------------------AIARSF 1269
            ...:||..|:.||             |:|.                             .:.:|.
  Fly  1051 NQPEEEGDEEDPDADGDGDGSTSHISEQSTTQSSSDLIAGSGSGSGSASLVTLATGSNKTVKKST 1115

  Fly  1270 VKDYGP--------QFLPNYRLWQLNSAFKLDDVRTNPLH-------WTSWDVCEYIERALDSTD 1319
            .|...|        .::.|..........:|.|:.::..|       |..:||.::: |..|.|.
  Fly  1116 TKSPAPPTVGRKATSYIANSSATNNKYIPRLADIDSSEPHLELVPDTWNVYDVSQFL-RVNDCTA 1179

  Fly  1320 IAKVIFEQDIDGRALLMLGRKELDTYLKLKVGPAVKLYSLILNLRIAVVCK 1370
            .........|||:.||.|.:.::...|.:|||||:|:..||..|:    ||
  Fly  1180 HCDTFSRNKIDGKRLLQLTKDDIMPLLGMKVGPALKISDLIAQLK----CK 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	33/112 (29%)
		MBT	929..1028	CDD:214723	32/218 (15%)
		MBT	1038..1130	CDD:214723	33/92 (36%)
		SAM_PNT	1279..1366	CDD:280377	26/93 (28%)
Sfmbt	NP_001137821.1	MBT	542..647	CDD:214723	33/109 (30%)
		MBT	658..753	CDD:214723	29/100 (29%)
		MBT	767..871	CDD:214723	1/103 (1%)
		MBT	882..975	CDD:214723	33/92 (36%)
		TonB_N	<975..1040	CDD:292650	15/113 (13%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979	22/70 (31%)
		SAM	1160..1224	CDD:197735	21/64 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453494
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840