DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)mbt and Samuel

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001260372.1	Gene:	Samuel / 34530	FlyBaseID:	FBgn0032330	Length:	968	Species:	Drosophila melanogaster

Alignment Length:	585	Identity:	119/585 - (20%)
Similarity:	197/585 - (33%)	Gaps:	165/585 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SPSTANCNGVASASGGNPNPNSLLTLAPRKEELRFLP-LAPMGGNKTCNITISNVQPMKSKLKSV 94
            :||:::..|....:||..:|:.......:::.|:... |:|..|......|.:      |.|.|.
  Fly   275 TPSSSSYRGAGGGAGGGVSPSHQQQQQQQQQSLQQQQRLSPPSGPSMATATTT------SSLSSS 333

  Fly    95 NIVPNSIKSAGAGAT--------------VGSADAPLFQLVPSPSNPSQPLVAILAPNRKTTLLG 145
            :....|..::.:.||              :..|.|...||..|.||.|.   .|...:..|...|
  Fly   334 SSASASASASASAATHMPLHNLSTNLLNSIQQAAASQQQLRSSNSNSSS---NISGSSNNTKSDG 395

  Fly   146 GGASNGQPVVIRSGTPL-------------HKNSLTVETSNKPIQPGGSAAAAAVGGGTGGAPLT 197
            |.|||......|:.:.:             :.|:.|...|........:.|....|||.|||.
  Fly   396 GAASNATDFSTRNYSDIMRCLAAKYNNANPNDNNATRRNSYYDGSTSATTATGGAGGGGGGAG-- 458

  Fly   198 LVGKTVVPPKIQAATPVQIPSTGPGAQVSLLANPLKPRAPLILSKVAVDKLRLKFSQVKSNPNAL 262
              |....|   .:|......|||   ..:..|..|.|.|....:..||.
  Fly   459 --GSNSAP---SSALKTASSSTG---STTTTAKKLSPSAASAANSAAVS---------------- 499

  Fly   263 VLGKANHVKKLLTSPNPSGEDKTRSTQKNNKQNTSASQLKPVVAPKTAMPIATEVPTADNNKMSL 327
             |.|.:.|..:      .|.....:...:....:|.|||.|   |.|| |..||
  Fly   500 -LSKESKVSAV------GGAGVGGAVASSGGGGSSMSQLAP---PPTA-PSPTE----------- 542

  Fly   328 IKSKPVAIKAVPLPSQEAPIVPA--VAPVVTS---------PEKVDVKPTAKPSIKTAPKPTPKP 381
             ::|          ||.|.:|.|  |:|.:|:         |..:|:..|  .::.|..:..
  Fly   543 -QAK----------SQMAAVVAAASVSPFMTNFLPFSSGIFPPLIDMSST--QALLTLARAV--- 591

  Fly   382 LEMSVNGPAKEKKAPAKEQKQKTMDKPPVVKEIAQHTPCGPKELPKLKRSKSFVSNHPASPVANN 446
                                     |...::||.:         .|.:||.|..|: |::..|..
  Fly   592 -------------------------KDAEIQEILR---------SKQQRSGSNASS-PSASAAGT 621

  Fly   447 ERRHSVAIMAKEVDVIEQPSAAIETITIEDDDESEEEQQKPEIKKTPKQNQKPEKQEAPKKKQIP 511
            .|..|....|..........|.|.:..::   :.:::||:...::..:|:|...:|.:|:.....
  Fly   622 PRSSSTLNAALHQAAQFVTPALIYSAQLQ---QQQQQQQQQHQRQQQQQSQHASRQSSPRSTNDS 683

  Fly   512 MPILPAG-------------ITISTTSTAKK--KAVRKNSSVTTISSSSSDSSSYSDVEVVPTKK 561
            ..:.|.|             :.:|:...|.|  ||.|:.||..|.:::::..||.|.....|.::
  Fly   684 TTVAPIGDGGGGSSIASAAPLDLSSQPPAAKRFKAERRASSTATTATTATTGSSTSTPSPPPLEQ 748

Fly 562 561
Fly 749 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723
		MBT	929..1028	CDD:214723
		MBT	1038..1130	CDD:214723
		SAM_PNT	1279..1366	CDD:280377
Samuel	NP_001260372.1	SAM_Samd7,11	795..862	CDD:188978
Samuel	NP_001260372.1	SAM	795..852	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910