DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)mbt and SAMD7

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001291295.1	Gene:	SAMD7 / 344658	HGNCID:	25394	Length:	446	Species:	Homo sapiens

Alignment Length:	455	Identity:	92/455 - (20%)
Similarity:	147/455 - (32%)	Gaps:	152/455 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1006 HITSPYIHPCGWHEGRQQLIVPPDYQKSAFIWDDYISEVGGMAASKELF----TPRQPME----Y 1062
            ::.|..|:| ||.      |:||:             .:..:|...|:.    |.|..||    |
Human    62 NVLSSRIYP-GWG------ILPPE-------------SIKAVARRNEMIQRHHTARTEMEMYAIY 106

  Fly  1063 QERMKLEVVDQRN------PCLIRPATVVTRKGYRVQLHLDCWPTEYYFWLEDDSPDLHPIGWCE 1121
            |:| ::|.::.:.      |.|...:.......|..:..|             .:.|||   :..
Human   107 QQR-RMEKINPKGLAGLGIPFLYGSSVPAAPAAYHGRSML-------------PAGDLH---FHR 154

  Fly  1122 ATSHELE-------TPPGYLQP--------------KSVMPCDVEGCRGFGNAKRFNLNVHALRE 1165
            :|...|:       |.|.:.:.              :..:..|.|..:.....|... ..||:
Human   155 STLRNLQGNPMLAATAPHFEESWGQRCRRLRKNTGNQKALDSDAESSKSQAEEKILG-QTHAV-- 216

  Fly  1166 CCPY------------APENWRQWRSKTVKPPRVAPENI--------RRGWAKKTKRACSEAKQA 1210
              ||            ||.|  |..|:|.:.|..|..|.        |:.|...|....::|...
Human   217 --PYEEDHYAKDPDIEAPSN--QKSSETNEKPTTALANTCGELEPTHRKPWGSHTTTLKAKAWDD 277

  Fly  1211 IKEDSQQEIVYPKVAEVVQAKRKTSPCEEKVVKKQKQMQKEEDAEQVPDERSLAIARSFVKDYGP 1275
            .||::.::|.              :.|:|          |......||               .|
Human   278 GKEEASEQIF--------------ATCDE----------KNGVCPPVP---------------RP 303

  Fly  1276 QFLPNYRLWQLNSAFKLD-DVRTNPLHWTSWDVCEYIERALDSTDIAKVIFEQDIDGRALLMLGR 1339
            .....:.|..:.....|| |::    .||..||..:|......:|.|:|..:..|||..|.:|..
Human   304 SLPGTHALVTIGGNLSLDEDIQ----KWTVDDVHSFIRSLPGCSDYAQVFKDHAIDGETLPLLTE 364

  Fly  1340 KELDTYLKLKVGPAVKLYSLILNLRIAVVCKFDSKNIELESNTAGPIQREMDTPVSAIKQLPEQS 1404
            :.|...:.||:|||:|:.|.:..   .|...|..|.:..      ||::..|.|......|...|
Human   365 EHLRGTMGLKLGPALKIQSQVSQ---HVGSMFYKKTLSF------PIRQAFDQPADTSPLLDPNS 420

Fly 1405 1404
Human 421 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723
		MBT	929..1028	CDD:214723	6/21 (29%)
		MBT	1038..1130	CDD:214723	19/112 (17%)
		SAM_PNT	1279..1366	CDD:280377	25/87 (29%)
SAMD7	NP_001291295.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..207		2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..277		13/53 (25%)
		SAM_Samd7,11	324..391	CDD:188978	22/73 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149797
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840