DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)mbt and L3mbtl4

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_796252.2	Gene:	L3mbtl4 / 320858	MGIID:	2444889	Length:	621	Species:	Mus musculus

Alignment Length:	633	Identity:	210/633 - (33%)
Similarity:	306/633 - (48%)	Gaps:	87/633 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   790 RQTNYKPHKSLSAIQEQLQQR---QKDKPRKP------------------FRWSEYLKSKGKDVA 833
            ||.|.|...||.:.:...|.|   |.::.:||                  :.|.:||: :|..||
Mouse     2 RQPNRKRKLSLESTERMNQDRCTGQTEEEKKPGEVTTPSKRESSVTTAETWSWEQYLR-EGNAVA 65

  Fly   834 APIHLFL--NPFPISPNCFEIGMKLEAIDPENCSLFCVCSIVEVRGYRLKLSFDGYSSMYDFWVN 896
            ||:.||.  ..||...|.|::||:||.||....|:|||.|:.||.||||:|.||||.|.||||.|
Mouse    66 APVELFSKDQSFPEHENGFQVGMRLEGIDARRPSVFCVLSVAEVCGYRLRLHFDGYLSCYDFWTN 130

  Fly   897 ADSQDIFPPGWCDETARVLQAPKDYNSERFSWSRYLVKTGGKAAPRALFGHLNMQQQMDVRNGFA 961
            |.|.||.|.|||.:|...|..|:||..::|.|..||.....:.||:.||  .|......|...|.
Mouse   131 AGSPDIHPVGWCQKTKHELHIPRDYRKDKFVWMDYLKACRLQNAPKKLF--RNRSSNGPVPREFQ 193

  Fly   962 VGMHLEAEDLNDTGKICVATVTDILDERIRVHFDGWDDCYDLWVHITSPYIHPCGW-HEGRQQLI 1025
            |||.|||.|..:...:||||:.||:::|:|||||..||.:|.|..:.||||.|.|| .|..:.|:
Mouse   194 VGMKLEAVDRRNPCLMCVATIADIVEDRVRVHFDSLDDSFDYWCDVNSPYIQPVGWCQENGRTLV 258

  Fly  1026 VPPDY-QKSAFIWDDYISEVGGMAASKELFTPRQPMEYQERMKLEVVDQRNPCLIRPATVVTRKG 1089
            .|..| ....|.|.||:......|...:.|..|.|..:...||||.||:|||.|||.||:.....
Mouse   259 APQGYPHPDKFSWTDYLRASQSKAVPAKAFGMRTPHGFLPNMKLEAVDKRNPQLIRVATIADVDD 323

  Fly  1090 YRVQLHLDCWPTEYYFWLEDDSPDLHPIGWCEATSHELETPPGYLQPKSVMP----CDVEGCRGF 1150
            |||::|.|.|..:|.:|::.||.|:||||||:.|.|.||.|.|....| ::|    |...||||.
Mouse   324 YRVKIHFDGWDHKYDYWVDADSQDIHPIGWCDVTGHPLEVPYGSKHVK-ILPGQPACPTPGCRGI 387

  Fly  1151 GNAKRFNLNVHALRECCPYAPENWR-------QWRSKTVKPPRVAPENIR---------RGWAKK 1199
            |:.:......|.....|||:..|.:       :.|.:|.....:.|.:.:         .|..:.
Mouse   388 GHIRGPRYAGHHSAFGCPYSDVNLKREAALQDRLREQTQANLELDPSHSKSENPCNLNVNGKCEN 452

  Fly  1200 TKRACSEAKQAI------KEDSQQE------IVYPKVAEVVQAKRKTSPCEEKVVKKQKQMQKEE 1252
            ....|...:||.      |||...:      :.:|:..|...|:          |::........
Mouse   453 ANSQCRLVQQAKCLKIKGKEDIDLDNLFRVLVFHPRRLEYSAAQ----------VQQMLHQPLSM 507

  Fly  1253 DAEQVPDERSLAIARSFVKDYGPQFLPNYRLWQLNSAFKLDDVRTNPL-HWTSWDVCEYIERALD 1316
            .:......|.:.::|    :...:.||.           :.|::.:.: .||..:|.|:::..|.
Mouse   508 TSTSAHPFRDIPLSR----EQHCKLLPG-----------VADIQASQVARWTVDEVAEFVQSLLG 557

  Fly  1317 STDIAKVIFEQDIDGRALLMLGRKELDTYLKLKVGPAVKLYSLILNLR 1364
            ..:.||...::.|||:|.|:|.:.::...:::|:|||:|:|:.||..|
Mouse   558 CEEHAKCFKKEQIDGKAFLLLTQADIVKVMRIKLGPALKIYNSILMFR 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	51/97 (53%)
		MBT	929..1028	CDD:214723	41/99 (41%)
		MBT	1038..1130	CDD:214723	41/91 (45%)
		SAM_PNT	1279..1366	CDD:280377	24/87 (28%)
L3mbtl4	NP_796252.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48		11/45 (24%)
		MBT 1	52..152		52/100 (52%)
		MBT	55..149	CDD:214723	50/94 (53%)
		MBT 2	160..260		43/101 (43%)
		MBT	164..260	CDD:214723	41/97 (42%)
		MBT 3	269..364		43/94 (46%)
		MBT	273..364	CDD:214723	41/90 (46%)
		zf-C2HC	379..405	CDD:279824	7/25 (28%)
		SAM	540..607	CDD:197735	22/66 (33%)
		SAM_Scm-like-3MBT3,4	540..605	CDD:188981	21/64 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839876
Domainoid	1	1.000	96	1.000	Domainoid score	I7303
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002225
OrthoInspector	1	1.000	-	-		otm43427
orthoMCL	1	0.900	-	-		OOG6_104389
Panther	1	1.100	-	-	LDO	PTHR12247
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5341
SonicParanoid	1	1.000	-	-		X1471
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.870