DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)mbt and Phc2

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001013187.2	Gene:	Phc2 / 313038	RGDID:	1307912	Length:	850	Species:	Rattus norvegicus

Alignment Length:	752	Identity:	161/752 - (21%)
Similarity:	261/752 - (34%)	Gaps:	250/752 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SMASAEAKQLQRNISLSMSPANGGVI----SPSTANCNGVASAS---GGNPNPNSLLTLAP---R 59
            |..|::|.....:::|:.|||...:|    |.::|..:|:|..:   |...:|....:.|.   |
  Rat   125 SSVSSQAPAQSSSLNLAASPAAAQLINRAQSVNSATASGLAQQAVLLGNTSSPALTASQAQMYLR 189

  Fly    60 KEELRFLPLAPMGGNKTCNITISNVQ-----------PMKSKLKSVNIVPNSIKSAGAGATVGSA 113
            .:.|.|.|.|          |::.||           |..::::::.:......:|.|.|....
  Rat   190 AQMLIFTPTA----------TVATVQPELGTGSPARPPTPAQVQNLTLRTQQTPAAAAAAAASG- 243

  Fly   114 DAPLFQLVPSPSNPSQPLVAILAPNRKTTLLGGGASNGQPV-------VIRSGTPLHKNSLTVET 171
                    |:|:.|..|.:|:     |.|     .|:.||:       .:..|:|:.......:.
  Rat   244 --------PAPTQPVLPSLAL-----KPT-----PSSSQPLPPTPQGRTVVQGSPVGAKPSVTDN 290

  Fly   172 SNKPIQPGGSAAAAAVGGGTGGAPLTLVGKTVVPPKIQAATPVQI---PST-GPGAQVSLLANPL 232
            ..:|::..|::...|..|.......|:....:..|......|.|:   ||: .|..|......|.
  Rat   291 VTEPLKTDGNSNMEARPGPDRATVPTVATHQLTAPAYTQLQPHQLLPQPSSKHPQPQFVAQQQPQ 355

  Fly   233 KPR-APLILSKVAVDKLRLKFS-QVKSNPNALVLGKAN----------HVKKLLTS-----PNP- 279
            .|| .|.:.|:..:..:....: |.....:|:.||...          ||.|..:|     |.|
  Rat   356 PPRPTPQVQSQPQLAAVSPSLALQPSPEGHAMPLGPVTQALPLQCSTAHVHKPGSSQQCHLPTPD 420

  Fly   280 SG------EDKTRSTQKNNKQNTSA--SQLKPV------VAP---KTAMPIATEVPTADNNKMSL 327
            ||      |..:.:.|: ..|:|||  .||:|.      .||   |..:|....||.   .:..|
  Rat   421 SGSQNGHPEGVSHAPQR-RFQHTSAVILQLQPASPVPQQCAPDDWKEVVPAEKSVPV---TRPGL 481

  Fly   328 IKSKPVAIKAVP--LPSQEAP-------------IVPAV----APVVTS-------------PEK 360
            ...:...|.|:|  ||..::|             ||.|:    :|.:||             |:.
  Rat   482 SPHQQAIITAIPGGLPGPKSPNIQQCPAHETGQGIVHALTDLSSPGMTSGNGNSASSITGTAPQN 546

  Fly   361 VDVKP---TAKPSIKT----------APKPTPKPLEMSVNGPAKEK--------KAPAKEQKQKT 404
            .:.||   ..||.|.|          ..:|.|......:.|..|:|        |.|.::....|
  Rat   547 GENKPPQAIVKPQILTHVIEGFVIQEGAEPFPVGRSSLLVGNLKKKYAQGFLPEKLPQQDHTTTT 611

  Fly   405 ---MDKPPVVKEIAQHTP-------CGPKELP-KLKRSKSFVSNHPASPVANNERRHSVAIMAKE 458
               |::|.:.:...:.||       ||..:.. |.||||.|.|...|       :|::|. ..|.
  Rat   612 DSEMEEPYLQESKEEGTPLKLKCELCGRVDFAYKFKRSKRFCSMACA-------KRYNVG-CTKR 668

  Fly   459 VDVIEQPSAAIETITIEDDDESEEEQQKPEIKKTPKQNQKPEKQEAPKKKQIPMPILPAGITIST 523
            |.:..             .|.|:.::                                ||.|...
  Rat   669 VGLFH-------------SDRSKLQK--------------------------------AGTTTHN 688

  Fly   524 TSTAKKKAVRKNSSVTTISSSSSDSSSYSDVEVVPTKKTEKELSMLPGISIIKAESLPLSREDFE 588
            ...|.|      :|:.|:                 ||.|:|:.|....:|:..|..|..|:||
  Rat   689 RRRASK------ASLPTL-----------------TKDTKKQPSGTVPLSVTAALQLAHSQED-- 728

  Fly   589 RSLRCDE----QVPQTPPKSSSSSS---SGSHASEMS 618
             |.||.:    :.|.:|..:|||:|   .|....|:|
  Rat   729 -SSRCSDNSSYEEPLSPISASSSTSRRRQGQRDLELS 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723
		MBT	929..1028	CDD:214723
		MBT	1038..1130	CDD:214723
		SAM_PNT	1279..1366	CDD:280377
Phc2	NP_001013187.2	PHC2_SAM_assoc	662..780	CDD:293222	35/175 (20%)
		SAM_Ph1,2,3	781..849	CDD:188976
		SAM	783..850	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343711
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840