DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)mbt and Phc1

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_006237362.1	Gene:	Phc1 / 312690	RGDID:	1309203	Length:	1045	Species:	Rattus norvegicus

Alignment Length:	883	Identity:	188/883 - (21%)
Similarity:	297/883 - (33%)	Gaps:	276/883 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ASAEAKQL----QRNISLSMSPANGGVISPSTANCNGVASASGGNPNPNSLLTLAPRKEELRFLP 67
            |||:..|:    |:.|....||.:|  :|.:::....||.|||.:.               :.|.
  Rat   245 ASAQGPQIPGSTQKAIPPGASPVSG--LSQASSQALAVAQASGASG---------------QSLN 292

  Fly    68 LAPMGGNKTCNITISNVQPMKSKLKSVNIVPNSIKSAGAGATVGSADAPLFQLVPSPSNPSQPLV 132
            |:..||.                  |.|.:|.|:...|.|...|.    |.||      ||..|.
  Rat   293 LSQAGGG------------------SGNSLPGSMGPGGGGQAPGG----LGQL------PSSGLA 329

  Fly   133 AILAPNRKTTLLGGGASNGQPVVIRSGTPLHKNSLTVETSNKPIQPGGSAAAAAVGGGTG----G 193
            ....|.:.|.::       ||:.......:.:.|.|...|        :||..|.|.|:.    |
  Rat   330 GGNCPRKGTGVV-------QPLPAAQTVTVSQGSQTEAES--------AAAKKAEGDGSSQQSVG 379

  Fly   194 APLTLVGKTVVPPK----IQAATPVQIPSTGPGAQVSLLANP----LKPRAPLILSKVAV---DK 247
            ..||   :|..|..    |.:||..||...      ||:...    |:.:..:|..::|:   .:
  Rat   380 MNLT---RTATPAPSQTLISSATYTQIQPH------SLIQQQQQIHLQQKQVVIQQQIAIHHQQQ 435

  Fly   248 LRLKFSQVKSNPNALVLGKANHVKKLLTSPNPSGEDKTRSTQKNNKQNTSASQLKPVVAPKTAMP 312
            .:.:.||:......|.|.:....::.........:.:.:..|:..:|.|:.:..:|...|.|
  Rat   436 FQHRQSQLLHTATHLQLAQQQQQQQQQQQQQQQQQQQQQQQQQQQQQATTLAAPQPPQVPPT--- 497

  Fly   313 IATEVPTADNNKMSLIKSKPVAIKAVPLPSQEAPIVPAVAPVVTSPEKVDVKPTAKPSIKTAPKP 377
              .:||                    |..||:......|.|::.|      .|.:.|     |:|
  Rat   498 --QQVP--------------------PSQSQQQAQTLVVQPMLQS------SPLSLP-----PEP 529

  Fly   378 TPKPLEMSVNGPAKEKKAPAKEQKQKTMDKPPVVKEIAQHTPCGPKELPKLKRSKSFVSNHPAS- 441
            ||||              |...|     .||||          .|.:.|:|..:|...:..|..
  Rat   530 TPKP--------------PIPIQ-----SKPPV----------APIKPPQLGAAKMSATQQPPPH 565

  Fly   442 -PVANNERRHSVAIMAKEVDVIEQPSAAIETITIEDDDESEEEQQKPEIKKTPKQ----NQKPEK 501
             ||.....|......|:.:. :.|.:||:.|           .:..|...: |.|    :.:|..
  Rat   566 IPVQVVGTRQPGTAQAQALG-LAQLAAAVPT-----------SRGMPGAVQ-PGQAHLASSQPSS 617

  Fly   502 QEAPKKKQIPMPILPAGITIS----TTSTAKKKAVRKNSSVTTISSSSSDSSSYSDVEVVPTKKT 562
            | ||...|...|.|..|:|::    |....|......:..|..:.::....|.:
  Rat   618 Q-APGALQECPPALATGMTLAPVQGTAHVVKGGPTASSPVVAQVPAAFYMQSVH----------- 670

  Fly   563 EKELSMLPGISIIKAESLPLSREDFERSLRCDEQV--PQTPPKSSSSSSS-------GSHASEMS 618
                  |||    ||::|.:.|:......|.|...  ...|.|:|.::.|       .|...:..
  Rat   671 ------LPG----KAQTLAVKRKAESEEEREDLSALGSVLPTKASPAAESPKVIEEKNSLVEKAE 725

  Fly   619 P-------PPK-----LADPKPSSPPAKNAKKAND-HDANP-----SPSSKTNDFKKSMMQNLNM 665
            |       ||.     || |.||:||...|..:.. .|:.|     .|...|:..:..::|
  Rat   726 PVASLNANPPNSDLVALA-PTPSAPPPTLALVSRQMGDSKPPQAIVKPQILTHIIEGFVIQ---- 785

  Fly   666 LKWRGQQPANLQNSTVRFELNEFNFLQINERCQPRQGPAAYFER----PLYDRPGRRPSACV--- 723
               .|.:|         |.:....||:..|:..|...|....|.    ||   .|..|  ||
  Rat   786 ---EGAEP---------FPVGCSQFLKETEKPLPAGLPTGLNESQSGGPL---GGDSP--CVDLD 833

  Fly   724 -HPLLYLCQRCNFHGPAADFL-APHFCSVGCVRR-----SQKRRLPQSTQK---ESKISRTQLEQ 778
             ...|..|:.|..:.||..|. :..|||:.|.:|     |.:.||.:...|   |:..:|.:...
  Rat   834 KKANLLKCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSHQFRLKRKKMKEFQEASYARVRRRG 898

  Fly   779 TAGTAPDLPQKRQTNYKPHKSLSAIQEQLQQRQKDKPR 816
            ...::.|:.:.:            ||.:..:.|:|..|
  Rat   899 PRRSSSDIARAK------------IQGKRHRGQEDSSR 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723
		MBT	929..1028	CDD:214723
		MBT	1038..1130	CDD:214723
		SAM_PNT	1279..1366	CDD:280377
Phc1	XP_006237362.1	zf-FCS	833..868	CDD:283998	10/34 (29%)
		PHC2_SAM_assoc	869..975	CDD:293222	12/68 (18%)
		SAM_Ph1,2,3	976..1044	CDD:188976
		SAM	978..1045	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343702
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840