DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)mbt and L3mbtl2

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_008763933.1	Gene:	L3mbtl2 / 300320	RGDID:	1308569	Length:	728	Species:	Rattus norvegicus

Alignment Length:	744	Identity:	154/744 - (20%)
Similarity:	262/744 - (35%)	Gaps:	241/744 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   621 PKLADPKPSSPPAKNAKKANDHDA------------NPSPSSKTNDFKKSMMQNLNMLKWRGQQP 673
            |:..:..|||.|   .::..|.|.            |.|..|:::.:.:...:..|..:..|:.|
  Rat     4 PRGTEETPSSEP---MEEEEDDDLELFGGYDSFRSYNSSAGSESSSYLEESSEAENEDREAGELP 65

  Fly   674 ANLQNSTVRFELNEFNFLQINERCQPRQGPAAYFERPLYDRPGRRPSACVHPLLYLCQRCNFHGP 738
                  |....|    |...|.|.              .|..|..|:        :|:.|...|.
  Rat    66 ------TSPLHL----FSSANNRA--------------LDGSGSEPA--------VCEMCGIVGT 98

  Fly   739 AADFLA--PHFCSVGCVRRSQKRRLPQSTQKESKISRTQLEQTAGTAPDLPQKRQTNYKPHKS-- 799
            ...|.:  ..||||.|     .|....:::|.|.::|.|     |..|  .:|.:..:|...|
  Rat    99 REAFFSKTKRFCSVSC-----SRSYSSNSKKASILARLQ-----GKPP--TKKAKVLHKAAWSAK 151

  Fly   800 LSAIQEQLQQRQ--------KDKPRKPFRWSEYLKSKGKDVAAPIHLFLNPFPISPNCFEI--GM 854
            :.|........|        :|.....|.|.::||..... |||:..|.: .|:.....::  ||
  Rat   152 IGAFLHAQGTGQLADGTPTGQDALVLGFDWGKFLKDHSYK-AAPVGCFKH-VPLYDQWEDVMKGM 214

  Fly   855 KLEAIDPE---NCSLFCVCSIVEVRGYRLKLSFDGY--SSMYDFWVNADSQDIFPPGWCDETARV 914
            |:|.::.:   ...::.:.::::..|||:.|.::|:  .:.:|||.|..:.|:.|.|||...:::
  Rat   215 KVEVLNSDAVLPSRVYWIATVIQAAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKI 279

  Fly   915 LQAPKDYNSERFSWSRYLVK--TGGKAAPRALFGHLNMQQQMDVRNGFAVGMHLEAEDLNDTGKI 977
            |..|:..:::...|..||:|  .|.:..|...  |:.|.:.|  :..|..||.||..|.....:.
  Rat   280 LVPPRTIHAKFTDWKSYLMKRLVGSRTLPADF--HIKMVESM--KYPFRQGMRLEVVDKTQVSRT 340

  Fly   978 CVATVTDILDERIRVHFDGWDDCYDLWVHITSPYIHPCGW------------------------- 1017
            .:|.|..::..|:|:.::..|...|.|.|:.||.|||.||
  Rat   341 RMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSERRCDMSHHPTFRK 405

  Fly  1018 -----------------------HEGRQ------------------------------------- 1022
                                   .||.:
  Rat   406 IYCDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDPLNLGNICVATICKVLLDGYLMICVDGGPSTD 470

  Fly  1023 -------------------------QLIVPPDYQKSAFIWDDYISEVGGMAASKELFTPRQPME- 1061
                                     :|..|..|:...|.|:.|:.:....||...||....|..
  Rat   471 GSDWFCYHASSHAIFPATFCQKNDIELTPPKGYETQPFDWESYLEKTKSKAAPARLFNMDCPNHG 535

  Fly  1062 YQERMKLEVVDQRNPCLIRPATVVTRKGYRVQLHLDCWPTEYYFWLEDDSPDLHPIGWCEATSHE 1126
            ::..||||.||...|.||..|||.......:.:|.|.|..||..|::.:|||::|:||||.|.::
  Rat   536 FKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQ 600

  Fly  1127 LETPPGYLQPKSVMPCDVEGCRGFGNAKRFNLNVHALRECCPYAPENWRQWRSKTVKPPRVAPEN 1191
            |: ||...:|.:                                |:..:.           |.:.
  Rat   601 LQ-PPVSAEPNT--------------------------------PQKGKD-----------ATKK 621

  Fly  1192 IRRGWAKKTKRACSEAKQAIKEDSQQEIV 1220
            .::.:.||.||..|...:.:::.|::.::
  Rat   622 KKKQFGKKRKRIPSAKTRPLRQSSKKPLL 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	26/102 (25%)
		MBT	929..1028	CDD:214723	32/210 (15%)
		MBT	1038..1130	CDD:214723	34/92 (37%)
		SAM_PNT	1279..1366	CDD:280377
L3mbtl2	XP_008763933.1	MBT	183..283	CDD:214723	26/101 (26%)
		MBT	294..390	CDD:214723	29/99 (29%)
		MBT	433..504	CDD:280910	2/70 (3%)
		MBT	511..604	CDD:214723	34/93 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910