DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)mbt and Scmh1

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001153102.1	Gene:	Scmh1 / 29871	MGIID:	1352762	Length:	706	Species:	Mus musculus

Alignment Length:	684	Identity:	155/684 - (22%)
Similarity:	239/684 - (34%)	Gaps:	197/684 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   815 PRKPFRWSEYLKSKGKDVAAPIHLFLNPFPISPNCFEIGMKLEAIDPENCSLFCVCSIVEVRGYR 879
            |...|.|.:||| :...|.||:|.|...:....|.|:|.|||||.||.|.:..|:.::|.:.|.|
Mouse    24 PLGHFTWDKYLK-ETCSVPAPVHCFKQSYTPPSNEFKISMKLEAQDPRNTTSTCIATVVGLTGAR 87

  Fly   880 LKLSFDGYSSMYDFWVNADSQDIFPPGWCDETARVLQAPKDYNSERFSWSRYLVKT--GGKAAPR 942
            |:|..||..:..|||...||.:|.|.|.|::...:||.|..:.....||..:|:||  |.:.||.
Mouse    88 LRLRLDGSDNKNDFWRLVDSSEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPI 152

  Fly   943 ALFGHLNMQQQMDVRNGFAVGMHLEAEDLNDTGKICVATVTDILDERIRVHFDGWDDCYDLWVHI 1007
            .:|   :.:......|.|.:||.|||.|..:...||.||:.::....:.|.||||...:|.|...
Mouse   153 KIF---HKEPPSPSHNFFKMGMKLEAVDRKNPHFICPATIGEVRGAEVLVTFDGWRGAFDYWCRF 214

  Fly  1008 TSPYIHPCGW--------HEGRQQLIVP-------------PDYQKSAFIWDDYISEVGGMAASK 1051
            .|..|.|.||        .....::::|             |....:..:.:....:.|.....|
Mouse   215 DSRDIFPVGWCSLTGDNLQPPGTKVVIPKNPSPSSDVSTEKPSIHSTKTVLEHQPGQRGRKPGKK 279

  Fly  1052 ELFTPR--------------QPMEYQERMKLEVVDQRNP--CLIRPATVVTRKGYRVQLHLDCWP 1100
            ...||:              :|:::.::...:...:|.|  .|..|.|..|
Mouse   280 RGRTPKILIPHPTSTPSKSAEPLKFPKKRGPKPGSKRKPRTLLSPPPTSPT-------------- 330

  Fly  1101 TEYYFWLEDDSPDLHPIGWCEATSHELETPPGYLQPKSVMPC---DVEGCRG------------- 1149
                  .....||...:....||     .|...:|..:|  |   :..|..|
Mouse   331 ------TSTPEPDTSTVPQDAAT-----VPSSAMQAPTV--CIYLNKSGSTGPHLDKKKIQQLPD 382

  Fly  1150 -FGNAKRFNLNVHALREC--CPYAPENWRQWRSKTVKPPRVAPENIRRGWAKKTKRACSEAKQAI 1211
             ||.|:...:...|::.|  |.|        ..|||.      ..:::|..       .|...|:
Mouse   383 HFGPARASVVLQQAVQACIDCAY--------HQKTVF------SFLKQGHG-------GEVISAV 426

  Fly  1212 KEDSQQEIVYPKVAEVVQAKR---------------KTSPCEEKVVKKQKQMQKEEDAEQVPDER 1261
            .:..|..:..|.|..:....|               ...|..:..:..............:|.|.
Mouse   427 FDREQHTLNLPAVNSITYVLRFLEKLCHNLRSDNLFGNQPFTQTHLSLTATEYNHNHDRYLPGET 491

  Fly  1262 SL---AIARSF------------------------VKDYGPQFLPNYRL---------------- 1283
            .:   ::|||.                        ...|.| .||:..|
Mouse   492 FVLGNSLARSLETHSDLMDSALKPANLVSTSQNLRTPGYRP-LLPSCGLPLSTVSAVRRLCSKGV 555

  Fly  1284 -------------WQLNSA-------FKLDDVR---TNPLHWTSWDVCEYIERA---LDSTDIAK 1322
                         |:||.:       ...|..|   .:|..||..||.:::..|   |.|.  |.
Mouse   556 LKGKKERRDVESFWKLNHSPGSDRHLESRDPPRLSGRDPSSWTVEDVMQFVREADPQLGSH--AD 618

  Fly  1323 VIFEQDIDGRALLMLGRKELDTYLKLKVGPAVKL 1356
            :..:.:|||:|||:|....:..|:.||:|||:||
Mouse   619 LFRKHEIDGKALLLLRSDMMMKYMGLKLGPALKL 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	38/95 (40%)
		MBT	929..1028	CDD:214723	32/121 (26%)
		MBT	1038..1130	CDD:214723	15/107 (14%)
		SAM_PNT	1279..1366	CDD:280377	31/120 (26%)
Scmh1	NP_001153102.1	MBT 1	28..126		40/98 (41%)
		MBT	31..126	CDD:214723	38/95 (40%)
		MBT 2	134..235		33/103 (32%)
		MBT	137..235	CDD:214723	31/100 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	233..350		17/141 (12%)
		DUF3588	357..465	CDD:288954	21/130 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	576..595		2/18 (11%)
		SAM_Scm	591..661	CDD:188977	24/64 (38%)
		SAM	594..661	CDD:197735	24/61 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839859
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840