DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)mbt and L3mbtl3

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001346183.1	Gene:	L3mbtl3 / 237339	MGIID:	2143628	Length:	883	Species:	Mus musculus

Alignment Length:	878	Identity:	255/878 - (29%)
Similarity:	381/878 - (43%)	Gaps:	194/878 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   664 NMLKWRGQQPANLQNSTVRFELNEFNFLQI------NERCQPRQGPAAYFERPLYDRPGRRPSA- 721
            :::.|: .....|..|.::|.:|||..|::      .|..:.......:......|.|...||:
Mouse    17 SVMDWK-DGVGTLPGSDLKFRVNEFGALEVITDESEMESVKKATATTTWMVPTAQDAPTSPPSSR 80

  Fly   722 CVHPLLY-------------------------------LCQRCNFHGPAADFLA-PHFCSVGCVR 754
            .|.|..|                               .|:.|..:|...:.|: ..:||..|.|
Mouse    81 PVFPPAYWTSPPGCPTVFSEKTGVPFRLKEQSKADGLQFCENCCQYGNGDECLSGGKYCSQNCAR 145

  Fly   755 RSQKRRLPQSTQKESKISRTQLEQTAGTAPDLPQKRQTNYKPHKSLSA----------------- 802
            .::        .|:.|..|...|......|...:|:    ||..||.|
Mouse   146 HAK--------DKDQKDERDGGEDNDEEDPKCSRKK----KPKLSLKADSKDDGEERDDEMENKQ 198

  Fly   803 -------IQEQLQQRQKD----------KPRKPFRWSEYLKSKGKDVAAPIHLFL--NPFPISPN 848
                   .|...::|:.|          |.:|.:.|:.||:.: |.||.|..||.  ..||.:.|
Mouse   199 DGRILRGSQRARRKRRGDSAVLKQGLPPKGKKTWCWASYLEEE-KAVAVPTKLFKEHQSFPYNKN 262

  Fly   849 CFEIGMKLEAIDPENCSLFCVCSIVEVRGYRLKLSFDGYSSMYDFWVNADSQDIFPPGWCDETAR 913
            .|::|||||.:||::.:::||.::.||.|||:||.|||||..||||||||:.||.|.|||::|..
Mouse   263 GFKVGMKLEGVDPDHQAMYCVLTVAEVCGYRIKLHFDGYSDCYDFWVNADALDIHPVGWCEKTGH 327

  Fly   914 VLQAPKDYNSERFSWSRYLVKTGGKAAPRALFGHLNMQQQMDVRNGFAVGMHLEAEDLNDTGKIC 978
            .|:.||.|..|.|:|..||.....:|||::||.:.|:..   :.:||.|||.|||.|......||
Mouse   328 KLRPPKGYKEEEFNWQSYLKTCKAQAAPKSLFENQNITV---IPSGFRVGMKLEAADKKSPSVIC 389

  Fly   979 VATVTDILDERIRVHFDGWDDCYDLWVHITSPYIHPCGW-HEGRQQLIVPPDYQK-SAFIWDDYI 1041
            ||||||::|.|..||||.||:.||.|....||:|||.|| .|.|:.||.||.|.. ..|.||.|:
Mouse   390 VATVTDMVDNRFLVHFDNWDESYDYWCESNSPHIHPVGWCKEHRRTLITPPGYSHVKHFSWDKYL 454

  Fly  1042 SEVGGMAASKELFTPRQPMEYQERMKLEVVDQRNPCLIRPATVVTRKGYRVQLHLDCWPTEYYFW 1106
            .|...:.|....|..:.|..:|::||||.||:|||..||.|||.....:|:::|.|.|.:.|.:|
Mouse   455 EETNSLPAPARAFKVKPPHGFQKKMKLEAVDKRNPLFIRVATVADTDDHRIKVHFDGWSSCYDYW 519

  Fly  1107 LEDDSPDLHPIGWCEATSHELETP--PGYL-QPKSVMPCDVEGCRGFGNAKRFNLNVHALRECCP 1168
            ::.||||:||:|||..|.|.|:.|  |..| :|.....|...||||.|:.|:...........||
Mouse   520 IDADSPDIHPVGWCSKTGHPLQAPLSPAELMEPSETGGCPTLGCRGVGHFKKSRYLGTQSGANCP 584

  Fly  1169 YAPENWRQWR------SKTVKPPRV----------------APE-------NIRRGWAKKTK--- 1201
            |:..|..:.|      |....||..                :||       |.:....||.:
Mouse   585 YSEINLSKERIFPDRLSGDTSPPTTPSFPRSKRMDTRESSSSPETREKHANNFKEDSEKKKENEV 649

  Fly  1202 RACSEAKQAIKEDS--------------------------------------------------- 1215
            :..:|||...:|.:
Mouse   650 KTSAEAKVVREEPTPSVQQSQPPQQVQQVQHAQPPQQAQKAPQAQQAQQAQQAQQAPQAPQTPQP 714

  Fly  1216 ------QQEIVYPKVAEVVQAKRKTSPCEEKVVKKQKQMQKEEDAEQVPDERSLAIARSFV-KDY 1273
                  ||....|:..:..|.::...|.:...|::.:|:|:.:..:|....:..|..||.| ..:
Mouse   715 QQAPQVQQAQQAPQAQQAQQPQQAQQPQQAPPVQQPQQVQQAQPTQQQAQTQQQAQRRSAVFLSF 779

  Fly  1274 GPQFLPNYRL-WQLNSAFKLDDVRTNPL----HWTSWDVCEYIERALDSTDIAKVIFEQDIDGRA 1333
            .|. :|...| |:..|.. |..|...|.    .|::.:|.|:|:......:..||..::.|||.|
Mouse   780 KPP-IPCLPLRWEQQSKL-LPTVAGIPASRVSKWSTDEVSEFIQSLPGCEEHGKVFKDEQIDGEA 842

  Fly  1334 LLMLGRKELDTYLKLKVGPAVKLYSLILNLRIA 1366
            .|::.:.::...:.:|:|||:|:::.||..:.|
Mouse   843 FLLMTQTDIVKIMSIKLGPALKIFNSILMFKAA 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	49/97 (51%)
		MBT	929..1028	CDD:214723	47/99 (47%)
		MBT	1038..1130	CDD:214723	39/91 (43%)
		SAM_PNT	1279..1366	CDD:280377	25/91 (27%)
L3mbtl3	NP_001346183.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..223		14/88 (16%)
		MBT 1	232..332		50/100 (50%)
		MBT	236..332	CDD:214723	49/96 (51%)
		MBT 2	340..439		49/101 (49%)
		MBT	343..439	CDD:214723	47/98 (48%)
		MBT 3	448..543		41/94 (44%)
		MBT	451..543	CDD:214723	39/91 (43%)
		zf-C2HC	558..586	CDD:366692	9/27 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	595..768		21/172 (12%)
		SAM_Scm-like-3MBT3,4	808..873	CDD:188981	18/64 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839857
Domainoid	1	1.000	96	1.000	Domainoid score	I7303
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H18226
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002225
OrthoInspector	1	1.000	-	-		otm43427
orthoMCL	1	0.900	-	-		OOG6_104389
Panther	1	1.100	-	-	O	PTHR12247
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5341
SonicParanoid	1	1.000	-	-		X1471
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.870