DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)mbt and L3mbtl2

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001276640.1	Gene:	L3mbtl2 / 214669	MGIID:	2443584	Length:	739	Species:	Mus musculus

Alignment Length:	773	Identity:	160/773 - (20%)
Similarity:	276/773 - (35%)	Gaps:	245/773 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   621 PKLADPKPSSPPAKNAKKANDHDA----------NPSPSSKTNDFKKSMMQNLNMLKWRGQQPAN 675
            |:..:..|||.|.:. ::.:|.|.          |.|..|:::.:.:...:..|..:..|:.|
Mouse     4 PRGTEEAPSSEPMEE-EEEDDLDLFGGYDSFRSYNSSAGSESSSYLEESSEAENEDREAGELP-- 65

  Fly   676 LQNSTVRFELNEFNFLQINERCQPRQGPAAYFERPLYDRPGRRPSACVHPLLYLCQRCNFHGPAA 740
                |....|    |...|.|.              .|..|..|:        :|:.|...|...
Mouse    66 ----TSPLHL----FSSANNRS--------------LDGSGSEPA--------VCEMCGIVGTRE 100

  Fly   741 DFLA--PHFCSVGCVRRSQKRRLPQSTQKESKISRTQLEQTAGTAPDLPQKRQTNYKPHKS--LS 801
            .|.:  ..||||.|     .|....:::|.|.::|.|     |..|  .:|.:..:|...|  :.
Mouse   101 AFFSKTKRFCSVSC-----SRSYSSNSKKASILARLQ-----GKPP--TKKAKVLHKAAWSAKIG 153

  Fly   802 AIQEQLQQRQ--------KDKPRKPFRWSEYLKSKGKDVAAPIHLFLNPFPISPNCFEI--GMKL 856
            |........|        :|.....|.|.::||..... |||:..|.: .|:.....::  |||:
Mouse   154 AFLHAQGTGQLADGTPTGQDALVLGFDWGKFLKDHSYK-AAPVSCFKH-VPLYDQWEDVMKGMKV 216

  Fly   857 EAIDPE---NCSLFCVCSIVEVRGYRLKLSFDGY--SSMYDFWVNADSQDIFPPGWCDETARVLQ 916
            |.::.:   ...::.:.::::..|||:.|.::|:  .:.:|||.|..:.|:.|.|||...:::|.
Mouse   217 EVLNSDAVLPSRVYWIATVIQAAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILV 281

  Fly   917 APKDYNSERFSWSRYLVK--TGGKAAPRALFGHLNMQQQMDVRNGFAVGMHLEAEDLNDTGKICV 979
            .|:..:::...|..||:|  .|.:..|...  |:.|.:.|  :..|..||.||..|.....:..:
Mouse   282 PPRTIHAKFTDWKSYLMKRLVGSRTLPADF--HIKMVESM--KYPFRQGMRLEVVDKTQVSRTRM 342

  Fly   980 ATVTDILDERIRVHFDGWDDCYDLWVHITSPYIHPCGW--------------------------- 1017
            |.|..::..|:|:.::..|...|.|.|:.||.|||.||
Mouse   343 AVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSDRRCDMSHHPTFRKIY 407

  Fly  1018 ---------------------HEGRQ--------------------------------------- 1022
                                 .||.:
Mouse   408 CDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDPLNLGSICVATICKVLLDGYLMICVDGGPSTDGS 472

  Fly  1023 -----------------------QLIVPPDYQKSAFIWDDYISEVGGMAASKELFTPRQPME-YQ 1063
                                   :|..|..|:...|.|:.|:.:....||...||....|.. ::
Mouse   473 DWFCYHASSHAIFPATFCQKNDIELTPPKGYETQPFAWETYLEKTKSKAAPARLFNMDCPNHGFK 537

  Fly  1064 ERMKLEVVDQRNPCLIRPATVVTRKGYRVQLHLDCWPTEYYFWLEDDSPDLHPIGWCEATSHELE 1128
            ..||||.||...|.||..|||.......:.:|.|.|..||..|::.:|||::|:||||.|.::|:
Mouse   538 VGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQ 602

  Fly  1129 TPPGYLQPKSVMPCDVEGCRGFGNAKRFNLNVHALRECCPYAPENWRQWRSKTVKPPRVAPENIR 1193
             ||...:|.:                                |:..:....|.           :
Mouse   603 -PPVSAEPNT--------------------------------PQKGKDTTKKK-----------K 623

  Fly  1194 RGWAKKTKRACSEAKQAIKEDSQQEIVYPKVAEVVQAKRKTSPCEEKV----VKKQKQ 1247
            :.:.||.||..|...:.:::.|::    |.:.:.::|...:.|..:.:    ||::.|
Mouse   624 KQFGKKRKRIPSAKTRPLRQGSKK----PLLEDNLEALGVSEPVPDDIIAVCVKEEHQ 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	26/102 (25%)
		MBT	929..1028	CDD:214723	32/210 (15%)
		MBT	1038..1130	CDD:214723	34/92 (37%)
		SAM_PNT	1279..1366	CDD:280377
L3mbtl2	NP_001276640.1	MBT	183..283	CDD:214723	26/101 (26%)
		MBT	294..390	CDD:214723	29/99 (29%)
		MBT	433..504	CDD:280910	2/70 (3%)
		MBT	511..604	CDD:214723	34/93 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910