Protein Alignment l(3)mbt and PHC2

DIOPT Version :10

• Sequence 1: NP_733209.1
• Gene: l(3)mbt / 43288
• FlyBaseID: FBgn0002441
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: NP_001372041.1
• Gene: PHC2 / 1912
• HGNCID: 3183
• Length: 881
• Species: Homo sapiens
• Alignment Length: 1008
• Identity: 192/1008 - (19%)
• Similarity: 331/1008 - (32%)
• Gaps: 322/1008 - (31%)

  Fly     2 LPLSMASAEAKQLQRNISLSMSPANGGVISPSTANCNGVASASGGNPNPN----SLLTLAPRKEE 62
            ||:...|:.|        .:.|..:|   :.|::.||.  |:|||:..|.    |:.:..|.::.
Human     5 LPVPHTSSSA--------CATSSTSG---ASSSSGCNN--SSSGGSGRPTGPQISVYSGIPDRQT 56

  Fly    63 LRFLP-------------LAPMGGNKTCNITISNVQPMKSKLKSVN------IVPNSIKSAGAGA 108
            ::.:.             |..|...:..::.:......:..|.|..      :...|:.|...|:
Human    57 VQVIQQALHRQPSTAAQYLQQMYAAQQQHLMLQTAALQQQHLSSAQLQSLAAVQQASLVSNRQGS 121

  Fly   109 TVG---SADAPL----FQLVPSPS-----NPSQPLVAILAPN--RKTTLLGGGASNGQPVVIRSG 159
            |.|   ||.||.    ..|..||:     |.:|.:.:..|..  ::..|||..:|   |.:..|.
Human   122 TSGSNVSAQAPAQSSSINLAASPAAAQLLNRAQSVNSAAASGIAQQAVLLGNTSS---PALTASQ 183

  Fly   160 TPLHKNSLTVETSNKPIQPGGSAAAAAVGGGTGGAPLTLVGKTVVPPKIQAATPVQIPSTGPGAQ 224
            ..::..:       :..|||.....|...|||  .||:  .:.:..|....|| || |..|.|
Human   184 AQMYLRA-------QMAQPGNLVQVARSLGGT--VPLS--PQLIFTPTATVAT-VQ-PELGTG-- 233

  Fly   225 VSLLANPLKPRAPLILSKVAVDKLRLKFSQVKSNPNALVLGKANH---VKKLLTSPNPSGEDKTR 286
                 :|.:|..|     ..|..|.|:..|   .|.|...|....   :..|...|.|.|.....
Human   234 -----SPARPPTP-----AQVQNLTLRTQQ---TPAAAASGPTPTQPVLPSLALKPTPGGSQPLP 285

  Fly   287 S-TQKNNKQNTSASQLKPVVAPKTAMPIA-----TEVPTADNNKMSLIKSKPVAIKAVPLPSQEA 345
            : .|..|....|.:..||.:|.....|..     :.||.:...:..|.::.| |:.|.||
Human   286 TPAQSRNTAQASPAGAKPGIADSVMEPHKKGDGNSSVPGSMEGRAGLSRTVP-AVAAHPL----- 344

  Fly   346 PIVPAVAPVVTSPEKVDVKPTAK---PSIKTAPKPTPKPLEMSVNGPAKEKKAP---AKEQKQKT 404
             |.||.|.:  .|.::..:|::|   |......:|.|:..:     |..::..|   |:...|..
Human   345 -IAPAYAQL--QPHQLLPQPSSKHLQPQFVIQQQPQPQQQQ-----PPPQQSRPVLQAEPHPQLA 401

  Fly   405 MDKPPVVKE---------IAQHTPCGPKELPKLKRSKSFVSN--HPASP-----------VANNE 447
            ...|.|..:         :...||..|.:.|.....|...|.  ||.:|           |.:..
Human   402 SVSPSVALQPSSEAHAMPLGPVTPALPLQCPTANLHKPGGSQQCHPPTPDTGPQNGHPEGVPHTP 466

  Fly   448 RR---HSVAIMAKEVDVIEQPSAAIETITIEDD--DESEEEQQKPEIKKTPKQNQKPEKQEAPKK 507
            :|   |:.|::.:     .||::.:....:.||  :.:..|:..||.:..|..:|
Human   467 QRRFQHTSAVILQ-----LQPASPVPQQCVPDDWKEVAPGEKSVPETRSGPSPHQ---------- 516

  Fly   508 KQIPMPILPAGITISTTSTAKKKAVRKNSSVTTISSSSSDSSSYSDVEVVPTKKTEKELSMLPGI 572
             |..:..:|.|:.:.|:...:.....:...  .|..:.:|.||                   ||:
Human   517 -QAIVTAMPGGLPVPTSPNIQPSPAHETGQ--GIVHALTDLSS-------------------PGM 559

  Fly   573 SIIKAESLPLSREDFERSLRCDEQVPQTPPKSSSSSSSGSHASEMSPPPKLADPKPSSPPAKNAK 637
            :.....|                        :||.:.:.....|..||..:..|:..:...:..
Human   560 TSGNGNS------------------------ASSIAGTAPQNGENKPPQAIVKPQILTHVIEGF- 599

  Fly   638 KANDHDANPSPSSKTNDFKKSMMQNLNMLKWRGQQPANL--QNSTVRFELNEFNFLQINERCQPR 700
             .....|.|.|..:::    .::.||.....:|..|..|  |:.|...:
Human   600 -VIQEGAEPFPVGRSS----LLVGNLKKKYAQGFLPEKLPQQDHTTTTD---------------- 643

  Fly   701 QGPAAYFERPLYDRPGRRPSACVHPLLYLCQRCNFHGPAADFL-----APHFCSVGCVR------ 754
                :..|.| |.:..:...|   ||...|:.|.    ..||.     :..|||:.|.:
Human   644 ----SEMEEP-YLQESKEEGA---PLKLKCELCG----RVDFAYKFKRSKRFCSMACAKRYNVGC 696

  Fly   755 ----------RSQKRRLPQSTQKESKISRTQL--------EQTAGTAP-------DLPQKRQ--- 791
                      ||:.::...:|....:.|:..|        :|..||.|       .|...::
Human   697 TKRVGLFHSDRSKLQKAGAATHNRRRASKASLPPLTKDTKKQPTGTVPLSVTAALQLTHSQEDSS 761

  Fly   792 -----TNY-KPHKSLSAIQEQLQQRQKDK--------------------PRKPFRWS-----EYL 825
                 ::| :|...:||.....::||..:                    |.:|.:|:     |::
Human   762 RCSDNSSYEEPLSPISASSSTSRRRQGQRDLELPDMHMRDLVGMGHHFLPSEPTKWNVEDVYEFI 826

  Fly   826 KSKGKDVAAPIHLFLNPFPISPNCFEIGMKLEA 858
            :|                  .|.|.||..:..|
Human   827 RS------------------LPGCQEIAEEFRA 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	PRK10819	<332..>427	CDD:236768	24/109 (22%)
		MBT_L3MBTL1-like_rpt1	846..945	CDD:439091	5/13 (38%)
		MBT_L3MBTL1-like_rpt2	957..1045	CDD:439092
		MBT_L3MBTL1-like_rpt3	1058..1130	CDD:439093
		SAM_PNT	1278..1367	CDD:460486
PHC2	NP_001372041.1	PHA03247	<116..571	CDD:223021	117/560 (21%)
		PHC2_SAM_assoc	693..812	CDD:465202	16/118 (14%)
		SAM_Ph1,2,3	812..880	CDD:188976	9/48 (19%)