DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)mbt and PHC1

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_011518905.1	Gene:	PHC1 / 1911	HGNCID:	3182	Length:	1021	Species:	Homo sapiens

Alignment Length:	968	Identity:	200/968 - (20%)
Similarity:	309/968 - (31%)	Gaps:	335/968 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ASAEAKQLQRNISLSMSPANGGVISPSTANCN--GVASASGGNPNPNSLLTLAPRKEELRFLPLA 69
            |||:..|:|.:...::.|....|.|.|.|:..  .||.||.|..|.:              |.|:
Human   232 ASAQGPQMQGSTQKAIPPGASPVSSLSQASSQALAVAQASSGATNQS--------------LNLS 282

  Fly    70 PMGGNKTCNITISNVQPMKSKLKSVNIVPNSIKSAGAGATVGSADAPLFQLVPSPSNPSQPLVAI 134
            ..||.                  |.|.:|.|:...|.|...|.    |.||   ||:.
Human   283 QAGGG------------------SGNSIPGSMGPGGGGQAHGG----LGQL---PSSG------- 315

  Fly   135 LAPNRKTTLLGGGASNGQPVVIRSGT----PLHKNSLTVETSNKPIQPGGSAAAAAVGGGTG--- 192
                     :|||:..      |.||    ||........:.....:...:||..|...|:|
Human   316 ---------MGGGSCP------RKGTGVVQPLPAAQTVTVSQGSQTEAESAAAKKAEADGSGQQN 365

  Fly   193 -GAPLTLVGKTVVPPK----IQAATPVQIPSTGPGAQVSLLANP----LKPRAPLILSKVAVDKL 248
             |..||   :|..|..    |.:||..||...      ||:...    |:.:..:|..::|:..
Human   366 VGMNLT---RTATPAPSQTLISSATYTQIQPH------SLIQQQQQIHLQQKQVVIQQQIAIHH- 420

  Fly   249 RLKFSQVKSNPNALVLGKANHVKKLLTSPNPSGEDKTRSTQKNNKQNTSASQLKPVVAPKTAMPI 313
            :.:|...:|.    :|..|.|::              .:.|:..:|.....|.:|.....|| |.
Human   421 QQQFQHRQSQ----LLHTATHLQ--------------LAQQQQQQQQQQQQQQQPQATTLTA-PQ 466

  Fly   314 ATEVPTADNNKMSLIKSKPVAIKAVPLPSQEAPIVPAVAPVVTSPEKVDVKPTAKPSIKTAPKPT 378
            ..:||...              :..|..||:......|.|::.|      .|.:.|. ..||||
Human   467 PPQVPPTQ--------------QVPPSQSQQQAQTLVVQPMLQS------SPLSLPP-DAAPKP- 509

  Fly   379 PKPLEMSVNGPAKEKKAPAKEQKQKTMDKPPVVKEIAQHTPCGPKELPKLKRSKSFVSNHPAS-- 441
            |.|::                      .||||          .|.:.|:|..:|...:..|..
Human   510 PIPIQ----------------------SKPPV----------APIKPPQLGAAKMSAAQQPPPHI 542

  Fly   442 PVANNERRHSVAIMAKEVDVIEQPSAAIETI-----TIEDDDESEEEQQKPEIKKTPKQNQKP-E 500
            ||.....|......|:.:. :.|.:||:.|.     |::..        :..:..:|..:|.| .
Human   543 PVQVVGTRQPGTAQAQALG-LAQLAAAVPTSRGMPGTVQSG--------QAHLASSPPSSQAPGA 598

  Fly   501 KQEAPKKKQIPMPILPAGITIS----TTSTAKKKAVRKNSSVTTISSSSSDSSSYSDVEVVPTKK 561
            .||.|       |.|..|:|::    |....|..|...:..|..:.::....|.:
Human   599 LQECP-------PTLAPGMTLAPVQGTAHVVKGGATTSSPVVAQVPAAFYMQSVH---------- 646

  Fly   562 TEKELSMLPGISIIKAESLPLSREDFERSLRCD------------EQVPQTPPKSSSSSSSGSHA 614
                   |||    |.::|.:.|:......|.|            ..|.::|......||.|..|
Human   647 -------LPG----KPQTLAVKRKADSEEERDDVSTLGSMLPAKASPVAESPKVMDEKSSLGEKA 700

  Fly   615 SEM------SPPPKLA--DPKPSSPPAKNAKKAND-HDANP-----SPSSKTNDFKKSMMQNLNM 665
            ..:      :|..:|.  .|.||.||...|..:.. .|:.|     .|...|:..:..::|
Human   701 ESVANVNANTPSSELVALTPAPSVPPPTLAMVSRQMGDSKPPQAIVKPQILTHIIEGFVIQ---- 761

  Fly   666 LKWRGQQPANLQNSTVRFELNEFNFLQINERCQPRQGPAAYFER----PL-YDRPGRRPSACVHP 725
               .|.:|         |.:.....|:.:|:......|....|.    || .|.|........:
Human   762 ---EGAEP---------FPVGCSQLLKESEKPLQTGLPTGLTENQSGGPLGVDSPSAELDKKAN- 813

  Fly   726 LLYLCQRCNFHGPAADFL-APHFCSVGCVRR-----SQKRRLPQSTQKESKISRTQLEQTAGTAP 784
             |..|:.|..:.||..|. :..|||:.|.:|     |.:.||.:...||.
Human   814 -LLKCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSHQFRLKRKKMKEF--------------- 862

  Fly   785 DLPQKRQTNYK------PHKSLS-----AIQEQLQQRQKDKPRKPFRWSEYLKSKGKD------V 832
                 ::.||.      |.:|.|     .||.:..:.|:|            .|:|.|      .
Human   863 -----QEANYARVRRRGPRRSSSDIARAKIQGKCHRGQED------------SSRGSDNSSYDEA 910

  Fly   833 AAPIHLFLNPFPIS------------PNCFEIGMKLEAIDP----ENCSLFCVCSIVE 874
            .:|    .:|.|:|            ||......:|..|:|    .|.|.:.|..:.|
Human   911 LSP----TSPGPLSVRAGHGERDLGNPNTAPPTPELHGINPVFLSSNPSRWSVEEVYE 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	16/75 (21%)
		MBT	929..1028	CDD:214723
		MBT	1038..1130	CDD:214723
		SAM_PNT	1279..1366	CDD:280377
PHC1	XP_011518905.1	zf-FCS	809..844	CDD:283998	10/36 (28%)
		PHC2_SAM_assoc	845..951	CDD:293222	26/141 (18%)
		SAM_Ph1,2,3	952..1020	CDD:188976	4/13 (31%)
		SAM	954..1021	CDD:197735	3/11 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149810
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840