DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)mbt and samd1b

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_005163590.1	Gene:	samd1b / 101884198	ZFINID:	ZDB-GENE-090313-2	Length:	626	Species:	Danio rerio

Alignment Length:	542	Identity:	107/542 - (19%)
Similarity:	179/542 - (33%)	Gaps:	188/542 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AEAKQLQRNISLSMSPANGGVISPSTANCNGVASASGGNPNPNSLLTLAPRKEELRFLPLAPMGG 73
            |.|.:.:|    |:|.|.||...|..|:..|....|.|:...:.    ...||:
Zfish   178 ASASKERR----SVSAAGGGGSGPRDASSAGEEMLSAGHEGTDE----EEEKEQ----------- 223

  Fly    74 NKTCNITISNVQPMKSKLKSVNIVPNSIKSAGAGATVGSADAPLFQLVPSPSNPSQPLVAILAPN 138
             |||:...|   |.|::|.:    |:.:|....|:.|..:|                     :|.
Zfish   224 -KTCSSVSS---PQKNRLSA----PSKLKPGVKGSAVRGSD---------------------SPE 259

  Fly   139 RKTTLLGGGASNGQPVVIRSGTPLHKNSLTVETSNKPIQPGGSAAAAAVGGGTGGAPLTLVGKTV 203
            ..:|.||....:    .:||.:..|:               ||||       |.|.
Zfish   260 ENSTDLGDRLMD----AVRSMSERHR---------------GSAA-------TRGH--------- 289

  Fly   204 VPPKIQAATPVQIPSTG-PGAQVSLLANPLKPRAPLILSKVAVDKLRLKFSQV-----------K 256
            .||.::..........| ||.:::      :.|..::|.: .:::.||:.:::           .
Zfish   290 APPGLKEILDYLCTQKGMPGEKLT------RNRVKVVLER-EIERGRLRRTRLGHITLPARGMGA 347

  Fly   257 SNPNALVLGKANHVKKLLTSPNPSGEDKTRSTQKNNKQNTSASQLKPVVAPKTAMPIATEVPTAD 321
            :.|:|.:|..|...:.|........||......:.|                     .||.|||:
Zfish   348 AKPSARLLKSALQDRHLAKKEELKDEDGMEVESEGN---------------------GTEEPTAE 391

  Fly   322 NNKMSLIKSKPVAIKA---VPLPSQEAPIVPAV-APVVTSPEKVDVKPTAKPSIKTAPKPTPKPL 382
            :...::....||::|.   .|.|..||....|. :|::|.               .....|...|
Zfish   392 DLPETVPDEDPVSVKTGTEPPSPEMEAESDHATRSPMMTC---------------EGESQTSSSL 441

  Fly   383 EMSVNGPAKEKKAPAKEQKQKTM---------DKP--------PVVKE---IAQHTPCGPKELP- 426
            ::| |..:..::|...|.:::||         :||        |.|::   :...|...|..:|
Zfish   442 QLS-NHCSILQQADVGESQEQTMCAEAEDSGTEKPADPSDQRHPSVEDQMLVMSETVKPPSSIPI 505

  Fly   427 ----KLKRSKSFVSNHP-ASPVANNER--RHSVAIMAKEVDVIEQ-----------------PSA 467
                ||:...|.....| |||.|..||  ...:..:..|..|:..                 |..
Zfish   506 RNCCKLEVGVSSCLLTPSASPGAAEERGMNEGIGFVKSESSVVSPVDWTVADVASYFTAAGFPEQ 570

  Fly   468 AIETITIEDDDESEEEQQKPEI 489
            ||...|.|.|.:|....|:.::
Zfish   571 AIAFRTQEIDGKSLLLMQRNDV 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723
		MBT	929..1028	CDD:214723
		MBT	1038..1130	CDD:214723
		SAM_PNT	1279..1366	CDD:280377
samd1b	XP_005163590.1	SAM_Atherin-like	550..618	CDD:188982	8/43 (19%)
samd1b	XP_005163590.1	SAM	550..617	CDD:197735	8/43 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910