DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)mbt and l3mbtl3

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_004911641.2	Gene:	l3mbtl3 / 100496330	XenbaseID:	XB-GENE-1219135	Length:	778	Species:	Xenopus tropicalis

Alignment Length:	796	Identity:	249/796 - (31%)
Similarity:	361/796 - (45%)	Gaps:	160/796 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   663 LNMLKWRGQQPANLQNSTVRFELNEFNFLQINERCQ-------PRQGPA----------AYFER- 709
            :|.|.|| ...|.|..|.:||.|:||..|:|.....       |:.|.|          :.|.:
Frog    38 MNALDWR-DGIATLPGSHIRFRLSEFGTLEIITDSDSVVTATLPQSGQAFGTDTHTSSVSIFSQV 101

  Fly   710 -------------------PLYDRPGRRPSACVHPLLYLCQRCNFHGPAADFLAPHFCSVGCVRR 755
                               |.......:|:|.|.|.:                     :.|....
Frog   102 IKIEDKDPEMEKKTTEESLPTVQPAEEQPTAPVPPTV---------------------ASGSSTY 145

  Fly   756 SQKRRLPQSTQKESKISRTQLEQTAGTAPDLPQKRQTNYKPHKSLSAIQEQLQQRQKDK------ 814
            .:..| ||..:::.|     |...:|...||....:.|:...|    |:..|:.|:..|
Frog   146 IENER-PQRLRRKRK-----LLMDSGDEEDLLDDEEMNHWHDK----IKANLKSRKTSKQTKTAP 200

  Fly   815 -PRKP-FRWSEYLKSKGKDVAAPIHLFL--NPFPISPNCFEIGMKLEAIDPENCSLFCVCSIVEV 875
             |:|. :.|..||:.: |..|.|:..|.  ..||.|.|.|..|||||.||||:.||:||.::.||
Frog   201 PPKKKLWNWVSYLEEE-KMPAVPLKCFKEHQSFPQSRNNFRGGMKLEGIDPEHPSLYCVLTVAEV 264

  Fly   876 RGYRLKLSFDGYSSMYDFWVNADSQDIFPPGWCDETARVLQAPKDYNSERFSWSRYLVKTGGKAA 940
            :|||::|.||||...|||||||||.||.|.|||:.|...|..||.|....|||:.||.....:.|
Frog   265 QGYRMRLHFDGYPDCYDFWVNADSVDIHPVGWCERTGHKLLPPKGYKDGEFSWAAYLKHCKAQGA 329

  Fly   941 PRALFGHLNMQQQMDVRNGFAVGMHLEAEDLNDTGKICVATVTDILDERIRVHFDGWDDCYDLWV 1005
            |:.||...|...   ..:||...|.|||.|..:...:||||::||::.|:.:|||.||..||.|.
Frog   330 PKTLFKSYNTPV---TPSGFRAAMKLEAVDRKNPSLLCVATISDIVENRLLIHFDSWDHSYDYWC 391

  Fly  1006 HITSPYIHPCGW-HEGRQQLIVPPDYQ-KSAFIWDDYISEVGGMAASKELFTPRQPMEYQERMKL 1068
            ..:||||.|.|: .|....|..||:|: ...|.|:.|:.:.|..||....|.||.|..||.:|||
Frog   392 DASSPYIRPVGYCQESAIALTPPPEYKDPKCFTWEAYLEKTGAQAAPARAFKPRPPHGYQPQMKL 456

  Fly  1069 EVVDQRNPCLIRPATVVTRKGYRVQLHLDCWPTEYYFWLEDDSPDLHPIGWCEATSHELETPPGY 1133
            |.||||||.|||..:.|.:...|::||.|.|.:.|.||::.||||:||:|||..|.|.|:.|||.
Frog   457 EAVDQRNPMLIRVCSTVQKDDNRIKLHFDGWSSLYDFWVDVDSPDIHPVGWCAKTGHALQLPPGA 521

  Fly  1134 LQPKSV--MPCDVEGCRGFGNAKRFNLNVHALRECCPYAP-----ENWRQWRSKTVKPPRVAPEN 1191
            ....:|  ..|.:.||.|.|:.:......|.....|||:.     ||..|.|....:|..|  :|
Frog   522 SDMAAVAGQGCPIAGCTGIGHVRGSRYGTHYTAVGCPYSEVNLNRENLLQDRLSGERPSPV--QN 584

  Fly  1192 IRRGWAKKTKRACSEAKQAIKEDSQQEIVYPKVAEVVQAKRKTSPCEEK---------------- 1240
                 |.:::|..:.:......|      :|      |:::...|.||:
Frog   585 -----ATRSRRPGTPSPTTDSSD------FP------QSRKSPIPVEERWGRSNPWEGTEWLEEE 632

  Fly  1241 -----VVKK------QKQMQKEE----DAEQVPDERSL---AIARSFVKDYGPQFLPNYRL---W 1284
                 .:|:      :.|:.|:|    |.| |..|::|   ....|...|      |.:|:   |
Frog   633 TETKPQIKRGSHTYIRLQIIKQETDGTDCE-VSLEQALHQSVFMTSLSSD------PGHRIHMCW 690

  Fly  1285 QLNSAFKLDDVRTNPLH----WTSWDVCEYIERALDSTDIAKVIFEQDIDGRALLMLGRKELDTY 1345
            : ...:.|.:|.:....    |::.:|.:::.:....|:.:.|..::.|||.|.|:|.:.:|...
Frog   691 E-QQCYLLPEVSSYTAQSVGKWSADEVAQFVHQLPGCTEQSSVFRDEQIDGEAFLLLTQNDLVKI 754

  Fly  1346 LKLKVGPAVKLYSLIL 1361
            |.||:|||:|:|:.||
Frog   755 LGLKLGPALKIYNSIL 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	51/97 (53%)
		MBT	929..1028	CDD:214723	37/99 (37%)
		MBT	1038..1130	CDD:214723	44/91 (48%)
		SAM_PNT	1279..1366	CDD:280377	26/90 (29%)
l3mbtl3	XP_004911641.2	MBT	211..307	CDD:214723	51/96 (53%)
		MBT	319..414	CDD:214723	37/97 (38%)
		MBT	426..518	CDD:214723	44/91 (48%)
		SAM_Scm-like-3MBT3,4	708..773	CDD:188981	21/63 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7131
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H18226
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002225
OrthoInspector	1	1.000	-	-		otm48574
Panther	1	1.100	-	-	O	PTHR12247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1471
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.010