DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)mbt and l3mbtl1

DIOPT Version :9

Sequence 1:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_031750143.1	Gene:	l3mbtl1 / 100495734	XenbaseID:	XB-GENE-949999	Length:	757	Species:	Xenopus tropicalis

Alignment Length:	875	Identity:	263/875 - (30%)
Similarity:	389/875 - (44%)	Gaps:	195/875 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   554 VEVVPTK-KTEKELSMLPGISIIKAESLPLSREDFERSLRCDEQVPQTPPKSSSSSSSGSHASEM 617
            ::::.|| |:|.|:|...|....:...|..|.:        .:.|.|.||         :.:|||
Frog     1 MDLIVTKAKSEPEISAPSGKVTSEGTGLLASSQ--------TQAVVQLPP---------AFSSEM 48

  Fly   618 SPPPKLADPKPSSPPAKNAKKANDHDANPSPSSKTNDFKKSMMQNLNMLKWRGQQ---PANLQNS 679
            ..|.::  .|..:.|.|.|..|.              |.         .:|...|   |.:.|::
Frog    49 QHPQQM--EKKGAEPVKVAVNAR--------------FP---------FRWSEPQEGIPRSPQDN 88

  Fly   680 TVRFELNEFNFLQINERCQPRQGPAAYFERPLYDRPGRRPSACVHPLLYLCQRCNFHGPAADFLA 744
            .:  |:.|.::...::..:.|.|........|.|..|     |.|.:...|:.|   |....|..
Frog    89 PI--EVQETDYQTSSQDAEGRTGSPTDSGLSLCDTCG-----CRHMVGGTCETC---GDICGFKE 143

  Fly   745 PHFC------------SVGCVRRSQKRRLPQSTQK--ESKISRTQLEQTAGTAPDLPQKRQTNYK 795
            ...|            ..|...:..|:|.|:..|.  ||:...||.|          ||...:.:
Frog   144 SVHCRSLVMETSLVFGGGGETPKPVKKRRPKEYQSPAESEAEFTQKE----------QKSTGHIE 198

  Fly   796 PHKSLSAIQEQLQQR----QKDKPRKPFRWSEYLKSKGKDVAAPIHLFLNPFPIS---PNCFEIG 853
            ...:.|.::|:..||    ..|:..:|:.||.|| .:.|.:|||::|| ..:.:.   .|.|::|
Frog   199 ESLARSCVKEEWSQRDIRVSGDELGEPWSWSTYL-DELKCIAAPLNLF-REWQLGAQHKNSFKVG 261

  Fly   854 MKLEAIDPENCSLFCVCSIVEVRGYRLKLSFDGYSSMYDFWVNADSQDIFPPGWCDETARVLQAP 918
            ||||.|||::.||:.:.::.||.|:|::|.|||||..:||||||||.||.|.|||:.|...||.|
Frog   262 MKLEGIDPQHPSLYFILTVTEVCGFRIRLHFDGYSDCHDFWVNADSPDIHPAGWCERTGHKLQPP 326

  Fly   919 KDYNSERFSWSRYLVKTGGKAAPRALFGHLNMQQQMDVRNG-----FAVGMHLEAEDLNDTGKIC 978
            |.|..|.|||:.||.:|....||:.||        :..:.|     |.|||.|||.|..:...||
Frog   327 KGYKDEDFSWTNYLRQTKAPVAPKHLF--------VTPKIGAPPSLFRVGMKLEAVDRMNPSLIC 383

  Fly   979 VATVTDILDERIRVHFDGWDDCYDLWVHITSPYIHPCGWHEGRQQLIVPP-DY-QKSAFIWDDYI 1041
            ||:|||::::|..||||.|.|.||.|...:|||:||.||.|..::::.|| || ....|.|..|:
Frog   384 VASVTDVIEDRFLVHFDNWGDTYDYWCDPSSPYVHPVGWCEQHEKILTPPQDYPDPEGFSWGKYL 448

  Fly  1042 SEVGGMAASKELFTPRQPMEYQERMKLEVVDQRNPCLIRPATVVTRKGYRVQLHLDCWPTEYYFW 1106
            ||...:|...:.|.||.|..::..|:||.||:|:|.||..|:||..:.:|:::|.|.|...|.||
Frog   449 SETKTVAVPAQAFHPRPPHGFKVDMRLEAVDRRSPSLICVASVVEVEEFRIKVHFDGWSHMYDFW 513

  Fly  1107 LEDDSPDLHPIGWCEATSHELETP----------PG-----------------Y-LQPKSVMPCD 1143
            |:.|.|||||.||.:.|.|.|:||          ||                 | ||.:.   |.
Frog   514 LDADHPDLHPAGWSQRTGHPLQTPLRCRDVSNMSPGPCVSLSCKEMSHTRNNKYGLQHRK---CP 575

  Fly  1144 VEGCRGFGNAK-RFNLNVHALRECCPYAPENWRQWRSKTVKP---PRVAPENIRRGWAKKTKRAC 1204
            ..||.|.|:.. ||  ..|.....||.|..|....||:...|   .|.:..:.|.|...|.:|
Frog   576 TPGCDGSGHVTGRF--TAHHCLSGCPLADRNQNPTRSRNPIPFPSRRKSRHHGRIGRPPKYRR-- 636

  Fly  1205 SEAKQAIKEDSQQEIVYPKV---AEVVQAKRKTSPCEEKVVKKQKQMQKEEDAEQVPDERSLAIA 1266
                  :::||.|:.|:...   |..|...|..|.|.|:..:
Frog   637 ------VQQDSYQDPVHQSFFMSALSVHPDRAHSHCWEQHCR----------------------- 672

  Fly  1267 RSFVKDYGPQFLPNYRLWQLNSAFKLDDVRTNPLHWTSWDVCEYIERALDSTDIAKVIFEQDIDG 1331
                      .||.......::..|          |::.:|..:::......|.|::..|:.|||
Frog   673 ----------LLPGVAGISASTVSK----------WSTEEVFSFVQTLTGCEDQARLFREEMIDG 717

  Fly  1332 RALLMLGRKELDTYLKLKVGPAVKLYSLIL 1361
            :|||:|.:.::...|.:|:|||||:|:.||
Frog   718 QALLLLTQTDIVKILCIKLGPAVKIYNSIL 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	48/98 (49%)
		MBT	929..1028	CDD:214723	41/103 (40%)
		MBT	1038..1130	CDD:214723	39/91 (43%)
		SAM_PNT	1279..1366	CDD:280377	24/83 (29%)
l3mbtl1	XP_031750143.1	MBT	231..326	CDD:214723	47/96 (49%)
		MBT	338..433	CDD:214723	41/102 (40%)
		MBT	446..537	CDD:214723	39/90 (43%)
		zf-C2HC	573..601	CDD:396216	10/32 (31%)
		SAM_Scm-like-3MBT3,4	685..750	CDD:188981	23/73 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7131
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002225
OrthoInspector	1	1.000	-	-		otm48574
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1471
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.000