DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfIIA-L and STON2

DIOPT Version :9

Sequence 1:	NP_476995.1	Gene:	TfIIA-L / 43284	FlyBaseID:	FBgn0011289	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_001353778.1	Gene:	STON2 / 85439	HGNCID:	30652	Length:	977	Species:	Homo sapiens

Alignment Length:	293	Identity:	65/293 - (22%)
Similarity:	92/293 - (31%)	Gaps:	71/293 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 PIKQEVNSQNP-----PPLHPTSAASMMQKQQQA---ASSGQGSIPIV----------------A 169
            |..|...||||     ....|...:|.:|:.::.   |.|.|.|.|.:                .
Human   226 PSPQPKRSQNPGEGPEGASAPNDNSSSLQEDEEVEMEAISWQASSPAMNGHPAPPVTSARFPSWV 290

  Fly   170 TLDPNRIM----PVNITL-----PSPA----------GSASSESRVLTIQVPASALQENQLTQIL 215
            |.|.|.:.    ||...|     ||.:          ||.....|      |.|.|......|.|
Human   291 TFDDNEVSCPLPPVTSPLKPNTPPSASVIPDVPYNSMGSFKKRDR------PKSTLMNFSKVQKL 349

  Fly   216 TAHLISSIMSLPTTLASS---VLQQHVNAAL-----SSANHQKTLAAAKQLDGALDSSDEDESEE 272
            .   |||:...|:...:|   .....:|..|     |..|........::......|......:.
Human   350 D---ISSLNRTPSVTEASPWRATNPFLNETLQDVQPSPINPFSAFFEEQERRSQNSSISSTTGKS 411

  Fly   273 SDDNIDNDDDDDLDKDDDEDAE-HEDAAEEEPLNSEDDVTDEDSAEMFDTDNVIVCQYD------ 330
            ..|::.....|.:..||....: |.||.|:......||.....||.:.|.|.|...:.|
Human   412 QRDSLIVIYQDAISFDDSSKTQSHSDAVEKLKQLQIDDPDHFGSATLPDDDPVAWIELDAHPPGS 476

  Fly   331 KITRSRNKWKFYL----KDGIMNMRGKDYVFQK 359
            ..::.|:.|...|    |..||:.|....:|.|
Human   477 ARSQPRDGWPMMLRIPEKKNIMSSRHWGPIFVK 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIA-L	NP_476995.1	TFIIA_alpha_beta_like	8..>62	CDD:199899
		TFIIA	11..366	CDD:281188	65/293 (22%)
		TFIIA_alpha_beta_like	<306..366	CDD:199899	17/64 (27%)
STON2	NP_001353778.1	Stonin2_N	1..397	CDD:314830	39/179 (22%)
STON2	NP_001353778.1	AP_stonin-2_MHD	616..928	CDD:271169
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1533
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030