DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TfIIA-L and GTF2A1

DIOPT Version :9

Sequence 1:	NP_476995.1	Gene:	TfIIA-L / 43284	FlyBaseID:	FBgn0011289	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_056943.1	Gene:	GTF2A1 / 2957	HGNCID:	4646	Length:	376	Species:	Homo sapiens

Alignment Length:	407	Identity:	144/407 - (35%)
Similarity:	210/407 - (51%)	Gaps:	86/407 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SVLKVYHAVIEDVITNVRDAFLDEGVDEQVLQEMKQVWRNKLLASKAVELSPDSGDGSH------ 65
            :|.|:|.:||||||.:|||.|||:|||||||.|:|.:|.|||:.|:||       ||.|
Human     9 TVPKLYRSVIEDVINDVRDIFLDDGVDEQVLMELKTLWENKLMQSRAV-------DGFHSEEQQL 66

  Fly    66 -------------------------PPPIVANNPKSHKAANAKAKKAAAATAVTSHQHIGGNSSM 105
                                     |...|....::.:.....:::|.|...:.....:..:.:.
Human    67 LLQVQQQHQPQQQQHHHHHHHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIVPDSKLIQHMNA 131

  Fly   106 SSLVGLKSSAGMAAGSGIRNGLVPIKQEVNSQNPPPLHPTSAAS----MMQKQQQAASSGQGSIP 166
            |::    |:|..||...:..|:.|: |::.:.:...|....||:    :.|.||......|
Human   132 SNM----SAAATAATLALPAGVTPV-QQILTNSGQLLQVVRAANGAQYIFQPQQSVVLQQQ---- 187

  Fly   167 IVATLDPNRIM-PV--NITLPSPAGSASSESRVLTIQVPASALQENQLTQILTAHLISSIMSLPT 228
            ::..:.|..:. ||  .:..|.| |..|.::.|: || |...|.....||:           :||
Human   188 VIPQMQPGGVQAPVIQQVLAPLP-GGISPQTGVI-IQ-PQQILFTGNKTQV-----------IPT 238

  Fly   229 TLASSVLQQHVNAALSSANHQKTLA--------AAKQLDGALD-SSDEDESEESDDNIDNDDDDD 284
            |:|:....|   |.:::...|:..|        ...|:||..| ||:|||.||.|  .|:|:::|
Human   239 TVAAPTPAQ---AQITATGQQQPQAQPAQTQAPLVLQVDGTGDTSSEEDEDEEED--YDDDEEED 298

  Fly   285 LDKDDDEDAEHEDAAEEEPLNSEDDVTDEDSAEMFDTDNVIVCQYDKITRSRNKWKFYLKDGIMN 349
            .:||..||.:    .|||||||||||:||:..|:|||:||:|||||||.||:|||||:|||||||
Human   299 KEKDGAEDGQ----VEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMN 359

  Fly   350 MRGKDYVFQKSNGDAEW 366
            :.|:||:|.|:.|||||
Human   360 LNGRDYIFSKAIGDAEW 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIA-L	NP_476995.1	TFIIA_alpha_beta_like	8..>62	CDD:199899	31/53 (58%)
		TFIIA	11..366	CDD:281188	140/401 (35%)
		TFIIA_alpha_beta_like	<306..366	CDD:199899	42/59 (71%)
GTF2A1	NP_056943.1	TFIIA	13..376	CDD:397322	140/401 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..107		2/37 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..266		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..329		32/60 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141873
Domainoid	1	1.000	144	1.000	Domainoid score	I4618
eggNOG	1	0.900	-	-		E1_KOG2652
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3786
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1443035at2759
OrthoFinder	1	1.000	-	-		FOG0002746
OrthoInspector	1	1.000	-	-		otm41527
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12694
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1533
SonicParanoid	1	1.000	-	-		X1433
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.980