DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TfIIA-L and unc-41

DIOPT Version :9

Sequence 1:	NP_476995.1	Gene:	TfIIA-L / 43284	FlyBaseID:	FBgn0011289	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_001256157.1	Gene:	unc-41 / 179387	WormBaseID:	WBGene00006777	Length:	1693	Species:	Caenorhabditis elegans

Alignment Length:	396	Identity:	73/396 - (18%)
Similarity:	129/396 - (32%)	Gaps:	122/396 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EDVITNV--RDAFLDEGVDEQV-----------LQEMKQVWRNKLLASKAVELSPDSGDGSHPPP 68
            |..:.||  ...|::|...:::           ||:.|...:.|..|:..:|  ||..|.
Worm   813 ESYLANVGGSQGFVNESTQKEIQRLTEEKKMEKLQKKKLKQQGKKAATPTLE--PDEEDA----- 870

  Fly    69 IVANNPKSHKAANAKAKKAAAATAVTSHQHIGGNSSMSSLVGLKSSAGMAAGSGIRNGLVPIKQ- 132
                   ..:||...|.|.|              |..|.:...|:..           ::|:|:
Worm   871 -------MDRAAQELAMKMA--------------SMRSDMADWKAPE-----------MIPVKEI 903

  Fly   133 -------EVNSQNPPPLHPTSAASMMQKQQQAASSGQGSIPIVATLDPNRIMPVNITLPSPAGSA 190
                   .|:|.:..|  |...:|:...||.:..|        ..|.|:...|.:...|:|.|..
Worm   904 KKAPEIRRVDSASAIP--PRKRSSIKDVQQDSGGS--------LELPPHLAAPQDSIAPNPKGDH 958

  Fly   191 SSESRVLTI-----------QVPAS-------------------ALQENQLTQILTAHLISSIMS 225
            :.:..:|:.           .:|.|                   |..:..:|.:.::...||.::
Worm   959 APDDPILSAPAWADFETSEPMLPPSESGFFSNKDASNEGGVSRDATDDPFVTTVASSEKRSSFVA 1023

  Fly   226 LPTTLASSVL--QQHVNAALSSANHQKTLAAAKQLDGALDSSDEDE-------------SEESDD 275
            .|.....:.|  :.:...|:.:......:|.||....|.::.:||:             :.|...
Worm  1024 DPFAPQQAALIDESYDPFAVVAVEEVVAMAKAKAEQAAANAENEDDFYNGRQSPTLSTPTPEGGS 1088

  Fly   276 NIDNDDDDDLDKDDDEDAEHEDAAEEEPLNSEDDVTD-EDSAEMFDTDNVIVCQYDKITRSRNKW 339
            .|.....:..: ||.:.||........||..|||... .|....||.|.     :|.:.|...|.
Worm  1089 PISQQRPNAFE-DDFKCAELTGLDTPTPLYDEDDSQPLTDFIPKFDGDG-----WDLMVRHPIKK 1147

  Fly   340 KFYLKD 345
            |.::.:
Worm  1148 KSFMAE 1153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIA-L	NP_476995.1	TFIIA_alpha_beta_like	8..>62	CDD:199899	13/57 (23%)
		TFIIA	11..366	CDD:281188	73/396 (18%)
		TFIIA_alpha_beta_like	<306..366	CDD:199899	11/41 (27%)
unc-41	NP_001256157.1	PH-like	1145..>1193	CDD:302622	2/9 (22%)
unc-41	NP_001256157.1	AP_MHD_Cterm	1279..1606	CDD:299401
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1533
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030