DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pll and RIPK2

DIOPT Version :9

Sequence 1:	NP_001263008.1	Gene:	pll / 43283	FlyBaseID:	FBgn0010441	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_003812.1	Gene:	RIPK2 / 8767	HGNCID:	10020	Length:	540	Species:	Homo sapiens

Alignment Length:	289	Identity:	84/289 - (29%)
Similarity:	128/289 - (44%)	Gaps:	30/289 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 LGQGGFGDVYRGK---WKQLDVAIKVMNYRSPNIDQKMVELQQSYNELKYLNSIRHDNILALYGY 280
            |.:|..|.|...:   |: :.||:|.::..:|.:|.   |.:....|.:.|:..|...||.:.|.
Human    24 LSRGASGTVSSARHADWR-VQVAVKHLHIHTPLLDS---ERKDVLREAEILHKARFSYILPILGI 84

  Fly   281 SIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHG 345
            ..:.....:|.:.|..|||...|  |: :...|.:.|..||.|....|.|:.:||... .||:|.
Human    85 CNEPEFLGIVTEYMPNGSLNELL--HR-KTEYPDVAWPLRFRILHEIALGVNYLHNMT-PPLLHH 145

  Fly   346 DIKPANILLDQCLQPKIGDFGLVREGPKSLDAVVEVNKV--FGTKIYLPPEFRNFR-----QLST 403
            |:|..|||||.....||.||||.:....||.........  .||.||:|||  |:.     :.|.
Human   146 DLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPE--NYEPGQKSRASI 208

  Fly   404 GVDVYSFGIVLLEVFTGRQVTDRVPENETKKNLLDYVKQQWRQNRMELLEKHLAAPMGKELDMCM 468
            ..|:||:.::..||.:.:|..:.|      .|.|..:....:.:|..:.|:.|...:.....| :
Human   209 KHDIYSYAVITWEVLSRKQPFEDV------TNPLQIMYSVSQGHRPVINEESLPYDIPHRARM-I 266

  Fly   469 CAIEAGLHCTALDPQDRPSMNAVLKRFEP 497
            ..||:|   .|.:|.:|||....|...||
Human   267 SLIESG---WAQNPDERPSFLKCLIELEP 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pll	NP_001263008.1	Death_Pelle	32..128	CDD:260021
		STKc_IRAK	219..498	CDD:270968	84/289 (29%)
		TyrKc	219..495	CDD:197581	82/285 (29%)
RIPK2	NP_003812.1	STKc_RIP2	20..303	CDD:270928	84/289 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..369
		CARD_RIP2_CARD3	438..524	CDD:176764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000