DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pll and RIPK1

DIOPT Version :9

Sequence 1:	NP_001263008.1	Gene:	pll / 43283	FlyBaseID:	FBgn0010441	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001341859.1	Gene:	RIPK1 / 8737	HGNCID:	10019	Length:	671	Species:	Homo sapiens

Alignment Length:	314	Identity:	89/314 - (28%)
Similarity:	136/314 - (43%)	Gaps:	64/314 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 LENATDGWSPDNRLGQGGFGDVYRGKWKQLDVAIKVMNYRSPN-IDQKMVELQQSYNELKYLNSI 269
            ||:|        .|..||||.|.....:...:.|....|:.|| |:.....|:    |.|.:|.:
Human    18 LESA--------ELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLE----EAKMMNRL 70

  Fly   270 RHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARGIYFL 334
            ||..::.|.|..|:.||..||.:.|:.|:|...|:| :...||..     :..|.|....|:.:|
Human    71 RHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKA-EMSTPLSV-----KGRIILEIIEGMCYL 129

  Fly   335 HTARGTPLIHGDIKPANILLDQCLQPKIGDFGL----------------VREGPKSLDAVVEVNK 383
            |   |..:||.|:||.|||:|.....||.|.||                :||    :|...:.|.
Human   130 H---GKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELRE----VDGTAKKNG 187

  Fly   384 VFGTKIYLPPEFRN--FRQLSTGVDVYSFGIVLLEVFTGRQVTDRVP-ENE-TKKNLLDYVKQQW 444
              ||..|:.||..|  ..:.:...|||||.:||..:|..::     | ||. .::.|:..:|...
Human   188 --GTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKE-----PYENAICEQQLIMCIKSGN 245

  Fly   445 RQNRMELLEKHLAAPMGKELDMCMCAIEAGLHCTALDPQDRPSMNAVLKRFEPF 498
            |.:..::.|   ..|  :|:...|..      |...:|:.||:...:.::|.||
Human   246 RPDVDDITE---YCP--REIISLMKL------CWEANPEARPTFPGIEEKFRPF 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pll	NP_001263008.1	Death_Pelle	32..128	CDD:260021
		STKc_IRAK	219..498	CDD:270968	84/299 (28%)
		TyrKc	219..495	CDD:197581	83/296 (28%)
RIPK1	NP_001341859.1	STKc_RIP1	23..290	CDD:270929	86/301 (29%)
		Interaction with SQSTM1. /evidence=ECO:0000269\|PubMed:10356400	290..582
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..354
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..458
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:11734559, ECO:0000269\|PubMed:29681455	531..547
		Death_RIP1	583..668	CDD:260048
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000