DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pll and IOS1

DIOPT Version :9

Sequence 1:	NP_001263008.1	Gene:	pll / 43283	FlyBaseID:	FBgn0010441	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_175591.1	Gene:	IOS1 / 841606	AraportID:	AT1G51800	Length:	894	Species:	Arabidopsis thaliana

Alignment Length:	448	Identity:	115/448 - (25%)
Similarity:	189/448 - (42%)	Gaps:	67/448 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 SNEFLNIWGGQYNHTVQTLFALFKKLKLHNAMRLIKDYVSEDLHKYIPRSVPTISELRAAPDSSA 147
            |.|.|::.......:|....|..:.|||.|..       ..:|:..||.:: ...|.|.:...|.
plant   433 SLEVLDLSNNSLTGSVPEFLANMETLKLINLS-------GNELNGSIPATL-LDKERRGSITLSI 489

  Fly   148 KVNNGPPFPSSSGVSNSNNNRTSTTATEEIPSLESL-----GNIHISTVQRAAESLLEIDYAELE 207
            :.|.|  ..||:..:.:...:.:|.......||.|:     |.:....::|...:.|.::    .
plant   490 EGNTG--LCSSTSCATTKKKKKNTVIAPVAASLVSVFLIGAGIVTFLILKRKKRTKLGLN----P 548

  Fly   208 NATDGWSP---------------DNR-----------------LGQGGFGDVYRGKWKQLDVAIK 240
            |:..|.:|               .||                 ||:||||.||.|......||:|
plant   549 NSGTGTTPLHSRSHHGFEPPVIAKNRKLTYIDVVKITNNFERVLGRGGFGVVYYGVLNNEPVAVK 613

  Fly   241 VMNYRSPNIDQKMVELQQSYNELKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRA 305
            ::.      :...:..:|...|::.|..:.|.::..|.||..:|.|..|:|:.|..|.|:..|..
plant   614 MLT------ESTALGYKQFKAEVELLLRVHHKDLTCLVGYCEEGDKMSLIYEFMANGDLKEHLSG 672

  Fly   306 HKAQNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVRE 370
            .:..:   .|||:.|..|:..:|:|:.:||......::|.|||..||||::..|.|:.||||.|.
plant   673 KRGPS---ILTWEGRLRIAAESAQGLEYLHNGCKPQIVHRDIKTTNILLNEKFQAKLADFGLSRS 734

  Fly   371 GPKSLDAVVEVNKVFGTKIYLPPEFRNFRQLSTGVDVYSFGIVLLEVFTGRQVTDRVPENETKKN 435
            .|...:..|. ..|.||..||.||:.....|:...||:|||:||||:.|.:.|.|...|   |.:
plant   735 FPLGTETHVS-TIVAGTPGYLDPEYYRTNWLTEKSDVFSFGVVLLELVTNQPVIDMKRE---KSH 795

  Fly   436 LLDYVKQQW-RQNRMELLEKHLAAPMGKELDMCMCAIEAGLHCTALDPQDRPSMNAVL 492
            :.::|.... |.:...:::..|....  :.:.....:|..:.|.......||:|..|:
plant   796 IAEWVGLMLSRGDINSIVDPKLQGDF--DPNTIWKVVETAMTCLNPSSSRRPTMTQVV 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pll	NP_001263008.1	Death_Pelle	32..128	CDD:260021	10/44 (23%)
		STKc_IRAK	219..498	CDD:270968	84/275 (31%)
		TyrKc	219..495	CDD:197581	84/275 (31%)
IOS1	NP_175591.1	Malectin_like	32..352	CDD:315486
		PLN00113	<409..>498	CDD:331614	17/74 (23%)
		leucine-rich repeat	412..433	CDD:275380	115/448 (26%)
		leucine-rich repeat	434..457	CDD:275380	4/22 (18%)
		STKc_IRAK	592..856	CDD:270968	84/275 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.870